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- 저자 : Praveen Rajendran (검색결과 2 건)
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Synthesis of Cobalt Sulfide–Graphene (CoS/G) Nanocomposites for Supercapacitor Applications
Ramachandran, Rajendran,Felix, Sathiyanathan,Saranya, Murugan,Santhosh, Chella,Velmurugan, Venugopal,Ragupathy, Bala Praveen Chakkravarthy,Soon Kwan Jeong,Grace, Andrews Nirmala IEEE 2013 IEEE TRANSACTIONS ON NANOTECHNOLOGY Vol.12 No.6
<P>Cobalt sulfide (CoS) and graphene nanocomposites were prepared from cobalt nitrate, thioacetamide, and graphene as starting materials in the presence of poly(vinylpyrrolidone) as surfactant. Furthermore, its morphology and properties were characterized by X-ray diffraction (XRD), field-emission scanning electron microscope, diffusive reflectance ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and electrochemical measurements. The XRD reveals the amorphous nature of the nanocomposites. The as-prepared nanocomposites were tested for its supercapacitance property by cyclic voltammetric (CV) experiment in 6M KOH electrolyte. CV was performed at a potential range of 0 to -0.8 V at different scan rates, and results show an excellent capacitive behavior of the nanocomposites. A maximum specific capacitance of 2423.3 F/g was obtained at a scan rate of 5 mV/s.</P>
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Targeting Epigenetic ‘Readers’ with Natural Compounds for Cancer Interception
Elisabetta Damian,Munevver N. Duran,Nivedhitha Mohan,Praveen Rajendran,Roderick H. Dashwood 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.4
Natural compounds from diverse sources, including botanicals and commonly consumed foods and beverages, exert beneficial health effects via mechanisms that impact the epigenome and gene expression during disease pathogenesis. By targeting the socalled epigenetic ‘readers’, ‘writers’, and ‘erasers’, dietary phytochemicals can reverse abnormal epigenome signatures in cancer cells and preneoplastic stages. Thus, such agents provide avenues for cancer interception via prevention or treatment/therapeutic strategies. To date, much of the focus on dietary agents has been directed towards writers (e.g., histone acetyltransferases) and erasers (e.g., histone deacetylases), with less attention given to epigenetic readers (e.g., BRD proteins). The drug JQ1 was developed as a prototype epigenetic reader inhibitor, selectively targeting members of the bromodomain and extraterminal domain (BET) family, such as BRD4. Clinical trials with JQ1 as a single agent, or in combination with standard of care therapy, revealed antitumor efficacy but not without toxicity or resistance. In pursuit of second-generation epigenetic reader inhibitors, attention has shifted to natural sources, including dietary agents that might be repurposed as ‘JQ1-like’ bioactives. This review summarizes the current status of nascent research activity focused on natural compounds as inhibitors of BET and other epigenetic ‘reader’ proteins, with a perspective on future directions and opportunities. Key Words Bromodomains, Chromodomains, Cancer prevention, Epigenetics, Natural compounds
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