http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Pan Kuan-Cheng (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
DEN1 deneddylates non-cullin proteins in vivo.
Chan, Yaru,Yoon, Jeongsook,Wu, June-Tai,Kim, Hyung-Jun,Pan, Kuan-Ting,Yim, Jeongbin,Chien, Cheng-Ting Cambridge University Press 2008 Journal of cell science Vol.121 No.19
<P>The ubiquitin-like protein Nedd8/Rub1 covalently modifies and activates cullin ubiquitin ligases. However, the repertoire of Nedd8-modified proteins and the regulation of protein neddylation status are not clear. The cysteine protease DEN1/NEDP1 specifically processes the Nedd8 precursor and has been suggested to deconjugate Nedd8 from cullin proteins. By characterizing the Drosophila DEN1 protein and DEN1 null (DEN1(null)) mutants, we provide in vitro and in vivo evidence that DEN1, in addition to processing Nedd8, deneddylates many cellular proteins. Although purified DEN1 protein efficiently deneddylates the Nedd8-conjugated cullin proteins Cul1 and Cul3, neddylated Cul1 and Cul3 protein levels are not enhanced in DEN1(null). Strikingly, many cellular proteins are highly neddylated in DEN1 mutants and are deneddylated by purified DEN1 protein. DEN1 deneddylation activity is distinct from that of the cullin-deneddylating CSN. Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 is crucial for animal viability.</P>
-
Lin Hsin-Hung,Wu Sheng-Ju,Liu Tsung-Lung,Pan Kuan-Cheng 한국항공우주학회 2021 International Journal of Aeronautical and Space Sc Vol.22 No.1
Compared with land-based helicopters, ship-based helicopters are required to land in a more challenging working environment as the airwakes generated by the wind field flowing through the superstructure of the ship changes the wind field structure. This complicates the wind field structure and affects the safety of flight control. The flight safety of the helicopter pilot can be significantly improved with prior understanding of the relevant information in the ship-based helicopter operating limits (SHOL) diagram. In previous studies, the SHOL diagram of ship-based helicopters has been obtained using numerical simulations in conjunction with a flight simulator. However, the flight simulator equipment is expensive and difficult to maintain. This study references the aforementioned studies by initially employing a numerical simulation method to obtain the flow field information of the interaction between the airwakes of the ship’s superstructure and the downwash flow of the helicopter. Then, the flight simulator is replaced by computational intelligence methods involving artificial intelligence. This significantly reduces the research cost for envelope construction. This study integrates design of experiments (DOE) and computational intelligence techniques (soft computing) to establish a recommended range for the SHOL diagram of ship-based helicopters. This study utilizes the DOE and computational intelligence techniques to construct the SHOL diagram of ship-based helicopters, provide suggestions, and serve as a reference for helicopter pilots and engineering designers to improve the safety during flight.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
