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RISS 인기검색어
- 검색키워드
- 저자 : Ratan Singh (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Singh, Ratan,Kumar, Raj,Singh, D.P. The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
The nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs in the world. Their use as anti-inflammatory, antipyretic, antithrombotic, and analgesic agents is, however, restricted by their adverse effects on gastrointestinal (GI) tract. To overcome this problem with NSAIDs, two new strategies in the development of these drugs are explained. The first approach is the development of selective inhibitors of the enzyme cyclooxygenase (COX)-2, the inducible isoform of the prostaglandin G/H synthetase enzyme. COX exists in two isoforms, viz., COX-1 and COX-2. Selective inhibitors of COX-2 will suppress prostaglandin synthesis at the sites of inflammation, but they will not interfere with the activity of COX-1, in tissues like the GI tract. The use of selective COX-2 inhibitors, however, lacks the cardioprotective effects mediated by COX-1. An alternate approach to reduce the GI toxicity of NSAIDs is the development of nitric oxide (NO)-releasing NSAIDs. It has been reported that NO does not affect the gastroduodenal mucosa and produces the same effects as endogenous prostaglandins. The present article focuses on the NO-releasing NSAIDs, which are from the conventional class of COX-2 inhibitors that have potential clinical applications, as well as some drug candidates still under development.
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Ratan Singh,Raj Kumar,D.P. Singh 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.1
The nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs in the world. Their use as anti-inflammatory, antipyretic, antithrombotic, and analgesic agents is, however, restricted by their adverse effects on gastrointestinal (GI) tract. To overcome this problem with NSAIDs, two new strategies in the development of these drugs are explained. The first approach is the development of selective inhibitors of the enzyme cyclooxygenase (COX)-2, the inducible isoform of the prostaglandin G/H synthetase enzyme. COX exists in two isoforms, viz., COX-1 and COX-2. Selective inhibitors of COX-2 will suppress prostaglandin synthesis at the sites of inflammation, but they will not interfere with the activity of COX-1, in tissues like the GI tract. The use of selective COX-2 inhibitors, however, lacks the cardioprotective effects mediated by COX-1. An alternate approach to reduce the GI toxicity of NSAIDs is the development of nitric oxide (NO)-releasing NSAIDs. It has been reported that NO does not affect the gastroduodenal mucosa and produces the same effects as endogenous prostaglandins. The present article focuses on the NO-releasing NSAIDs, which are from the conventional class of COX-2 inhibitors that have potential clinical applications, as well as some drug candidates still under development.
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Temperature-dependent rheological behaviour of methylcellulose nanocomposite organogels
Ratan Pal Singh 한국고분자학회 2023 Macromolecular Research Vol.31 No.1
The temperature-dependent gelation phenomenon of methylcellulose (MC) in the organic solvent N, N-Dimethyl formamide (DMF) is examined for various surfactants using dynamic mechanical analysis under compression technique. The peaks got in the dynamic strain experiment may represent the fluidity in the structure above 60 ℃. Upon further heating, there is an increase in the enthalpy, which involves the arbitrary vibration of free –OCH3 functional groups of MC, resulting in non-polar interactions to build a complex viscous liquid. A vast increment in dynamic strain value manifests the solubility of MC in DMF. During the Scanning electron microscopy (SEM) investigations of dry MC films, the entangled globules-rod conformations are seen. These conformations are capable of absorbing a large amount of energy before the rapture. The spring-like structure of these conformations encourages the MC-DMF gel regime to absorb energy and distribute it among the non-conformational sol–gel area. High storage modulus value signifies a higher crosslink density and a tendency to absorb more vibrational-thermal energy without disintegrating. We investigated the stability of these gels through computational studies, where the potential energy between a single surfactant molecule and the dimeric form of MC is calculated.
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