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Insights into ovarian cancer care: report from the ANZGOG Ovarian Cancer Webinar Series 2020
Andreas Obermair,Philip Beale,Clare L Scott,Victoria Beshay,Ganessan Kichenadasse,Bryony Simcock,James Nicklin,Yeh Chen Lee,Paul Cohen,Tarek Meniawy 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.6
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Steps in Moving Evidence-Based Health Informatics from Theory to Practice
Michael Rigby,Farah Magrabi,Philip Scott,Persephone Doupi,Hannele Hypponen,Elske Ammenwerth 대한의료정보학회 2016 Healthcare Informatics Research Vol.22 No.4
Objectives: To demonstrate and promote the importance of applying a scientific process to health IT design and implementation,and of basing this on research principles and techniques. Methods: A review by international experts linked to the IMIA Working Group on Technology Assessment and Quality Development. Results: Four approaches are presented, linking to the creation of national professional expectations, adherence to research-based standards, quality assurance approaches to ensure safety, and scientific measurement of impact. Conclusions: Solely marketing- and aspiration-based approaches to health informatics applications are no longer ethical or acceptable when scientifically grounded evidence-based approaches are available and in use.
Control of inflammation by stromal Hedgehog pathway activation restrains colitis
Lee, John J.,Rothenberg, Michael E.,Seeley, E. Scott,Zimdahl, Bryan,Kawano, Sally,Lu, Wan-Jin,Shin, Kunyoo,Sakata-Kato, Tomoyo,Chen, James K.,Diehn, Maximilian,Clarke, Michael F.,Beachy, Philip A. National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.47
<P>Inflammation disrupts tissue architecture and function, thereby contributing to the pathogenesis of diverse diseases; the signals that promote or restrict tissue inflammation thus represent potential targets for therapeutic intervention. Here, we report that genetic or pharmacologic Hedgehog pathway inhibition intensifies colon inflammation (colitis) in mice. Conversely, genetic augmentation of Hedgehog response and systemic small-molecule Hedgehog pathway activation potently ameliorate colitis and restrain initiation and progression of colitis-induced adenocarcinoma. Within the colon, the Hedgehog protein signal does not act directly on the epithelium itself, but on underlying stromal cells to induce expression of IL-10, an immune-modulatory cytokine long known to suppress inflammatory intestinal damage. IL-10 function is required for the full protective effect of small-molecule Hedgehog pathway activation in colitis; this pharmacologic augmentation of Hedgehog pathway activity and stromal IL-10 expression are associated with increased presence of CD4(+) Foxp3(+) regulatory T cells. We thus identify stromal cells as cellular coordinators of colon inflammation and suggest their pharmacologic manipulation as a potential means to treat colitis.</P>
Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer
Wall Steven W.,Sanchez Lilia,Tuttle Kelly Scribner,Pearson Scott J.,Soma Shivatheja,Wyatt Garhett L.,Carter Hannah N.,Jenschke Ramsey M.,Tan Lin,Martinez Sara A.,Lorenzi Philip L.,Gohil Vishal M.,Rijn 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Dysregulation of cellular metabolism is a hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. Here, we show that the breast tumor suppressor gene SIM2 promotes mitochondrial oxidative phosphorylation (OXPHOS) using breast cancer cell line models. Mechanistically, we found that SIM2s functions not as a transcription factor but localizes to mitochondria and directly interacts with the mitochondrial respiratory chain (MRC) to facilitate functional supercomplex (SC) formation. Loss of SIM2s expression disrupts SC formation through destabilization of MRC Complex III, leading to inhibition of electron transport, although Complex I (CI) activity is retained. A metabolomic analysis showed that knockout of SIM2s leads to a compensatory increase in ATP production through glycolysis and accelerated glutamine-driven TCA cycle production of NADH, creating a favorable environment for high cell proliferation. Our findings indicate that SIM2s is a novel stabilizing factor required for SC assembly, providing insight into the impact of the MRC on metabolic adaptation and breast cancer progression.