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( Palanisamy Ravichandiran ),유동진 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
A new naphthoquinone-based chemosensor 2HPN for the selective detection of Fe<sup>2+</sup> ion has been developed. The sensing property of the chemosensor 2HPN was evaluated in aqueous acetonitrile (CH<sub>3</sub>CN) medium by a fluorescence emission method. The metal binding studies of ligand 2HPN showed selective “turn-on” fluorescence responses for Fe<sup>2+</sup> ion (Ka = 1.0 × 106 M<sup>-1</sup>). The detection limit of the ligand 2HPN to Fe<sup>2+</sup> was calculated to be 0.272 μM, which is lower than the WHO recommendation in drinking water. Significantly, the obtained chemosensor 2HPN it the ability to sense Fe<sup>2+</sup> via naked-eye detection over various metal ions. The chemosensor operated through the intramolecular charge transfer (ICT) mechanism that was further supported by FT-IR analysis, NMR titrations, and DFT calculations. The efficiency of the chemosensor 2HPN as a biomarker for Fe<sup>2+</sup> was successfully demonstrated by bio-imaging of human cancer cells and zebrafish.
Ravichandiran, Palanisamy,Subramaniyan, Sivakumar Allur,Bella, Antony Paulraj,Johnson, Princy Merlin,Kim, Ae Rhan,Shim, Kwan Seob,Yoo, Dong Jin American Chemical Society 2019 ANALYTICAL CHEMISTRY - Vol.91 No.15
<P>A phenoxazine-based fluorescence chemosensor <B>4PB</B> [(4-(<I>tert</I>-butyl)-<I>N</I>-(4-((4-((5-oxo-5<I>H</I>-benzo[<I>a</I>]phenoxazin-6-yl)amino)phenyl)sulfonyl)phenyl)benzamide)] was designed and synthesized by a simple synthetic methods. The <B>4PB</B> fluorescence chemosensor selectively detects Ba<SUP>2+</SUP> in the existence of other alkaline metal ions. In addition, <B>4PB</B> showed high selectivity and sensitivity for Ba<SUP>2+</SUP> detection. The detection limit of <B>4PB</B> was 0.282 μM and the binding constant was 1.0 × 10<SUP>6</SUP> M<SUP>-1</SUP> in CH<SUB>3</SUB>CN/H<SUB>2</SUB>O (97.5:2.5 v/v, HEPES = 1.25 mM, pH 7.3) medium. This chemosensor functioned through the intramolecular charge transfer (ICT) mechanism, which was further confirmed by DFT studies. Live cell imaging in MCF-7 cells confirmed the cell permeability of <B>4PB</B> and its capability for specific detection of Ba<SUP>2+</SUP> in living cells.</P> [FIG OMISSION]</BR>