Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

Panda, Prabhudutta,Panda, DP,Panda, PK,Nayak, SS Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.7 No.5

The present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.) fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and anti-inflammatory effects using various animal models The dried, powdered leaves of, P. fascicularis were extracted successively with petroleum ether ($60\;-\;80^{\circ}C$) and chloroform in soxhlet apparatus. The chloroform extract (yield 21.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Two models were employed to investigate the effects on nociception, the tail immersion and hot plate method in Swiss albino mice and anti inflammatory effect were investigated by employing the carrageenan induced rat paw edema test in. adult Wister albino rats. Behavioral study was investigated by elevated plus maze method in Swiss albino mice. Results were revealed that the PFCE was found significant antinociceptive effect (P < 0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and produced remarkable antiinflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the PFCE has no significant anxiolysis effect when used orally. It concludes that, PFCE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.

Numerical modeling and prediction of adhesion failure of adhesively bonded composite T-Joint structure

Subhransu K Panda,Pradeep K Mishra,Subrata K. Panda 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.74 No.6

This study is reported the adhesion failure in adhesive bonded composite and specifically for the T-joint structure. Three-dimensional finite element analysis has been performed using a commercial tool and the necessary outcomes are obtained via an eight noded solid element (Solid 185-element) from the library of ANSYS. The structural analysis input has been incurred through ANSYS parametric design language (APDL) code. The normal and shear stress distributions along different layers of the joint structure have been evaluated as the final outcomes. Based on the stress distributions, failure location in the composite joint structure has been identified by using the Tsai-Wu stress failure criterion. It has been found that the failure index is maximum at the interface between flange and web part of the joint (top layer) which indicates the probable location of failure initiation. This kind of failures are considered as adhesion failure and the failure propagation is governed by strain energy release rate (SERR) of fracture mechanics. The different adhesion failure lengths are also considered at the failure location to calculate the SERR values i.e. mode I fracture (opening), mode II fracture (sliding) and mode III fracture (tearing) along the failure front. Also, virtual crack closure technique (VCCT) principle of fracture mechanics steps is used to calculate the above said SERRs. It is found that the mode I SERR is more dominating compared to other two modes of failure for the joint considered. Finally, the influences of various parametric (geometrical and material) effect on SERR of the joint structure are evaluated and discussed in details.

Essential oils and their pharmacotherapeutics applications in human diseases

Panda Sneha,Sahoo Soumya,Tripathy Kabita,Singh Yengkhom Disco,Sarma Mrinal Kumar,Babu Punuri Jayasekhar,Singh Mayanglambam Chandrakumar 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.1

Essential oils (EOs) are natural products obtained from different parts of a plant, such as flower, leaves, stems, fruits, seeds, roots, barks, or resin. It represents an important part of traditional pharmacopeia practices in healing of human ailments. It is used as raw materials in cosmetics, spices, foods, perfumes, and in treatment of several health disorders. There are several methods for extracting EOs from plants. They are the methods like hydro-distillation, steam distillation, hydro diffusion and cold pressing to name a few. The use of EOs as antimicrobial and pharmaceutical agents for curing various diseases has gained a considerable attraction of researchers in recent times. The complex mixture of EOs and their constituents have been reported to inhibit human pathogens, insects, and another harmful organism. The current review focusses on the chemical bioactive components of EOs, methods of extraction, chemical constituent, different plants as source of extraction and its application towards the treatment of various diseases in our day to day life, in vivo validation of essential oil, nanoformula- tion of essential oils

Effect of Butyric Acid on Performance, Gastrointestinal Tract Health and Carcass Characteristics in Broiler Chickens

Panda, A.K.,Rama Rao, S.V.,Raju, M.V.L.N.,Shyam Sunder, G. Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.7

An experiment was conducted to study the effect of graded levels of butyric acid (butyrate) on performance, gastrointestinal tract health and carcass characteristics in young broiler chickens. Control starter (0-3 wk) and finisher (4-5 wk) diets were formulated to contain 2,900 kcal ME/kg and 22% CP, and 3,000 kcal ME/kg and 20% CP, respectively. Subsequently, four other experimental diets were formulated to contain 0.05% antibiotic (furazolidone) or 0.2, 0.4 and 0.6% butyric acid. Each diet was fed at random to 8 replicates of 6 chicks each throughout the experimental period (0-5 wk). The results showed that 0.4% butyrate in the diet was similar to antibiotic in maintaining body weight gain and reducing E. coli numbers but superior for feed conversion ratio. No added advantage on these parameters was obtained by enhancing the concentration of butyrate from 0.4 to 0.6% in the diet. Feed intake and mortality were not influenced by the dietary treatments. A reduction in pH of the upper GI tract (crop, proventiculus and gizzard) was observed by inclusion of butyrate in the diets of broilers compared to either control or antibiotic-fed group. Butyrate at 0.4% was more effective in reducing the pH than 0.2% butyrate. Within the lower GI tract, 0.4 and 0.6% butyrate was effective in lowering pH in the duodenum, but no effect was found in either the jejunum or ileum. The villus length and crypt depth in the duodenum increased significantly in all the butyrate treated diets irrespective of the level tested. Carcass yield was higher and abdominal fat content was lower significantly in all the butyrate treatment groups compared to the control or antibiotic group. From these findings, it is concluded that 0.4% butyric acid supplementation maintained performance, intestinal tract health, and villi development and carcass quality in broiler chickens.

Bio-inspired fluorescence probe for ultra level detection of aliphatic amines

Panda, Atanu,Venkateswarlu, Sada,Reddy, Ankireddy Seshadri,Yoon, Minyoung Elsevier 2018 Dyes and pigments Vol.156 No.-

<P><B>Abstract</B></P> <P>The detection of trace amounts of amines is essential to mitigate toxicity and health risks. Various chemical probes have been reported for the detection of amines, which are expensive, difficult to handle, and toxic. In this study, we have developed a bio-inspired fluorescent probe for ultra-level detection of amines in liquid solution. Diatoms, which are silicified algae were used strategically for the detection of aliphatic amines. The presence of an electron-deficient moiety in diatoms improves the ability of diatoms to detect electron-rich organic amines. When an organic amine binds to the pyrolyzed diatom, enhanced photoluminescence and a color change under UV irradiation were observed. Interestingly, fluorescence analysis revealed that the diatoms can selectively detect aliphatic amines with sensitivity up to the pM level, even in the presence of other volatile organic compounds. Among the given analytes, only the electron-rich aliphatic amines significantly enhanced the fluorescence intensity. In contrast, aromatic amines and other organic solvents did not exhibit a fluorescence signal for detection. In particular, ethylenediamine (EDA) contributes the most apparent enhancement effect, with a detection limit of 116 pM. Therefore, diatoms were proved it potential as a tool for monitoring toxic organic molecules.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Developed a bio-inspired 'turn-on' fluorescence probe, a pyrolyzed diatom, for the detection of aliphatic amines in the liquid phase. </LI> <LI> The diatom has excellent selectivity towards aliphatic amines better than aromatic amines. </LI> <LI> The sensitivity of the probe is achieved up to pM level of aliphatic amines. </LI> <LI> Facile identification of the sensing properties by visual color analysis. </LI> <LI> This low-cost material could be an attractive fluorescent probe for the detection of electron-rich molecules. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Turn-on diatom fluorescence towards aliphatic amine binding.</P> <P>[DISPLAY OMISSION]</P>

Synergistic interactions of Aegle marmelos leaf, Emblica officinalis fruit and Ocimum sanctum leaf extracts in the regulation of hyperthyroidism and / or hyperglycaemia

Panda, Sunanda,Kar, Anand Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.1

The effects of Aegle marmelos (Rutaceae) leaf, Emblica officinalis (Euphorbiaceae) fruit and Ocimum sanctum. (Labiateae) leaf extracts were studied in L-thyroxine (0.5 mg/kg) induced hyperthyroidic mice. Separately combined effects of these three plant extracts and of a commonly used antithyroidic drug, Propyl thiouracil (PTU) were investigated for comparison. Serum concentration of thyroxine $(T_4)$, triiodothyronine $(T_3)$, glucose and the activity of hepatic Glucose 6-Phosphatase (G-6-Pase) were considered as main parameters. Hepatic lipid peroxidation (LPO), superoxide dismutase (SOD) and Catalase (CAT) activities were also studied to reveal the toxic effect of the plant extracts, if any. While exogenous $T_4$ enhanced serum concentration of $T_4$, $T_3$, glucose and the activity of hepatic G-6-Pase, a simultaneous administration of either A. marmelos leaf (1.0 mg/kg), E. officinalis fruit( 30 mg/kg) and O. sanctum leaf (50 mg/kg) extracts, to hyperthyroidic animals decreased all these parameters. However, the effects were more pronounced, as nearly normal thyroid function and serum glucose concentration were exhibited when all three plant extracts were administered together. A decrease in LPO and a concomitant increase in SOD and the CAT activities indicated the safe and antiperoxidative nature of the plant extracts, administered either alone or in combination. Our findings reveal that the three test plant materials exhibit synergistic effects without any hepatotoxicity, suggesting their potential use in the amelioration of hyperthyroidism and/ or hyperglycaemia.

A Benzodipyrrole-Derived Sapphyrin

Panda, Pradeepta K,Kang, Young-Jin,Lee, Chang-Hee WILEY-VCH Verlag 2005 Angewandte Chemie. international edition Vol.44 No.26

<B>Graphic Abstract</B> <P>Within the framework: The fused benzodipyrrole unit within the sapphyrin 1 has a significant influence on its structure as compared to those of usual sapphyrins. The fused benzene ring partly inhibits distortion of the macrocycle about the dipyrrole unit (see structure of 1⋅2 H<SUP>+</SUP> 2 (p-CH<SUB>3</SUB>C<SUB>6</SUB>H<SUB>4</SUB>SO<SUB>3</SUB><SUP>−</SUP>); C gray, N blue, O red, S yellow) and contributes to the significant red-shift of Q-bands. <img src='wiley_img/14337851-2005-44-26-ANIE200500944-content.gif' alt='wiley_img/14337851-2005-44-26-ANIE200500944-content'> </P>

Bilateral congenital alveolar synechiae-a rare cause of trismus

Panda, Smriti,Sikka, Kapil,Punj, Jyotsna,Sharma, Suresh C. Korean Association of Maxillofacial Plastic and Re 2016 Maxillofacial Plastic Reconstructive Surgery Vol.38 No.-

Congenital alveolar synechiae is a rare anomaly mostly presenting in association with cleft palate. Owing to reduced mouth opening, feeding difficulties, and compromised airway in extreme cases along with presentation in early neonatal period, these patients present unique challenges to the surgeon as well as the anesthetist. Here, we discuss the surgical and anesthetic management of this entity in a 12-month-old female child.

Influence of Supplemental Vitamin D₃ on Production Performance of Aged White Leghorn Layer Breeders and Their Progeny

Panda, A.K.,Rao, S.V. Rama,Raju, M.V.L.N.,Niranjan, M.,Reddy, B.L.N. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.11

An experiment was conducted to elucidate the effect of graded levels of vitamin $D_3$ in White Leghorn (WL) layer breeders on egg production, shell quality, hatchability of eggs and juvenile performance of offspring during their late laying period (72-88 wk). White Leghorn breeder females were randomly divided into 5 groups of 50 each and were housed in individual California cages in an open-side housing system. Considering birds in five cages as a replicate, 10 such replicates were randomly allotted to each treatment. A basal diet was formulated containing all the nutrients as recommended for WL layers except vitamin $D_3$, which served as control. Another, four diets were formulated by supplementing graded levels of feed grade crystalline cholecalciferol to the basal diet that contained 300, 600, 1,200 and 2,400 ICU of vitamin $D_3$ per kg. Each diet was offered ad libitum to one of the above five treatment groups. The egg production, egg weight, daily feed consumption and the feed intake per dozen eggs or kg egg mass of the birds fed diet without any supplemental vitamin $D_3$ was comparable with those of supplemental groups. Similarly, the level of vitamin in the diet did not have any effect on any of the above parameters. However, the specific gravity of eggs laid by the birds fed the diet without supplemental vitamin $D_3$ was comparable with either 600 or 2,400 ICU supplemental groups but significantly higher when compared to the 300 and 1,200 ICU groups. The egg -shell breaking strength was significantly lowered in the 600 ICU supplemental groups as compared to the strength of other dietary groups. The Haugh unit, egg shell weight, shell thickness, tibia breaking strength, bone ash and calcium content were not influenced by vitamin $D_3$ concentration in the diet. Serum Ca concentration was influenced by vitamin $D_3$ level in the diet. The serum Ca concentration of birds fed either control or the vitamin supplemented diet up to 1200 ICU/kg diet was comparable. However, increasing the concentration of vitamin $D_3$ to 2,400 ICU/kg diet significantly enhanced the concentration of Ca in the serum, which was significantly higher compared to other dietary groups. The serum concentration of P and protein, however, was not influenced by level of vitamin $D_3$ in the diet. Neither fertility nor hatchability was influenced by vitamin $D_3$ concentration in the diet. Feeding a vitamin $D_3$ deficient diet or supplementation of vitamin to hens did not have any influence on their progeny chicks. It can be concluded that dietary supplementation of vitamin $D_3$ may not be essential for optimum production, shell quality, hatchability, and juvenile performance of WL breeders during 72 to 88 weeks of age.

Perception and Practices of Physicians in Addressing the Smokeless Tobacco Epidemic: Findings from Two States in India

Panda, Rajmohan,Persai, Divya,Mathur, Manu,Sarkar, Bidyut Kanti Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: Smokeless tobacco use in South Asia is believed to be a significant contributor to morbidity and mortality. In India, only a few studies involving health educational intervention by health care providers have demonstrated reduction in smokeless tobacco usage. In the present study we assessed the cessation efforts towards smokeless tobacco by physicians in two high tobacco prevalence states of India. The study also identified opportunities and barriers for integration of tobacco cessation services in routine practices of physicians. Materials and Methods: This mixed method study involved qualitative (phase I) and quantitative research study (phase II). In phase I, 59 in-depth interviews with physicians were conducted. In phase II, a quantitative study conducted among 238 physicians. An inductive approach was followed to analyze qualitative data using ATLAS. Ti software. The Chi-square test was employed to test the association between different variables of interest using SPSS version 17. Results: The majority of physicians related only respiratory problems and cancer with smokeless tobacco. Other major health effects like cardio-vascular problems, oral diseases, and effects on reproductive and neonatal health were recognized only by a few physicians. The age-group of 10-19 years was identified as most vulnerable to smokeless tobacco use. Less than one-third of physicians reported recording smokeless tobacco history of all patients. Findings indicated that less than half of physicians provided information on harmful health effects of smokeless tobacco with regard to specific diseases. Conclusions: The study revealed a low level of knowledge of physicians about harmful effects of tobacco and their suboptimal engagement in tobacco control practices. The study indicates the need of capacity building initiatives to equip physicians with skills in tobacco cessation.