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Santaclara, Jara G.,Olivos-Suarez, Alma I.,Gonzalez-Nelson, Adrian,Osadchii, Dmitrii,Nasalevich, Maxim A.,van der Veen, Monique A.,Kapteijn, Freek,Sheveleva, Alena M.,Veber, Sergey L.,Fedin, Matvey V. American Chemical Society 2017 Chemistry of materials Vol.29 No.21
<P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2017/cmatex.2017.29.issue-21/acs.chemmater.7b03320/production/images/medium/cm-2017-03320d_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm7b03320'>ACS Electronic Supporting Info</A></P>
Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes
Arhel, Nathalie,Genovesio, Auguste,Kim, Kyeong-Ae,Miko, Sarah,Perret, Emmanuelle,Olivo-Marin, Jean-Christophe,Shorte, Spencer,Charneau, Pierre Nature Publishing Group 2006 Nature methods Vol.3 No.10
Emerging real-time techniques for imaging viral infections provide powerful tools for understanding the dynamics of virus-host cell interactions. Here we labeled human immunodeficiency virus-1 (HIV-1) integrase with a small tetracysteine tag, which preserved the virus' infectivity while allowing it to be labeled with the bis-arsenical fluorescein derivative FlAsH. This labeling allowed us to image both intracytoplasmic and intranuclear HIV-1 complexes in three dimensions over time (4D) in human cells and enabled us to analyze HIV-1 kinetics by automated 4D quantitative particle tracking. In the cytoplasm, HIV-1 complexes underwent directed movements toward the nuclear compartment, kinetically characteristic of both microtubule- and actin-dependent transport. The complexes then adopted smaller movements in a very confined volume once associated with the nuclear membrane and more diffuse movements once inside the nucleus. This work contributes new insight into the various movements of HIV-1 complexes within infected cells and provides a useful tool for the study of virus-host cell interactions during infection.
Ultrasensitive Near‐Infrared Raman Reporters for SERS‐Based In Vivo Cancer Detection
Samanta, Animesh,Maiti, Kaustabh Kumar,Soh, Kiat‐,Seng,Liao, Xiaojun,Vendrell, Marc,Dinish, U. S.,Yun, Seong‐,Wook,Bhuvaneswari, Ramaswamy,Kim, Hyori,Rautela, Shashi,Chung, Junho,Olivo, Ma WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.27
<P><B>Zuverlässige Berichterstattung</B>: Das Screening einer 80‐teiligen Tricarbocyanin‐Bibliothek lieferte CyNAMLA‐381 als Nahinfrarot‐SERS‐Reporter mit guter Signalstabilität und höherer Empfindlichkeit als der Standard (SERS=oberflächenverstärkte Raman‐Spektroskopie). Durch Verkapselung von CyNAMLA‐381 an der Oberfläche von Gold‐Nanopartikeln und Konjugation mit Antikörpern wurden SERS‐Nanomarker mit ausgezeichneter Empfindlichkeit, Stabilität und Tumorspezifität in Xenograft‐Modellen erhalten (siehe Bild).</P>