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Dinneswara Reddy, Guda,Park, Sae-Jin,Cho, Hyeon Mo,Kim, Tack-Joong,Lee, Myong Euy American Chemical Society 2012 Journal of medicinal chemistry Vol.55 No.14
<P>A new class of sila-substituted 1,3,4-oxadiazoles was synthesized and evaluated for antiallergic activity using RBL-2H3 as the in vitro model and the in vivo anaphylactic mouse model. We observed that compound 5c effectively suppressed DNP-HSA-induced mast cell degranulation, compared to carbon analogue 9, and also suppressed the expression of TNF-α mRNA and Akt phosphorylation in antigen-stimulated RBL-2H3 cells. We also studied the effect of 5c in an in vivo passive cutaneous anaphylaxis (PCA) mouse model. The suppression by 5c was more effective than that by diphenylhydramine (DPH), a typical anti-histamine drug.</P>
Thanh Nguyen Huu,Shaariikhuu Erdenechimeg,Nguyen Thi Xuyen,Hossain Muhammad Sarwar,Tae Eunju Lee,Reddy Guda Dinneswara,윤경병 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.4
Cross-linked polystyrene and polydivinylbenzene (PDVB) have unreacted pendant vinyl groups. They readily undergo aging or oxidation with air even at room temperature, giving rise to formation of OH and (CO)CH3 groups within the polymers. We now report that the aging process involves the release of carbon monoxide (CO) and hydrogen (H2) in significant amounts at 40 C and the rate increases with time and temperature. The amounts of CO and H2 released from PDVB at a given temperature can be expressed using a polyno- mial equation of Aa = Bt + Ct2, where Aa is the accumulated amount, t is the time in the unit of day, and B and C are the coefficients. The coefficients B and D increase with increasing temperature. This result shows that the storage rooms for the above polymers and their composites should be well ventilated to prevent inhalation of CO by the workers and H2-induced potential hazards.