http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Oluwasanmi O. Aina (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Tolulope O. Ajala,Mbang N. Femi-Oyewo,Oluwatoyin A. Odeku,Oluwasanmi O. Aina,Adebowale B. Saba,Olayinka O. Oridupa 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.2
The ethanol extract of Phyllanthus amarus (Schum and Thonn), a plant of ethnomedicinal importance, was formulated into herbal cream and ointment and evaluated using physicochemical, safety and antimicrobial properties. The extract was obtained by maceration and the antimicrobial properties tested on clinically isolated pathogenic bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) and dermatophytes (Trichophyton rubrum and Candida albicans) using established methods. Cream and ointment formulations containing 1–10 % w/w extract was prepared and 4 % w/w humectant (glycerin) was incorporated into the cream while 5 % w/w surfactant (cetomacrogol 1000) was incorporated to the ointment. The results showed that the pH of the formulations was acidic and the viscosity ranged from 1250 to 4950 cP for ointments and 570–1233 cP for creams. The presence of humectant and surfactant significantly (p\0.05) reduced the viscosities of the formulations. The results of dermal irritation showed negligible irritation index while subchronic toxicity tests showed that the formulations did not cause any visible lesions in the skin of the animals after application for twenty-one days. The in vitro antimicrobial properties of formulations were concentration-dependent with the creams showing higher activity. Furthermore, the in vivo activity of the cream on S. aureus showed increased antibacterial activity with increase in extract concentration and humectant presence. The herbal cream and ointment of Phyllanthus amarus extract had acceptable physicochemical and safety profiles with significant (p\0.05) in vitro and in vivo antimicrobial activity. Thus, the formulations could be useful in the treatment of skin infections instead of using the extract for bathing and rubbing.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
