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WPAN Based Cattle Health Monitoring With Labview as A Data Logger
Ateev Agarwal,Eesh Mehandiratta,Rohit Sanket,Rohit Samkaria,Ambujaksh Shah,Rajesh Singh,Anita Gehlot 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.6
A wireless cattle health monitoring system to measure health and psychological parameter of cattle has been developed using environmental temperature and humidity, body temperature, rumination, heartbeat, and sweat sensors. The system developed is capable to analyze stress level of cattle’s with reference to THI (Thermal Humidity Index). System is developed according to IEEE1451.1, 1451.2, and 802.15.4 standards. The ATmega16 controller and zigbee has been used to develop the wireless sensor and receiver nodes. LabVIEW is used as a real time data logger for monitoring the output of various sensors over the PC. This real time data monitoring is much inexpensive technique for monitoring of health of livestock. Power consumption of the device has been kept minimum. The device is successfully designed, made, and tested.
Smart Door Lock System for Elderly, Handicapped People Living Alone
Ateev Agarwal,Eesh Mehandiratta,Rohit Sanket,Rohit Samkaria,Tanisha Gupta,Rajesh Singh,Anita Gehlot 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.6
The old, deaf and blind people faces problem in opening and closing of the door in their house as they have to walk to the door to do so. This paper is about the device which is made to solve the problem faced by old people of opening and closing of door again and again, by using an Arduino based remote that can control the door lock using RF module, for receiving and transmitting the data. The product consists of two devices both are based on Arduino. One of the two devices will be fitted at the door that will send the signals to indicate the old person to open the device and will receive the signal to open and close the door lock while the other device will work as a remote consists of chargeable batteries, easy to carry just like a mobile will help to indicate the person carrying it to open the door. The receiving and transferring of signals will be done using RF modules connected to the Arduino boards. The device will help to ease the problem faced by the old, blind and deaf people in controlling the door lock from any part of the house. In future, the RF module in the device to transmit and receive the data can be replaced by Internet of things technology to control the lock from any part of the world. More features like controlling of home appliances, windows etc. will also be the part of this device in future therefore, it has a good future scope also.
Exploring the Potential of Natural Products as FoxO1 Inhibitors: an In Silico Approach
Gupta Anugya,Haldhar Rajesh,Agarwal Vipul,Rajput Dharmendra Singh,Chun Kyung-Soo,Han Sang Beom,Raj Vinit,Lee Sangkil 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.3
FoxO1, a member of the Forkhead transcription factor family subgroup O (FoxO), is expressed in a range of cell types and is crucial for various pathophysiological processes, such as apoptosis and inflammation. While FoxO1’s roles in multiple diseases have been recognized, the target has remained largely unexplored due to the absence of cost-effective and efficient inhibitors. Therefore, there is a need for natural FoxO1 inhibitors with minimal adverse effects. In this study, docking, MMGBSA, and ADMET analyses were performed to identify natural compounds that exhibit strong binding affinity to FoxO1. The top candidates were then subjected to molecular dynamics (MD) simulations. A natural product library was screened for interaction with FoxO1 (PDB ID- 3CO6) using the Glide module of the Schrödinger suite. In silico ADMET profiling was conducted using SwissADME and pkCSM web servers. Binding free energies of the selected compounds were assessed with the Prime-MMGBSA module, while the dynamics of the top hits were analyzed using the Desmond module of the Schrödinger suite. Several natural products demonstrated high docking scores with FoxO1, indicating their potential as FoxO1 inhibitors. Specifically, the docking scores of neochlorogenic acid and fraxin were both below -6.0. These compounds also exhibit favorable drug-like properties, and a 25 ns MD study revealed a stable interaction between fraxin and FoxO1. Our findings highlight the potential of various natural products, particularly fraxin, as effective FoxO1 inhibitors with strong binding affinity, dynamic stability, and suitable ADMET profiles.
Kushal Kandhari,Sandeep Paudel,Komal Raina,Chapla Agarwal,Rama Kant,Michael F. Wempe,Cindy O’Bryant,Rajesh Agarwal 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.4
Given the high rates of incidence and mortality associated with pancreatic cancer (PanC), there is a need to develop alternative strategies to target PanC. Recent studies have demonstrated that fruits of bitter melon (Momordica charantia) exhibit strong anticancer efficacy against PanC. However, the comparative effects of different bitter melon varieties have not been investigated. This has important implications, given that several bitter melon cultivars are geographically available but their differential effects are not known; and that on a global level, individuals could consume different bitter melon varieties sourced from different cultivars for anti-PanC benefits. Considering these shortcomings, in the present study, comparative pre-clinical anti-PanC studies have been conducted using lyophilized-juice and aqueous-methanolic extracts of the two most widely consumed but geographically diverse bitter melon varieties (Chinese [bitter melon juice; BMJ] and Indian [bitter melon extract; BME] variants). We observed that both BMJ and BME possess comparable efficacy against PanC growth and progression; specifically, these preparations have the potential to (a) inhibit PanC cell proliferation and induce cell death; (b) suppress PanC tumor growth, proliferation, and induce apoptosis; (c) restrict capillary tube formation by human umbilical vein endothelial cells, and decrease angiogenesis in PanC tumor xenografts. Thus, given the comparable pre-clinical anti-PanC efficacy of bitter melon cultivars, the geographical non-availability of a certain cultivar should not be a limiting factor in selecting a variant for moving forward for future clinical use/clinical trials either as a preventive or a therapeutic alternative for targeting PanC. Key Words Pancreatic neoplasms, Bitter melon, Apoptosis, Angiogenesis, Natural/dietary agents
Subash Gupta,Rajasekhar Kandagaddala,Shaleen Agarwal,Rajesh Dey,Selvakumar Naganathan,Peeyush Varshney,Nilesh Patil 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.4
Backgrounds/Aims: In living donor hepatectomy, hepatic duct division is a crucial step and often a technical challenge, with the aim of obtaining a good hepatic duct for anastomosis in the recipient and an adequate stump in the donor for closure. Very rarely, after duct division, the remaining stump may not be adequate for primary closure. In such a difficult situation, the options would be either to close stump transversely or a Roux-en-Y Hepaticojejunostomy. Methods: We describe a novel surgical technique of “Cystic duct patch repair”, utilizing the available local tissues for closure of bile duct wall. Results: Two year follow up of this technique showed satisfactory results with no evidence of stricture and normal liver functions. Conclusions: In living donor hepatectomy, “Cystic duct patch closure” may be used if the post closure cholangiogram is not satisfactory. Although the best method is prevention by ensuring a stump for closure, very rarely this error can occur and can be sorted by cystic duct patch repair.
Aarathi Vijayashanker,Bhargava Ram Chikkala,Roshan Ghimire,Ravindra Nidoni,Yuktansh Pandey,Rajesh Dey,Shaleen Agarwal,Subhash Gupta 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.3
Backgrounds/Aims: Multiple ducts in right lobe living-donor liver transplant (LDLT) pose a technical challenge in biliary reconstruction. In the absence of separate recipient hepatic ducts for duct-to-duct anastomoses and certain demerits of hepaticojejunostomy, duct to duct anastomoses with the recipient cystic duct might be a possible solution. Methods: A total of 329 recipients of LDLT who underwent two or more separate biliary anastomoses at our centre between January 2014 and November 2019 were studied retrospectively. Records of demographic data, donor and graft characteristics, operative details, postoperative biochemical parameters, and biliary complications were analysed. Results: Of 329 recipients, 236 patients (71.7%) underwent purely duct-to-duct (DD group) anastomoses, 38 patients (11.5%) underwent at least one anastomosis with the cystic duct (CD group), and 55 patients (16.7%) underwent at least one hepaticojejunostomy (HJ group). At one year, biliary complication rates of these three groups were 20.3%, 26.3%, and 20.0%, respectively (p = 0.68). Postoperative intensive care unit and overall hospital stay were similar among the three groups. Grades IIIa, IIIb, IV, and V Clavien-Dindo complications were identical. One-year patient survival and graft survival were also similar among the three groups. Conclusions: Biliary outcomes using the cystic duct may have acceptable outcomes. Similar postoperative results as other means of biliary reconstruction could be anticipated with the cystic duct anastomoses in case of multiple ducts in the graft.