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Label-Free Electrical Biosensor Arrays: A New Challenge for TFT Technology
Pedro Estrela,Peng Li,Simon D. Keighley,Piero Migliorato 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.1
Biotechnology is in great need of low-cost intelligent biochips capable of massive parallel detection to be used in portable instrumentation. One way this may be achieved is to exploit mature semiconductor technologies for the development of biosensor arrays. We review here two highly promising techniques for label-free electrical detection of biomolecular interactions: potentiometric and electrochemical impedance spectroscopy. Thin film transistor technology can play an important role in the development of these techniques in biosensor microarrays.
Biologically Sensitive Field-Effect Devices using Polysilicon TFTs
Piero Migliorato,Pedro Estrela,Andrew G. Stewart,Simon D. Keighley 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I
This paper presents a review of recent developments in the detection of biomolecular interactions with field-effect devices. Ion-sensitive field-effect transistors (ISFETs) and enzyme field-effect transistors (EnFETs), based on polycrystalline silicon (poly-Si) TFTs, are discussed. Label-free electrical detection of DNA hybridization has been achieved by a new method, by using MOS capacitors or poly-Si TFTs. The method can in principle be extended to other chemical or biochemical systems, such as proteins and cells.o