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Colonic Postpolypectomy Bleeding Is Related to Polyp Size and Heparin Use
Flavia Pigò,Helga Bertani,Mauro Manno,Vincenzo Giorgio Mirante,Angelo Caruso,Santi Mangiafico,Raffaele Manta,Anna Maria Rebecchi,Rita Luisa Conigliaro 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.3
Background/Aims: We studied factors influencing colon postpolypectomy bleeding (PPB), with a focus on antithrombotic and anticoagulation therapy. Methods: We conducted a retrospective case-control study of all patients who underwent polypectomy at our tertiary referral center in Italy between 2007 and 2014. Polyp characteristics (number of polyps removed per patient, size, morphology, location, resection technique, prophylactic hemostasis methods) and patient characteristics (age, sex, comorbidities, medication) were analyzed. Results: The case and control groups included 118 and 539 patients, respectively. The two groups differed in the frequency of comorbidities (69% vs. 40%, p=0.001), polyps removed (27% vs. 18%, p=0.02), and use of heparin therapy (23% vs. 1%, p<0.001). A total of 279 polyps in the case group and 966 in the control group were nonpedunculated (69% vs. 81%, p=0.01) and measured ≥10 mm (78% vs. 32%, p=0.001). Multivariate analysis showed that polyps ≥10 mm (odds ratio [OR], 6.1; 95% confidence interval [CI], 2.3–15.5), administration of heparin (OR, 16.5; 95% CI, 6.2–44), comorbidity (OR, 2.3; 95% CI, 1.4–3.9), and presence of ≥2 risk factors (OR, 3.2; 95% CI, 1.7–6.0) were associated with PPB. Conclusions: The incidence of PPB increases with polyp size ≥10 mm, heparin use, comorbidity, and presence of ≥2 risk factors.
Endoscopic clipping in non-variceal upper gastrointestinal bleeding treatment
Giuseppe Galloro,Angelo Zullo,Gaetano Luglio,Alessia Chini,Donato Alessandro Telesca,Rosa Maione,Matteo Pollastro,Giovanni Domenico De Palma,Raffaele Manta 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.3
Since the earliest reports, advanced clipping systems have been developed, and it is possible to choose among many models with differentstructural and technical features. The main drawback of through-the-scope clips is their small size, which allows the compressionof limited amounts of tissue needed for large-size vessel treatment. Therefore, the over-the-scope clip system was realized, allowing alarger and stronger mechanical compression of large tissue areas, with excellent results in achieving a definitive hemostasis in difficultcases. Many studies have analyzed the indications and efficacy of two-pronged endoclips and have shown good results for initial andpermanent hemostasis. The aim of this review was to provide updated information on indications, positioning techniques, and resultsof clip application for endoscopic treatment of upper gastrointestinal non-variceal bleeding lesions.