http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Phytochemical Analysis and Antinociceptive Properties of the Seeds of Garcinia achachairu
Marlova Manhabosco Dal Molin,Rivaldo Niero,Suellen Silva,Douglas Rafael Alves,Nara Lins Meira Quintão,Franco Delle Monache,Valdir Cechinel Filho 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.4
In a search for new and effective analgesic substances from the Brazilian biodiversity, the present study evaluates the chemical composition and antinociceptive potential of the methanol extract and a pure compound obtained from the seeds of Garcinia achachairu Rusby (Clusiaceae). The methanolic seed extract was directly subjected to purification by column chromatography and the purification was monitored by thin-layer chromatography. The main isolated compound was identified as Guttiferone A by comparison of conventional spectroscopic data (IR, NMR-1H and 13C) to the literature data which was isolated for the first time from this plant. When evaluated in the acetic acid-induced nociception model in mice, the methanolic seed extract had an ID50 (Inhibitory dose) of 13.1 (11.23-14.91) mg/kg and a maximal inhibition of 72 ± 4%. In the same model, Guttiferone A had an ID50 of 4.54 (3.29-6.24) mg/kg and a maximal inhibition of 73 ± 5%. The methanolic seed extract and Guttiferone A were also active in pain models induced by formalin, capsaicin, glutamate and carrageenan. These data suggest that the antinociceptive effect of Guttiferone A partly depends on its interference with the synthesis or activity of the cytokine TNF-α, the keratinocyte-derived chemokine KC, and/or PGE2. These data support, at least in part, the use of G. achachairu in folk medicine and suggest that this plant is an important source of compounds with a suitable profile for development as new and effective medicinal agents to treat pain processes.
Type-specific human papillomavirus distribution in invasive cervical cancer in Korea, 1958-2004.
Oh, Jin-Kyoung,Alemany, Laia,Suh, Jung-Il,Rha, Seo-Hee,Muñ,oz, Nubia,Bosch, F Xavier,Quint, Wim,Lloveras, Belen,Klaustermeier, Jo Ellen,de Sanjosé,, Silvia,Shin, Hai-Rim Asian Pacific Organization for Cancer Prevention 2010 Asian Pacific journal of cancer prevention Vol.11 No.4
<P>To describe the HPV genotype distribution and to investigate the underlying secular trend in the relative contribution of HPV types 16-18 in invasive cervical cancer (ICC) over a period of 47 years (1958-2004) in South Korea.</P>
Reed, M. D.,Harms, S. L.,Poindexter, S.,Zhou, A.‐,Y.,Eggen, J. R.,Morris, M. A.,Quint, A. C.,McDaniel, S.,Baran, A.,Dolez, N.,Kawaler, S. D.,Kurtz, D. W.,Moskalik, P.,Riddle, R.,Zola, S.,Østense Blackwell Publishing Ltd 2011 Monthly notices of the Royal Astronomical Society Vol.412 No.1
<P><B>ABSTRACT</B></P><P>KPD 1930+2752 is a short‐period pulsating subdwarf B (sdB) star. It is also an ellipsoidal variable with a known binary period of 2.3 h. The companion is most likely a white dwarf and the total mass of the system is close to the Chandresekhar limit. In this paper, we report the results of Whole Earth Telescope (WET) photometric observations during 2003 and a smaller multisite campaign of 2002. From 355 h of WET data, we detect 68 pulsation frequencies and suggest an additional 13 frequencies within a crowded and complex temporal spectrum between 3065 and 6343 μHz (periods between 326 and 157 s). We examine pulsation properties including phase and amplitude stability in an attempt to understand the nature of the pulsation mechanism. We examine a stochastic mechanism by comparing amplitude variations with simulated stochastic data. We also use the binary nature of KPD 1930+2752 for identifying pulsation modes via multiplet structure and a tidally induced pulsation geometry. Our results indicate a complicated pulsation structure that includes short‐period (≈16 h) amplitude variability, rotationally split modes, tidally induced modes and some pulsations which are geometrically limited on the sdB star.</P>