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RISS 인기검색어
- 검색키워드
- 저자 : Ramesh L Londonkar (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Londonkar, Ramesh,Kamble, Abhaykumar 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
The present study was carried out to evaluate the antioxidant effect of methanol extract of $Pandanus$ $odoratissimus$ lim (MEPO) leaf in wistar albino rats. The animals were grouped differently and administered with Carbon tetrachloride ($CCl_4$) (1.5/$kg^{-1}$ $CCl_4$ 1 ml $kg^{-1}$ in liquid paraffin 3 doses (i.p) at 72 h interval). The extracts at the doses of 50 and 100 mg $kg^{-1}$ and Liv 52 25 mg $kg^{-1}$ were administered to the $CCl_4$ treated rats. The effect of extract and Liv 52 on serum transaminase (GOT, GPT), alkaline phosphatease (ALP), bilirubin and total protein were measured in the rat induced by $CCl_4$. The effect of extract on lipid peroxidation (LPO), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and Vitamin E were estimated. The extract and Liv 52 produced significant ($P$ <0.05) effect by decreasing the activity of serum enzymes, bilirubin, uric acid and lipid peroxidation and significantly ($P$ <0.05) increased in the level of SOD, CAT, GSH, Vitamin E and protein. Hence these results suggest that Methanolic extract of Pandanus odoratissimus has potent antioxidant properties.
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Ramesh Londonkar,Abhaykumar Kamble 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
The present study was carried out to evaluate the antioxidant effect of methanol extract of Pandanus odoratissimus lim (MEPO) leaf in wistar albino rats. The animals were grouped differently and administered with Carbon tetrachloride (CCl_4) (1.5/kg^(−1) CCl_4 1 ml kg^(−1) in liquid paraffin 3 doses (i.p) at 72 h interval). The extracts at the doses of 50 and 100 mgkg^(−1) and Liv 52 25 mg kg^(−1) were administered to the CCl_4 treated rats. The effect of extract and Liv 52 on serum transaminase (GOT, GPT), alkaline phosphatease (ALP), bilirubin and total protein were measured in the rat induced by CCl_4. The effect of extract on lipid peroxidation (LPO), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and Vitamin E were estimated. The extract and Liv 52 produced significant (P<0.05) effect by decreasing the activity of serum enzymes, bilirubin, uric acid and lipid peroxidation and significantly (P<0.05)increased in the level of SOD, CAT, GSH, Vitamin E and protein. Hence these results suggest that Methanolic extract of Pandanus odoratissimus has potent antioxidant properties.
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Morphine induced inhibition of the activities of accessory reproductive ducts in male rats
Londonkar, Ramesh L.,Sharangouda, Sharangouda,Patil, Saraswati B. Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.1
Adult male albino rats were treated with 0.5 mg and 0.75 mg morphine/100 g body weight intraperitoneally for 30 days. All the animals were autopsied on $31^{st}$ day. Epididymis and vas deferens were dissected out, weighed and processed for histological and biochemical studies. Morphine has caused a reduction in the weight of epididymis and vas deferens in both the doses of drug treated groups. The total cholesterol content is increased while protein, DNA and RNA contents and epididymal sperm counts are decreased. The acid phosphatase content is decreased 10.12 $\pm$ 0.11 in caput, 9.26 $\pm$ 0.30 in cauda of epididymis and in vas deferens 8.14 $\pm$ 0.15 in 0.5 mg treated groups and in 0.75 mg treated rats shows 9.52 $\pm$ 0.27 in caput, 9.14 $\pm$ 0.18 in cauda of epididymis and in vas deferens 7.84 $\pm$ 0.11is decreased, whereas alkaline phosphatase is increased. The surface epithelial cell height of these ducts is reduced and secretory activity is inhibited with the disruption of epithelial cell projections. The gravimetric and histometric changes of epididymis and vas deferens may be due to non-availability of androgens in morphine treated rats.
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Morphine induced inhibition of the activities of accessory reproductive ductsin male rats
Ramesh L Londonkar,Sharangouda,Saraswati B Patil 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.1
Adult male albino rats were treated with 0.5 mg and 0.75 mg morphine/100 g body weight intraperitoneally for 30 days. All the animals were autopsied on 31st day. Epididymis and vas deferens were dissected out, weighed and processed for histological and biochemical studies. Morphine has caused a reduction in the weight of epididymis and vas deferens in both the doses of drug treated groups. The total cholesterol content is increased while protein, DNA and RNA contents and epididymal sperm counts are decreased. The acid phosphatase content is decreased 10.12 ± 0.11 in caput, 9.26 ± 0.30 in cauda of epididymis and in vas deferens 8.14 ± 0.15 in 0.5 mg treated groups and in 0.75 mg treated rats shows 9.52 ± 0.27 in caput, 9.14 ± 0.18 in cauda of epididymis and in vas deferens 7.84 ± 0.11is decreased, whereas alkaline phosphatase is increased. The surface epithelial cell height of these ducts is reduced and secretory activity is inhibited with the disruption of epithelial cell projections. The gravimetric and histometric changes of epididymis and vas deferens may be due to non-availability of androgens in morphine treated rats. Adult male albino rats were treated with 0.5 mg and 0.75 mg morphine/100 g body weight intraperitoneally for 30 days. All the animals were autopsied on 31st day. Epididymis and vas deferens were dissected out, weighed and processed for histological and biochemical studies. Morphine has caused a reduction in the weight of epididymis and vas deferens in both the doses of drug treated groups. The total cholesterol content is increased while protein, DNA and RNA contents and epididymal sperm counts are decreased. The acid phosphatase content is decreased 10.12 ± 0.11 in caput, 9.26 ± 0.30 in cauda of epididymis and in vas deferens 8.14 ± 0.15 in 0.5 mg treated groups and in 0.75 mg treated rats shows 9.52 ± 0.27 in caput, 9.14 ± 0.18 in cauda of epididymis and in vas deferens 7.84 ± 0.11is decreased, whereas alkaline phosphatase is increased. The surface epithelial cell height of these ducts is reduced and secretory activity is inhibited with the disruption of epithelial cell projections. The gravimetric and histometric changes of epididymis and vas deferens may be due to non-availability of androgens in morphine treated rats.
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