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      저자 : Rasool Dezhkam (검색결과 1 건)
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        Numerical investigation of centrifugal passive cell separation in three types of serpentine microchannels and comparison with fixed platform

        Rasool Dezhkam,Ali Shafiei Souderjani,Amir Shamloo,Mohammadmahdi Eskandarisani,Ali Mashhadian 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-

        Cell separation plays a crucial role in diagnosing and improving a wide range of diseases, such as cancer,which is a severe reason for the death of people in the current decades. Circulating tumor cells (CTCs)inside the blood can be separated from the other whole blood cells to detect early cancer. Inertial methodsare more superficial and cost less than the current CTC separation methods. These methods also havegreat potential in high-throughput separation in lab-on-a-chip (LOC) and lab-on-a-disk (LOD) devicesbecause of secondary flow generation, especially in serpentine-shaped microchannels. The present studyconsiders a continuous process for separating CTCs from the blood sample. This process is utilized in LODdevices, and this platform is also compared with the LOC platform. Moreover, two common types of differentserpentine-shaped channels (simple and curved) and a new Omega channel are compared. Itshould be noted that a direct numerical simulation (DNS) method is used for calculating lift force inthe serpentine-shaped channels. The effect of fluid velocity on WBC and CTC separation efficiency inthe three mentioned different geometries are investigated in both fixed and rotational platforms, thenthe best results for each of them are presented. Finally, the best results belonged to the simple serpentinebetween the three investigated channels, with a separation percentage of 100. Moreover, in comparingthe two mentioned platforms, LOD showed a more efficient application in cell separation. In addition,the Omega channel is investigated as a novel serpentine geometry. According to the results, it can be usedfor particle focusing applications thanks to its 100 percent efficiency at 0.5 m/s in both LOD and LOCplatforms.

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