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Pyoderma Gangrenosum in a Patient with X-Linked Agammaglobulinemia
( Qi Tan Fa-liang Ren ),( Hua Wang ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.4
X-linked agammaglobulinemia (XLA) is a primary im-munodeficiency disorder caused by germline mutations of B-cell tyrosine kinase (BTK) gene. It is characterized by de-creased serum immunoglobulins levels and circulating ma-ture B cells. This defect in humoral immunity leads to in-creased susceptibility to infection. Pyoderma gangrenosum (PG) is an uncommon, ulcerating, neutrophilic dermatosis. Here we report PG in an 8-year-old patient with XLA. The pa-tient received intravenous immunoglobulin treatment in conjunction with prednisone and topical application of 0.03% tacrolimus ointment and the ulcer was almost com-pletely healed in the 2 weeks of follow-up. The coexistence has been rarely reported. XLA may be a possible cofactor in the pathogenesis of PG. (Ann Dermatol 29(4) 476∼478, 2017)
( Zhen Fa Qi ) 한국세무회계학회 2007 발표논문집 Vol.21 No.-
In the age of knowledge economy, human society is undergoing a great revolution from industry economy to knowledge economy, and human resources management has becomean important part of operational strategy of enterprises. Human resources possessing knowledge are the first important resources. The paper has put forward that human resources now available are the major force and the practical choice of sustainable development of enterprises. Based on the analysis of the current talents resources in enterprises and the characteristic of talents in enterprises under the conditions of knowledge economy, the paper has also come up with countermeasures that enterprises keeps and make good use of talents, namely, to develop pay-for-performance policies, to intensify efforts to inspire talents, to create conditions to keep talents by causes and to set up cause platform for talents, to accelerate the renewal of knowledge of the existing talents, strengthen talents` exercise and cultivation in practices, to retain talents by emotion, and to adopt open policies of talents, set up the new mechanism of talents management. The study is conducive to guide enterprises to retain, foster, make good use of talents resources, and also is favorable to realize sustainable development of enterprises.
Ye, Qi-Fa,Zhang, Yi-Chuan,Peng, Xiao-Qing,Long, Zhi,Ming, Ying-Zi,He, Le-Ye Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Purpose: Notch is an important signaling pathway that regulates cell fate, stem cell maintenance and the initiation of differentiation in many tissues. It has been reported that activation of Notch-1 contributes to tumorigenesis. However, whether Notch signaling might have a role in chemoresistance of prostate cancer is unclear. This study aimed to investigate the effects of Notch-1 silencing on the sensitivity of prostate cancer cells to docetaxel treatment. Methods: siRNA against Notch-1 was transfected into PC-3 prostate cancer cells. Proliferation, apoptosis and cell cycle distribution were examined in the presence or absence of docetaxel by MTT and flow cytometry. Expression of $p21^{waf1/cip1}$ and Akt as well as activation of Akt in PC-3 cells were detected by Western blot and Real-time PCR. Results: Silencing of Notch-1 promoted docetaxel induced cell growth inhibition, apoptosis and cell cycle arrest in PC-3 cells. In addition, these effects were associated with increased $p21^{waf1/cip1}$ expression and decreased Akt expression and activation in PC-3 cells. Conclusion: Notch-1 promotes chemoresistance of prostate cancer and could be a potential therapeutic target.
Liu, Xiao-Qi,Jiang, Rong,Li, Si-Qi,Wang, Jing,Yi, Fa-Ping Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Prostate cancer is the most common cancer in men. In this study, we investigated immune responses of cytotoxic T lymphocytes (CTLs) against TRAMP-C2 prostate cancer cells after activation by dendritic cells (DCs) loaded with TRAMP-C2 freeze-thaw antigen and/or PEP-3 peptide in vitro. Bone marrow-derived DC from the bone marrow of the C57BL/6 were induced to mature by using the cytokine of rhGM-CSF and rhIL-4, and loaded with either the freeze-thaw antigen or PEP-3 peptide or both of them. Maturation of DCs was detected by flow cytometry. The killing efficiency of the CTLs on TRAMP-C2 cells were detected by flow cytometry, CCK8, colony formation, transwell migration, and wound-healing assay. The levels of the IFN-${\gamma}$, TNF-${\beta}$ and IL-12 were measured by enzyme-linked immunosorbent assay (ELISA). Compared with the unloaded DCs, the loaded DCs had significantly increased expression of several phenotypes related to DC maturation. CTLs activated by DCs loaded with freeze-thaw antigen and PEP-3 peptide had more evident cytotoxicity against TRAMP-C2 cells in vitro. The secretion levels of IFN-${\gamma}$, TNF-${\beta}$ and IL-12, secreted by DCs loaded with antigen and PEP-3 and interaction with T cells, were higher than in the other groups. Our results suggest that the CTLs activated by DCs loaded with TRAMP-C2 freeze-thaw antigen and PEP-3 peptide exert a remarkable killing efficiency against TRAMP-C2 cells in vitro.
Qi-Xian Lian,Jian-Feng Liu,Mao-Fa Yang,Chang Han 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.3
The leafhopper Cicadella viridis (Hemiptera: Cicadellidae), a sap-sucking insect, is a notorious pest of fruit trees and seedlings. They harbor “Candidatus sulcia merii” which is an obligatory symbiotic bacteriumhoused in a special organ called the bacteriome. In this study universal eubacterial primers 27F and 1513R were used to amplify approximately 1462 bp of symbiotic bacteria 16S rRNA gene fromC. viridis. Cloning, sequencing, and phylogenetic analysis targeting the 16S rRNA gene revealed the presence of bacteria stably associated with C. viridis, and a Rickettsia endosymbiont was detected for the first time in this species. Rickettsia endosymbiont localization was studied using quantitative PCR which showed that it was found in all developmental stages. It was also co-localized in the bacteriomes, ovaries, testes, guts, and salivary glands. By an antibiotic treatment, the antibiotic-treated insects exhibited lower Rickettsia infection density than the untreated
Behavior of circular concrete-filled steel tubular columns under pure torsion
Fa-Xing Ding,QIANG FU,Bing Wen,Qi-shi Zhou,Xue-mei Liu 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.26 No.4
Concrete-filled steel tubular (CFT) columns are commonly used in engineering structures and always subjected to torsion in practice. This paper is thus devoted to investigate the mechanical behavior of circular CFT columns under pure torsion.3D finite element models based on reasonable material constitutive relation were established for analyzing the load-strain (<i>T-–γ</i>) curves of circular CFT columns under pure torsion. The numerical simulation indicated that local bulking of the steel tube in CFT columns was prevented and the shear strength and ductility of the core concrete were significantly improved due to the confinement effect between the steel tube and the core concrete. Based on the results, formulas to predict the torsional ultimate bearing capacity of circular CFT columns were proposed with satisfactory correspondence with experimental results. Besides, formulas of composite shear stiffness and the overall process of the <i>T-–γ</i> relation of circular CFT columns under pure torsion were proposed.
Flexural stiffness of steel-concrete composite beam under positive moment
Fa-Xing Ding,Jing Liu,Xuemei Liu,Feng-Qi Guo,Li-Zhong Jiang 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.20 No.6
This paper investigates the flexural stiffness of simply supported steel-concrete composite I-beams under positive bending moment through combined experimental, numerical, and different standard methods. 14 composite beams are tested for experimental study and parameters including shear connection degree, transverse and longitudinal reinforcement ratios, loading way are also investigated. ABAQUS is employed to establish finite element (FE) models to simulate the flexural behavior of composite beams. The influences of a few key parameters, such as the shear connection degree, stud arrangement, stud diameter, beam length, loading way, on the flexural stiffness is also studied by parametric study. In addition, three widely used standard methods including GB, AISC, and British standards are used to estimate the flexural stiffness of the composite beams. The results are compared with the experimental and numerical results. The findings have provided comprehensive understanding of the flexural stiffness and the modelling of the composite beams. The results also indicate that GB 50017-2003 could provide better results in comparison to the other standards.