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Nur Fathonah Sadek,Nancy Dewi Yuliana,Endang Prangdimurti,Bambang Pontjo Priosoeryanto,Slamet Budijanto 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.7
Plant sterols in their free forms are known to inhibit colon cancer. Whether these activities persist when compounds are incorporated into processed food is not reported yet. This study aimed to test the ability of plant sterol esters (PSE) incorporated into a nonpuffed extruded food (NPE) model to inhibit colon carcinogenesis. PSE was added into NPE at four concentrations (0.0%, 0.7%, 1.4%, and 2.1%). PSE-NPE activity was tested in azoxymethane/dextran sodium sulfate-induced Balb/c mice. The groups given PSE-NPE did not show any colon tumor formation. Immunohistochemistry results revealed that the group fed with 1.4% PSE had the lowest histoscore for cyclooxygenase-2 expression and the highest histoscore for cleaved caspase-3, cleaved caspase-8, and cleaved caspase-9expressions. The results of this study indicated that even after incorporation into a food system, which is processed using high pressure and temperature, PSE retained its chemopreventive activity. The proposed mechanisms are by suppressing inflammation and inducing apoptosis.
Dahlia Sutanto,Mieke Hemiawati Satari,Bethy S. Hernowo,Bambang Pontjo Priosoeryanto,Rifki Septawendar,Lia A. T. W. Asri,Bambang Sunendar Purwasasmita 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.5
Geopolymer and carbonated apatite are potential materials for dental restoration. We reported the synthesis of geopolymer– carbonated apatite nanocomposite, highlighting the infl uence of trace elements in carbonated apatite toward mechanical, leachability and cytotoxicity properties. Various carbonated apatites were combined with metakaolin, followed by geopolymerization. The study revealed that with addition of Mg 2+ and Sr 2+ , the geopolymer–carbonated apatite nanocomposites have the tendency to have lower mechanical properties. Geopolymer and geopolymer–carbonated apatite showed higher hardness, compressive strength, and modulus elasticity compared with geopolymer–carbonated apatite containing Mg 2+ and/ or Sr 2+ . Nevertheless, all samples showed mechanical properties that could be applied as dental restoration materials. Leaching assay confi rmed the release of Na + in all samples, originating from unreacted alkali activator. The Na + concentration decreased signifi cantly after 96 h of total washing, with the lowest value of 1 ppm. Cytotoxicity test was evaluated toward mouse embryonic fi broblast cells, indicating that all samples were not toxic to cells.