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RISS 인기검색어
- 검색키워드
- 저자 : Pallab K. Haldar (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Anti-inflammatory activity and antioxidant role of Zanthoxylum nitidum bark
Sanjib Bhattacharya,Pallab K. Haldar,K. Zaman 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
In the present study, the methanol extract of stem bark of Zanthoxylum nitidum (ZNME) was evaluated for its anti-inflammatory activity in acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic model (cotton pellet induced granuloma) along with reference drug indomethacin (10 mg/kg body wt. p.o.). The ZNME (75 and 150 mg/kg body wt. p.o.) exhibited significant activity (p<0.001) against all phlogistic agents employed in a dose dependent manner. In chronic model also the ZNME caused a significant (p<0.001) and dose dependent inhibition of granuloma formation. The ZNME was evaluated for its antioxidant properties by 1,1- diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay and in vitro lipid peroxidation induced by the Fe^(2+)-ascorbate system in rat liver homogenate. In DPPH radical scavenging assay, the ZNME demonstrated marked and dose dependent free radical scavenging effect and the mean inhibitory concentration (IC_(50)) of the ZNME was found to be 77.8 μg/ml,while the ascorbic acid (reference) exhibited 43.7 μg/ml. The ZNME effectively inhibited the lipid peroxidation in a dose related manner showing the IC_(50) value of 297.9 μg/ml,whereas the catechin (reference) showed 46.64 μg/ml. These findings reveal that the ZNME possessed promising acute and chronic anti-inflammatory and in vitro antioxidant actions in the tested models.
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Anti-inflammatory activity and antioxidant role of $Zanthoxylum$ $nitidum$ bark
Bhattacharya, Sanjib,Haldar, Pallab K.,Zaman, Md.K. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
In the present study, the methanol extract of stem bark of $Zanthoxylum$ $nitidum$ (ZNME) was evaluated for its anti-inflammatory activity in acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic model (cotton pellet induced granuloma) along with reference drug indomethacin (10 mg/kg body wt. p.o.). The ZNME (75 and 150 mg/kg body wt. p.o.) exhibited significant activity ($p$ <0.001) against all phlogistic agents employed in a dose dependent manner. In chronic model also the ZNME caused a significant ($p$ <0.001) and dose dependent inhibition of granuloma formation. The ZNME was evaluated for its antioxidant properties by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay and $in$ $vitro$ lipid peroxidation induced by the $Fe^{2+}$-ascorbate system in rat liver homogenate. In DPPH radical scavenging assay, the ZNME demonstrated marked and dose dependent free radical scavenging effect and the mean inhibitory concentration ($IC_{50}$) of the ZNME was found to be 77.8 ${\mu}g$/ml, while the ascorbic acid (reference) exhibited 43.7 ${\mu}g$/ml. The ZNME effectively inhibited the lipid peroxidation in a dose related manner showing the $IC_{50}$ value of 297.9 ${\mu}g$/ml, whereas the catechin (reference) showed 46.64 ${\mu}g$/ml. These findings reveal that the ZNME possessed promising acute and chronic anti-inflammatory and $in$ $vitro$ antioxidant actions in the tested models.
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Neuropharmacological assessment of $Curcuma$ $caesia$ rhizome in experimental animal models
Karmakar, Indrajit,Saha, Pathik,Sarkar, Nilanjan,Bhattacharya, Sanjib,Haldar, Pallab K. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
$Curcuma$ $caesia$ Roxb. (Zingiberaceae), called black turmeric in English, is a perennial herb found throughout the Himalayan region, North-East and Central India. The plant has been traditionally used in India for several medicinal purposes. The present study was carried out to evaluate the methanol extract of $C.$ $caesia$ rhizome (MECC) for some neuropharmacological activities in experimental animal models. MECC (at 50 and 100 mg/kg body weight) was evaluated for analgesic activity by acetic acid-induced writhing and tail flick tests. Locomotor activity was measured by means of an actophotometer. Anticonvulsant property was assessed against pentylenetetrazol-induced convulsion in mice and muscle relaxant effect was evaluated by using rota-rod apparatus. The results of the present study revealed remarkable analgesic, locomotor depressant, anticonvulsant and muscle relaxant effects of $C.$ $caesia$ rhizome, demonstrating depressant action on the central nervous system. The outcome of present study can validate certain traditional uses of $C.$ $caesia$ rhizome in India.
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Neuropharmacological assessment of Curcuma caesia rhizome in experimental animal models
Indrajit Karmakar,Pathik Saha,Nilanjan Sarkar,Sanjib Bhattacharya,Pallab K. Haldar 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
Curcuma caesia Roxb. (Zingiberaceae), called black turmeric in English, is a perennial herb found throughout the Himalayan region, North-East and Central India. The plant has been traditionally used in India for several medicinal purposes. The present study was carried out to evaluate the methanol extract of C. caesia rhizome (MECC)for some neuropharmacological activities in experimental animal models. MECC (at 50 and 100 mg/kg body weight)was evaluated for analgesic activity by acetic acid-induced writhing and tail flick tests. Locomotor activity was measured by means of an actophotometer. Anticonvulsant property was assessed against pentylenetetrazol-induced convulsion in mice and muscle relaxant effect was evaluated by using rota-rod apparatus. The results of the present study revealed remarkable analgesic, locomotor depressant, anticonvulsant and muscle relaxant effects of C. caesia rhizome,demonstrating depressant action on the central nervous system. The outcome of present study can validate certain traditional uses of C. caesia rhizome in India.
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