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- 저자 : Prerna Chaudhary (검색결과 3 건)
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Diverse roles of arrest defective 1 in cancer development
Prerna Chaudhary,Eunyoung Ha,Tam Thuy Lu Vo,Ji Hae Seo 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.12
Arrest defective 1 is an acetyltransferase thatacetylates N-terminal amino acid or internal lysine residuesof its target proteins. By acetylating its target proteins,ARD1 plays roles in many cellular activities, including proliferation,differentiation, autophagy, and apoptosis. In recentyears, a number of investigations have emerged reportingthe dysregulated expression of ARD1 in different types ofcancer, including lung, liver, pancreas, breast, prostate, andcolon cancer. Furthermore, the expression level of ARD1 incancer tissues has been correlated with the progression andmetastasis of the cancer and the survival of cancer patients. Consequently, mechanistic studies have revealed that ARD1-mediated protein acetylation plays an important role in modulatingseveral cellular events that are important for cancerdevelopment, such as cell cycle progression, cell death, andmigration. On the basis of this evidence, targeting of ARD1has been proposed as a promising avenue for the developmentof novel cancer therapeutics. This review summarizesthe biological functions of ARD1 in different types of cancerand provides a deep insight into the biochemical activitiesof ARD1 during tumor progression.
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하동호,Phuong Mai Thi,Prerna Chaudhary,정지헌 한국고분자학회 2019 Macromolecular Research Vol.27 No.10
Primary hepatocytes constitute 60-80% of liver where they play a vital role in metabolism, synthesis and storage such as vitamins, carbohydrates, proteins. When hepatocytes are grown in vitro as monolayers, they rapidly lose their phenotypic characteristics and functional abilities. We successfully developed a threedimensional (3D) culturing system for rat primary hepatocytes using micropatterned multi-well plates. The efficiency, morphology, cell viability and functionality (albumin secretion and urea synthesis) of hepatocyte spheroids produced by 3D and monolayer culture were compared. In monolayer culture, hepatocytes did not maintain an intact morphology and their viabilities started to decline after 4 days. On the other hand, hepatocyte spheroids were prepared with various numbers of single hepatocytes. It was confirmed that 150 hepatocytes per spheroid were optimum with incorporation efficiencies of around 95% as well as obtained spheroids were more homogenous in shape and size. Additionally, the secretion of albumin and production of urea by these spheroids were significantly greater than those of cells in monolayer culture. Our results show the described method could potentially be used in liver tissue regeneration, new drug discovery or toxicology studies.
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Yonghwa Baek(백용화),Xinlin Li,Prerna Chaudhary,Chan Eon Park(박찬언),Sung Soo Han(한승수),Tae Kyu An(안태규),Se Hyun Kim(김세현) 한국고분자학회 2019 폴리머 Vol.43 No.1
폴리이미드는 대부분의 고분자 필름의 단점으로 지적되고 있는 열적, 화학적 취약성을 극복할 수 있는 좋은 재료이다. 이렇게 우수한 특성에도 불구하고, 폴리이미드는 전구체인 폴리아믹산의 낮은 용해도로 인해 가공성이 좋지 않을 뿐만 아니라, 특유의 황토빛을 띠는 성질로 인하여 디스플레이 분야로의 응용이 제한적이다. 본 연구에서는 폴리아믹산의 디아민 단량체에 시아노기(-CN)를 도입하여, 폴리이미드의 우수한 내화학성, 내열성, 전기적특성을 그대로 지니면서도 전자 전이 복합화에 의해 황토색 빛을 띠는 현상을 극복하여 무색 투명한 형태를 띠는 폴리이미드 필름인 poly(2-cyano-p-phenylene pyromellitimide; cy-PPI)를 제조하고 유기전계효과 트랜지스터의 절연층으로 적용시켜보았다. cy-PPI 박막은 우수한 절연특성을 보여주었을 뿐만 아니라, 그 위에서 반도체 결정이 잘 성장하게 해주었다. 그 결과, cy-PPI 절연층이 도입된 펜타센 트랜지스터 소자에서 0.15 ㎠/Vs의 전하이동도와 1.2×10<SUP>5</SUP>의 점멸비의 우수한 전기적 성능을 나타내었다. Polyimides are attractive choices for the formation of films in various industries due to their excellent mechanical, thermal, and chemical stabilities. However, the insolubility of their precursors (poly(amic acid); PAA) and the intrinsically poor optical transmittance of polyimide films have impeded their applications in various fields. In this study, we present newly synthesized cyanated polyimide gate dielectrics, poly(2-cyano-p-phenylene pyromellitimide) (cy-PPI), and applied them to organic field-effect transistors (OFETs). The strongly electron-withdrawing cyano groups of PAA played a critical role in improving the solubility and transparency of the polyimide. The solution-processed cy-PPI films exhibited good dielectric properties, and their smooth surfaces led to a better crystalline morphology in the pentacene film grown over their surfaces. As a result, the good electrical properties (0.15 ㎠/Vs of field-effect mobility and 1.2×10<SUP>5</SUP> of on/off ratio) were achieved for the pentacene-based cy-PPI OFETs.
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