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1
Falls and Their Associated Risks in Parkinson’s Disease Patients in Nigeria

Temitope Hannah Farombi,Mayowa O Owolabi,Adesola Ogunniyi 대한파킨슨병및이상운동질환학회 2016 Journal Of Movement Disorders Vol.9 No.3
- 복사/대출신청
Objective Falls are a devastating consequence of Parkinson’s disease (PD) and are due to motor imbalance. However, the frequency of falls and their risk factors among Nigerians with PD is not known despite the significant increase in PD cases in the country. To assess fall risk factors and frequency in Nigerian PD patients. Methods Using an analytical design to compare falling versus non-falling patients, 81 PD patients were assessed for clinical factors, frequency of falls, and candidate risk factors for falls according to the Tinetti Balance and Gait, Unified Parkinson’s Disease Rating Scale subsection 1, and Timed Up and Go Tests. Descriptive, bivariate, and multivariate analyses were performed at the 95% confidence level. Results The mean age of participants was 65.6 ± 9.7 years. Falls were about three times (p < 0.001) more common in PD patients. Of the falling patients, 67.7% sustained injuries, 67.7% had recurrent falls and 44.9% admitted to having a fear of falling. The independent statistical predictors of fall were fear of falling [odds ratio (OR): 3.86], disease severity (OR: 1.09) and disease duration (OR: 1.01). Conclusion The frequency of falls in PD patients was significantly higher when compared with the healthy adult population, and the modifiable predictor was fear of falling with a potential to significantly reduce falls when strategically addressed
2
Zeolitic Imidazolate Frameworks (ZIFs) for aqueous phase adsorption – A review

Joshua O. Ighalo,Selvasembian Rangabhashiyam,Comfort Abidemi Adeyanju,Samuel Ogunniyi,Adewale George Adeniyi,Chinenye Adaobi Igwegbe 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
Zeolitic Imidazolate Frameworks (ZIFs) represents a subclass of the metal-organic frameworks (MOFs),composed mainly of tetrahedrally coordinated transition metals. The aim of this review was to evaluatethe experimental findings on the adsorption of different aqueous pollutants using ZIFs. ZIF adsorptionmechanism was electrostatic attraction, p-p interaction and complexation though others were observedbased on pollutant type and nature of the solution chemistry. Thermodynamic modelling revealed thatZIF adsorption is usually spontaneous and endothermic. The adsorbent can be re-used for 3–4 cycles with>70% retention of uptake performance. NaOH, methanol and ethanol were observed to be the more suitableand effective eluents for desorption of adsorbate from ZIF. The nature of the adsorbate and the typeof uptake mechanism are the two key considerations in competitive adsorption systems. When theuptake mechanism of the main adsorbate species is different from that of the competing species, thenthe adsorption process is unaffected. Investigations on adsorbent disposal, targeted modification, functionalisation,emerging contaminants removal, column adsorption studies and molecular modellingwould be needed to fill in gaps in knowledge in ZIF related studies.
3
Modulation of Adherence, Invasion, and Tumor Necrosis Factor Alpha Secretion during the Early Stages of Infection by Streptococcus pneumoniae ClpL

Tu, Le Nhat,Jeong, Hye-Yoon,Kwon, Hyog-Young,Ogunniyi, Abiodun D.,Paton, James C.,Pyo, Suhk-Neung,Rhee, Dong-Kwon American Society for Microbiology 2007 Infection and immunity Vol.75 No.6
- 원문보기
ABSTRACTHeat shock proteins (HSPs) play a pivotal role as chaperones in the folding of native and denatured proteins and can help pathogens penetrate host defenses. However, the underlying mechanism(s) of modulation of virulence by HSPs has not been fully determined. In this study, the role of the chaperone ClpL in the pathogenicity of Streptococcus pneumoniae was assessed. A clpL mutant adhered to and invaded nasopharyngeal or lung cells much more efficiently than the wild type adhered to and invaded these cells in vitro, as well as in vivo, although it produced the same amount of capsular polysaccharide. However, the level of secretion of tumor necrosis factor alpha (TNF-α) from macrophages infected with the clpL mutant was significantly lower than the level of secretion elicited by the wild type during the early stages of infection. Interestingly, treatment of the human lung epithelial carcinoma A549 and murine macrophage RAW 264.7 cell lines with cytochalasin D, an inhibitor of actin polymerization, increased adherence of the mutant to the host cells. In contrast, cytochalasin D treatment of RAW 264.7 cells decreased TNF-α secretion after infection with either the wild type or the mutant. However, pretreatment of cell lines with the actin polymerization activator jasplakinolide reversed these phenotypes. These findings indicate, for the first time, that the ClpL chaperone represses adherence of S. pneumoniae to host cells and induces secretion of TNF-α via a mechanism dependent upon actin polymerization during the initial infection stage.