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Sohn Hyung-Ok,Hyun Hak-Chul,Shin Han-Jae,Han Jung-Ho,Park Chul-Hoon,Moon Ja-Young,Lim Heung-Bin,Kim Yong-Sun,Lee Dong-Wook The Korean Society of Tobacco Science 2005 한국연초학회지 Vol.27 No.2
Cigarette smoking has been known to have a few beneficial effects on some neuronal diseases such as Alzheimer's disease(AD), Parkinson's disease(PD) and prion disease by scrapie agent shows many similar properties with AD. In this respect, we investigated what biological effects are exerted by cigarette smoke exposure(CSE) in the brain of mouse infected by 87V scrapie. The scrapie agent was inoculated through stereotaxic microinjection of the homogenates of the scrapie agent infected brain into the intracerebral system in the 1M mice. The inoculation into mice typically exhibits neurochemical, physiological and histopathological characteristics of prion disease: loss of neurotransmitters and induction of astrocytosis and vacuolation in brain as well as reduction of spatial movement and loss of body weight. CSE led to alleviated the loss of body weight and also improved spatial movement of the infected mice. Most interestingly, CSE attenuated astrocytosis and vacuolation caused by scrapie infection in the brain. In addition, decreased levels of dopamine in striatal and hypothalamic regions as well as serotonin level in hippocampus caused by scrapie infection were also attenuated by exposure to cigarette smoke. These findings suggest that cigarette smoke, by its inhibition of astrocytosis and vacuolation followed by its restoration of levels of some neurotransmitters, may partly contribute to suppression in the progress of neurodegeneration caused by scrapie infection.
( Jae Hyun Park ),( Kyeong Ok Kim ),( Se Hoon Sohn ),( Ho Chan Lee ),( Yo Han Jeong ),( Sung Bum Kim ),( Kook Hyun Kim ),( Si Hyung Lee ),( Byung Ik Jang ),( Tae Nyeun Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: There were several studies about the predictors of compliance to IBD therapy. However, there were few studies about the predictors of follow up loss in IBD patients. Our aims were to find the predictors of follow up loss of visiting clinics in IBD patients. Methods: The medical record of 224 patients with IBD who were followed up between January 2010 and December 2013 were reviewed retrospectively. Follow up loss was defined that patients didn`t visit clinics at least 6 months. Results: Among 224 patients with IBD, there were 94 patients with Crohn`s disease and 130 patients with ulcerative colitis. Mean follow up duration was 58.51 months. The follow up loss was noted in 32.1% of patients. The follow up loss rate in patients with CD and UC were 28.7% and 34.6 % respectively. Age, gender and disease severity index at the last visit before loss could not show any difference according to the status of follow up. Mean follow up loss duration was 17.72 months. All of the patients who followed up loss revisited clinics because of mainly disease aggravation. Lower Education status and C reactive protein also increased the risk for follow up loss by 2.13 and 1.81 times, respectively. By multivariate analysis, risk factors of follow up loss were C reactive protein level below 1.2mg/dL and lower educational status. Conclusions: Among 224 IBD patients, 32.1% patients followed up loss at least once. Lower educational status and low C reactive protein level increased the rate of follow up loss in IBD patients. Clinician takes an effort to help the patients with lower educational status or low C reactive protein level understand the disease and disease course to prevent follow up loss.
이재형 ( Jae Hyung Lee ),김일옥 ( Il Ok Kim ),이희경 ( Hee Kyung Lee ),민경환 ( Kyueng Whan Min ),김상헌 ( Sang Heon Kim ),김태형 ( Tae Hyung Kim ),손장원 ( Jang Won Sohn ),윤호주 ( Ho Joo Yoon ),신동호 ( Dong Ho Shin ),박찬금 ( C 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.4
A thymoma commonly occurs in the superior mediastinum or the upper part of the anterior mediastinum but can be located in other places in rare cases. Cystic degeneration in a thymoma is a relatively common but focal event. In rare cases, the process proceeds to the extent that most if not all of the lesion becomes cystic. We report a case of a patient with a paracardial cystic thymoma in the lower aspect of the anterior mediastinum. A 49-year-old woman was referred to our hospital because of a mass discovered incidentally on a chest X-ray. She showed no symptoms or signs. Contrast-enhanced chest CT scan revealed a 5x5cm sized, well-marginated, right paracardial cystic mass with a curvilinear and oval enhancing solid portion. A Surgical resection was performed. The mass was discontinuous with normal thymic tissue. Microscopy revealed a type B1 thymoma with prominent foci of medullary differentiation according to the WHO classification. There was no capsular or local invasion. The postoperative course was uneventful and the patient was discharged in good health. (Tuberc Respir Dis 2007; 62: 331-335)