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- 저자 : P. R. Oldfield (검색결과 1 건)
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The Potency of Immunomodulatory Herbs May Be Primarily Dependent upon Macrophage Activation
P. R. Oldfield,S. N. Groom,T. Johns 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Standardized extracts of Echinacea, cat’s claw, and saw palmetto were each evaluated for ability to activatemacrophage and natural killer cells, in vitro, using two independent measures of activation for each immune cell population.A standard series of exposure concentrations were tested for each herbal extract in a panel of four assays that evaluatedmacrophage phagocytosis, macrophage synthesis of interleukin-12, natural killer (NK) cell cytocidal activity (synthesis ofgranzyme B), and NK cell synthesis of interferon-.. Macrophage phagocytosis was stimulated by all three herbs tested: sawpalmetto (up to 2.3-fold, P. .05), Echinacea P. .01), and cat’s claw (up to 4.7-fold, P. .01). Addition-ally, NK cell synthesis of interferon-. was stimulated by saw palmetto (up to 6.3-fold, P. .01) and Echinacea(up to 8.1-fold, P. .01) but not by exposure to cat’s claw. None of the three herbs stimulated macrophage synthesis of interleukin-12or NK cell synthesis of granzyme B. Comparison of the in vitrodata with our earlier observations that cat’s claw and Echi-naceagests macrophage activation is the primary means by which these herbs modulate the immune system. Thus, macrophage ac-tivation (phagocytosis) may provide a potentially higher throughput method to identify herbal extracts with in vivostimulatoryeffects.
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