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RISS 인기검색어
- 검색키워드
- 저자 : Bethy S. Hernowo (검색결과 3 건)
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Correlation between EGFR Expression and Radiosensitivity in Cervical Adenocarcinoma Cases
Hernowo, Bethy S,Suryanti, Sri,Wibisono, Fennisia Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: Most of the cervical cancer patients, including those with cervical adenocarcinomas, come at advanced stage in the developing world so its mortality is high. Radiotherapy is one of the treatment modality for advanced stage cervical adenocarcinomas, but its efficacy depends on several prognostic factors such as the stage, histopathology, presence of organ dysfunction and expression of cellular biology markers mainly involve in cell proliferation such as the epidermal growth factor receptor (EGFR). Some research indicates that activation of EGFR in malignancy (including cervical cancer) correlates with aggressive behavior, a poor prognosis and decreasing sensitivity of radiotherapy. However, the combination between targeted therapies and radiotherapy are innovative approaches which may provide a good result. This study aimed to assess any correlation between expression of EGFR and response to radiotherapy in cervical adenocarcinoma cases. Materials and Methods: A total of 32 women were registered in a retrospective study period January 2007 and May 2014. Paraffin blocks from these patients were processed by classical histological techniques and for immunohistochemical staining of EGFR, scoring being accomplished according to the immunoreactive scoring (IRS) of Remmele and Stegner. Results: Among the studied molecular factors, there was significant correlation expression of EGFR with poor response to radiotherapy (p=0.0001). Conclusions: The result of this study showed a significant correlation between expression of EGFR and sensitivity of radiation in cervical adenocarcinoma cases. Further research is necessary to obtain information about new therapeutic management.
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The Major Role of NF-κB in the Depth of Invasion on Acral Melanoma by Decreasing CD8+ T Cells
Hermin Aminah Usman,Bethy S. Hernowo,Maringan Diapari Lumban Tobing,Reti Hindritiani 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.3
Background: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor κB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in the inflammatory process and in tumorigenesis. CD8+ T cells have cytotoxic properties important in the elimination of tumors. However, inhibitory receptors on the cell surface will bind to programmed death-ligand 1 (PD-L1), causing CD8+ T cells to lose their ability to initiate an immune response. This study analyzed the association of NF-κB and PD-L1 expression levels and CD8+ T-cell counts with depth of invasion of acral MM, which may be a predictor of aggressiveness related to an increased risk of metastasis. Methods: A retrospective cross-sectional study was conducted in the Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital using 96 cases of acral melanoma. Immunohistochemical staining was performed on paraffin blocks using anti–NF-κB, –PD-L1, and –CD8 antibodies and invasion depth was measured using dotSlide-imaging software. Results: The study showed significant associations between the individual expression of NF-κB and PD-L1 and CD8+ T-cell number, with MM invasion depth. NF-κB was found to be a confounding variable of CD8+ T-cell number (p < .05), but not for PD-L1 expression (p = .154). Through multivariate analysis it was found that NF-κB had the greatest association with the depth of invasion (p < .001), whereas PD-L1 was unrelated to the depth of invasion because it depends on the number of CD8+ T cells (p = .870). Conclusions: NF-κB plays a major role in acral MM invasion, by decreasing the number of CD8+ T cells in acral MM.
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Dahlia Sutanto,Mieke Hemiawati Satari,Bethy S. Hernowo,Bambang Pontjo Priosoeryanto,Rifki Septawendar,Lia A. T. W. Asri,Bambang Sunendar Purwasasmita 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.5
Geopolymer and carbonated apatite are potential materials for dental restoration. We reported the synthesis of geopolymer– carbonated apatite nanocomposite, highlighting the infl uence of trace elements in carbonated apatite toward mechanical, leachability and cytotoxicity properties. Various carbonated apatites were combined with metakaolin, followed by geopolymerization. The study revealed that with addition of Mg 2+ and Sr 2+ , the geopolymer–carbonated apatite nanocomposites have the tendency to have lower mechanical properties. Geopolymer and geopolymer–carbonated apatite showed higher hardness, compressive strength, and modulus elasticity compared with geopolymer–carbonated apatite containing Mg 2+ and/ or Sr 2+ . Nevertheless, all samples showed mechanical properties that could be applied as dental restoration materials. Leaching assay confi rmed the release of Na + in all samples, originating from unreacted alkali activator. The Na + concentration decreased signifi cantly after 96 h of total washing, with the lowest value of 1 ppm. Cytotoxicity test was evaluated toward mouse embryonic fi broblast cells, indicating that all samples were not toxic to cells.
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