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Yifan Xu,Zhongyuan Liu,Kunlun Wang,Chunyao Niu,Pengfei Yuan,Jin You Zheng,Young Soo Kang,Xiao Li Zhang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
General modification that utilizes insoluble tungstic acid or highly toxic hydrofluoric acid to improvecharge separation and transfer in TiO2 results in considerable issues such as uneven doping, significantimpacts on particle size and morphology, as well as environmental hazards. In the present work, an environmentalbenign one-pot dual-modification approach was demonstrated that uses soluble sodium tungstateand only trace-level sodium fluoride as replacements. The photoactivity efficiency for decolorationof methylene blue (MB) solution was improved by 33.6% and 119.5% under ultraviolet and visible light,respectively. Meanwhile, the photocurrent density reached an enhancement by 181.2% by this dualmodification. The dual-modification had negligible influence on the crystal structure and the surface areaof the TiO2 nanoparticles. Density functional calculation suggested the remarkable improvements of thephotocatalysis of TiO2 can be ascribed to the rapid charge separation and transfer owing to the downshiftof conduction band from the tungsten doping and localized spatial charge separation from the surfacefluorination enabled by the dual-modification approach.
Qingkun Gao,Ke An,Zhaoya Gao,Yanzhao Wang,Changmin Ding,Pengfei Niu,Fuming Lei The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4
Numerous studies have revealed the importance of tumor-derived exosomes in rectal cancer (RC). This study aims to explore the influence of tumor-derived exosomal integrin beta-1 (ITGB1) on lung fibroblasts in RC along with underlying mechanisms. Exosome morphology was observed using a transmission electron microscope. Protein levels of CD63, CD9, ITGB1, p-p65 and p65 were detected using Western blot. To determine ITGB1's mRNA expression, quantitative real-time polymerase chain reaction was used. Moreover, levels of interleukin (IL)-8, IL-1β, and IL-6 in cell culture supernatant were measured via commercial ELISA kits. ITGB1 expression was increased in exosomes from RC cells. The ratio of p-p65/p65 as well as levels of interleukins in lung fibroblasts was raised by exosomes derived from RC cells, while was reduced after down-regulation of exosomal ITGB1. The increased ratio of p-p65/p65 as well as levels of pro-inflammatory cytokines caused by exosomes from RC cells was reversed by the addition of nuclear factor kappa B (NF-κB) inhibitor. We concluded that the knockdown of RC cells-derived exosomal ITGB1 repressed activation of lung fibroblasts and the NF-κB pathway in vitro.