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Peng Qu,Guangqiang Fang,He Kong,Zhengli Cao,Jia Ma,Zhiyi Wang,An-Fu Guo,Shaoqing Wang,Xunjin Li,Xinran Shan 한국섬유공학회 2023 Fibers and polymers Vol.24 No.9
Shape memory epoxy polymer reinforced by single-ply weave fabric (SMEP-W) possesses high specific stiffness, good foldability, and satisfactory shape memory capability. These advantages make them promising materials for deployable space structures and increasingly attract research interests. Understanding the influence of weave structures on static and dynamic mechanical properties is crucial to structural design and mechanical response prediction. In this paper, a recently developed SMEP-W was prepared. The static shear experiments were conducted through modified shear test fixtures, and the stress field under static shear load was simulated through a multi-scale numerical modelling method. The dynamic mechanical analysis was carried out to evaluate the shape memory capability. SMEP-W shows nonlinear mechanical behavior under in-plane shear load, especially for the one with less thread count. The increase in the number of threads enhances the constraints between warp yarns and weft yarns, leading to an increase in shear modulus and reducing the scattering of static mechanical properties. The stress distribution on the yarns has the characteristic of center symmetry. High-stress regions appear on the overlapping surface of the crossover regions. Compared with shape memory epoxy polymer (SMEP), the glass transition temperature and damping coefficient of SMEP-W are significantly reduced, and the stiffness is remarkably enhanced. The difference in thread count between warp direction and weft direction does not notably affect the glass transition temperature and tan δ, but has a remarkable influence on the storage modulus. The present work could provide basic observation for understanding the influence of thread count on the shear mechanical properties and dynamic mechanical properties of SMEP-W.
Chen Peng,Luo Xiaojun,Dai Guanqi,Jiang Yuchuan,Luo Yue,Peng Shuang,Wang Hao,Xie Penghui,Qu Chen,Lin Wenyu,Hong Jian,Ning Xue,Li Aimin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Dexmedetomidine (DEX) is an anesthetic that is widely used in the clinic, and it has been reported to exhibit paradoxical effects in the progression of multiple solid tumors. In this study, we sought to explore the mechanism by which DEX regulates hepatocellular carcinoma (HCC) progression underlying liver fibrosis. We determined the effects of DEX on tumor progression in an orthotopic HCC mouse model of fibrotic liver. A coculture system and a subcutaneous xenograft model involving coimplantation of mouse hepatoma cells (H22) and primary activated hepatic stellate cells (aHSCs) were used to study the effects of DEX on HCC progression. We found that in the preclinical mouse model of liver fibrosis, DEX treatment significantly shortened median survival time and promoted tumor growth, intrahepatic metastasis and pulmonary metastasis. The DEX receptor (ADRA2A) was mainly expressed in aHSCs but was barely detected in HCC cells. DEX dramatically reinforced HCC malignant behaviors in the presence of aHSCs in both the coculture system and the coimplantation mouse model, but DEX alone exerted no significant effects on the malignancy of HCC. Mechanistically, DEX induced IL-6 secretion from aHSCs and promoted HCC progression via STAT3 activation. Our findings provide evidence that the clinical application of DEX may cause undesirable side effects in HCC patients with liver fibrosis.
Finite element generalized tooth contact analysis of double circular arc helical gears
Qu, Wentao,Peng, Xiongqi,Zhao, Ning,Guo, Hui Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.4
This paper investigates the load sharing of double circular arc helical gears considering the influence of assembly errors. Based on a load sharing formulae, a three-dimensional finite element tooth contact analysis (TCA) is implemented with commercial software package ANSYS. The finite element grid for the double circular arc gear contact model is automatically generated by using the APDL (ANSYS Parameter Design Language) embedded in ANSYS. The realistic rotation of gears is achieved by using a coupling degree-of-freedom method. Numerical simulations are carried out to exemplify the proposed approach. The distribution of contact stress and bending stress under specific loading conditions are computed and compared with those obtained from Hertz contact theory and empirical formulae to demonstrate the efficiency of the proposed load sharing calculation formulae and TCA approach.
Qu, Hong-Hong,Cui, Li-Hong,Wang, Ke,Wang, Peng,Song, Chun-Hua,Wang, Kai-Juan,Zhang, Jian-Ying,Dai, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. This study with 381 esophageal cancer patients and 432 healthy controls was conducted to examine the association of MTHFR C677T and A1298C polymorphisms with susceptibility to esophageal cancer (EC) in a Chinese population. Compared with the CC genotype of MTHFR C677T, subjects carrying homozygote TT and variant genotypes (CT+TT) demonstrated reduced risk of EC with adjusted ORs (95% CI) of 0.44 (0.28-0.71) and 0.57 (0.37-0.88), respectively. However, no association was found between the MTHFR A1298C polymorphism and the risk of EC. Comparing to haplotype CA, haplotypes TA and TC could reduce the susceptibility to EC with adjusted ORs (95% CI) of 0.61(0.47-0.79) and 0.06 (0.01-0.43), respectively. In conclusion, the present study suggested that the MTHFR C677T polymorphism can markedly influence the risk of EC in Chinese.
Qu, Jiaqi,Wang, Zhendong,Du, Peng Council on Tall Building and Urban Habitat Korea 2021 International journal of high-rise buildings Vol.10 No.1
Since 2006, the number of completed high-rise buildings over 200 meters have increased rapidly. Although there were some short-term cyclical troughs, the overall trend has still been growing. No longer constrained by technological limits, the development of high-rise buildings now depends on cooperation and compromise between social, economic, and political factors. This article extracts statistical data from the Council on Tall Buildings and Urban Habitat (CTBUH) to focus on the completion of high-rise buildings of 200 meters and above over the past 20 years from 2000 to 2019. Similarities and differences in the number, distribution, and function of high-rise buildings are analyzed, The paper also compares the impact of different political and economic environments on the development trends of high-rise buildings in China, the United States and the UAE.
Finite element generalized tooth contact analysis of double circular arc helical gears
Wentao Qu,Xiongqi Peng,Ning Zhao,Hui Guo 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.4
This paper investigates the load sharing of double circular arc helical gears considering the influence of assembly errors. Based on a load sharing formulae, a three-dimensional finite element tooth contact analysis (TCA) is implemented with commercial software package ANSYS. The finite element grid for the double circular arc gear contact model is automatically generated by using the APDL (ANSYS Parameter Design Language) embedded in ANSYS. The realistic rotation of gears is achieved by using a coupling degree-of-freedom method. Numerical simulations are carried out to exemplify the proposed approach. The distribution of contact stress and bending stress under specific loading conditions are computed and compared with those obtained from Hertz contact theory and empirical formulae to demonstrate the efficiency of the proposed load sharing calculation formulae and TCA approach.
Yan Qu,Chenjiang Guo,Xia Zhao,Wencan Peng,Jun Ding 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.4
Phase-only optimization of asymmetric multiple beams reflectarray with single feed is investigated in this paper. The conventional design approaches are first reviewed. Secondly, for design of asymmetric multiple beams reflectarray with arbitrary gain levels and beam directions, a general method based on invasive weed optimization is proposed. Then, practical considerations for applying the proposed method to design multiple beams reflectarray are talked over. For illustrating the effectiveness of the proposed method, several multiple beams design cases with different design requirements are optimized through this method, and the optimized results are analyzed through simulation approach based on array theory. The simulation results show that the optimized cases demonstrate the satisfactory multiple beams performance.