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Ismail Konus,Ercan Ozsoy,Peykan Turkcuoglu,Sinan Emre,Fulya Duman 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.5
Purpose: To evaluate the effects of idiopathic infantile nystagmus (IN) and bilateral ametropic amblyopia on metabolitesin the occipital cortex by magnetic resonance spectroscopy. Methods: The children included in this prospective study were divided into three groups. Group 1 consisted of11 patients with idiopathic IN, group 2 consisted of 10 patients with bilateral ametropic amblyopia and group3 consisted of nine normal children. A single-voxel magnetic resonance spectroscopy examination was performedby placing a region of interest on the occipital cortex of each participant. N-acetyl aspartate (NAA),creatine (Cr) and choline (Cho) concentrations were measured in the occipital cortex. This was followed bycalculating and comparing the NAA/Cr and Cho/Cr ratios between the three groups. The Kruskal-Wallis test,Mann-Whitney U-test, and chi-square test were used for statistical analysis. Results: There was no statistically significant difference in NAA/Cr ratios between patients with idiopathic INand normal children, but there was a statistically significant difference between these groups when Cho/Crratios were compared; the ratio was higher in the idiopathic IN group. There were no statistically significant differencesin NAA/Cr or Cho/Cr ratios between patients with bilateral ametropic amblyopia and normal children. Conclusions: Our findings suggest that the neurochemical profile of the occipital cortex is partially affected byidiopathic IN, but not by bilateral ametropic amblyopia.