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- 저자 : P. Malliga (검색결과 1 건)
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Analytical approach for optimization design of MEMS based microneedles in drug delivery system
N. Raja Rajeswari,P. Malliga 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.8
Microneedles have been recently given much attention as a novel way for transdermal drug delivery. In this paper, the mechanics ofmicroneedle insertion into soft tissue and also the changes in the forces and moments of the microneedle is to be presented. A non-lineardisplacement of the microneedle insertion into the soft tissue is expressed as a quadratic polynomial function and solved using Galerkintechnique. The geometrical behavior of the microneedle tip is to be considered in the analytical model. The microneedle insertion isclassified into two phases namely, pre-puncture and post-puncture. An analytical model of microneedle stiffness coefficient and effect ofinterfacial contact force in frictionless condition are derived using Love’s thin rod theory. The interfacial contact stresses at the interfacebetween the microneedle and soft tissue are obtained from the contact forces using the Hertzian theory. Statistical analysis based on theanalytical model was done for studying various effects of process variables on the dependent variables. The statistical analysis was doneby Analysis of variance (ANOVA). The graphical analysis of the analytical model are presented using MATLAB. The analytical modelhelps to improve the microneedle design by minimizing the pain of insertion and increasing the mechanical strength.
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