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Xu, Xiao-Hua,Peng, Xue-Hong,Yu, Ping,Xu, Xiao-Yuan,Cai, Er-Hui,Guo, Pi,Li, Ke Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Neoadjuvant chemotherapy for resectable esophageal carcinoma has been a focus of study, but no agreement has been reached on clinical randomized controlled trials and relevant systematic evaluation. The purpose of this study was to perform a meta-analysis on published randomized controlled trials (RCTs) that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Medline and manual searches was conducted in PubMed, ASCO (American Society of Clinical Oncology) meeting summary, Embase, the Cochrane Library (up to October 2010), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database, Wanfang Database. The selection contents were to identify all published and unpublished RCTs that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Sixteen RCTs which included 2,594 patients were selected. The risk ratio (RR) (95% confidence interval [CI]; P value), expressed as neoadjuvant chemotherapy and surgery versus surgery alone (treatment versus control), was 1.02 (0.95, 1.10; P=0.54) for 1-year survival, 1.29 (1.13, 1.47; P=0.0001) for 3-year survival, 1.31 (1.13, 1.51; P=0.0003) for 5-year survival, 1.00 (0.95, 1.04; P= 0.85) for rate of resection and 0.89 (0.64, 1.23; P=0.48) for operative mortality. The results showed that neoadjuvant chemotherapy for resectable esophageal carcinoma can raise the overall survival rate of patients with esophageal carcinoma, but it does not affect treatment-related mortality.
Jin, An,Li, Xue,Zhu, Yun-Yun,Yu, Heng-Yi,Pi, Hui-Fang,Zhang, Peng,Ruan, Han-Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Three new alkaloids, $2{\alpha}$-hydroxy-6-O-n-butyloduline, O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine (1-3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-2'-methylbenzene-3',6'-diol (14), along with ten known alkaloids (4-13), were isolated from the bulbs of Lycoris aurea collected from Huaihua County of Hunan Province, China. Their structures were elucidated by spectroscopic methods including HRESIMS, UV, IR, and NMR. All the isolated compounds were tested for their neuroprotective effects against $CoCl_2$ and $H_2O_2$-induced SH-SY5Y cell death. Compounds 1-7 and 10 exhibited significant neuroprotective effects against $CoCl_2$-induced SH-SY5Y cell injury, while compounds 1-5, 7, 10 and 12 showed obvious neuroprotective effects against $H_2O_2$-induced SH-SY5Y cell death.
Yun-Yun Zhu,Xue Li,Heng-Yi Yu,Yu-Fang Xiong,Peng Zhang,Hui-Fang Pi,Han-Li Ruan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Three novel alkaloids (1–3), together withnineteen known ones (4–22), were isolated from the bulbsof Lycoris longituba. Their structures were elucidated onthe basis of extensive spectroscopic analyses, which belongto several Amaryllidaceae alkaloid skeletons. Amongthem, the harmane-type alkaloids (the new compound 1and the known compounds 5, 6 and 7) were found for thefirst time from Lycoris genus. The isolates were tested fortheir neuroprotective activities against CoCl2, H2O2 andAb25–35-induced SH-SY5Y cell injuries, and the majorityof them exhibited neuroprotective activities of differentdegrees. The acetylcholinesterase (AChE) inhibitoryactivities of the isolated alkaloids were also evaluated,while compounds 12, 14–20 and 22 exhibited extremelysignificant AChE inhibitory activities.
An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.