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- 저자 : Nilda Mendoza (검색결과 2 건)
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Miriam Noa,Sarah Mendoza,Rosa Mas,Nilda Mendoza 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
D-003 is a mixture of very-high-molecular-weight aliphatic primary acids purified from sugar cane wax, whereinoctacosanoic acid is the most abundant. Experimental and clinical studies have shown that D-003 lowers cholesterol and pre-vents plasma lipoprotein peroxidation (LP). D-003 has protected against the histological changes characteristic of CCl4- andparacetamol-induced hepatic injury in rats, in which LP plays a pivotal role for explaining the resulting hepatotoxicity. Galac-tosamine induces hepatotoxicity associated with depressed RNA and protein synthesis, not with LP. The aim of this studywas to evaluate whether D-003 could prevent hepatoxicity induced by mechanisms others than increased LP. We investigatedthe effects on galactosamine hepatotoxicity in rats distributed into five groups: a negative control group, a positive controlgroup, and three groups treated with galactosamine and D-003 (5, 25, and 100 mg/kg). To induce liver damage, galactosamine(800 mg/kg) was injected intraperitoneally 30 minutes after dosing with vehicle or D-003. Twenty-four hours later, rats weresacrificed, and livers were immediately removed for histopathological studies. Livers from positive controls showed the char-acteristic pattern of galactosamine-induced damage. Galactosamine significantly reduced the percentage of normal hepato-cytes, increasing both necrotic or lipid-rich hepatocytes compared with negative controls. D-003, however, did not increasethe percentage of normal hepatocytes compared with positive controls, indicating that treatment was not effective for pre-venting the hepatic injury induced with galactosamine. Likewise, D-003 failed to change the content of necrotic and lipid-rich hepatocytes relative to positive controls. It is concluded that D-003 did not protect against the histological changes ofgalactosamine-induced hepatotoxicity.
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Ariadne Gutie´rrez Martı´nez,Balia Pardo,Rafael Ga´mez,Rosa Mas,Miriam Noa,Gisela Marrero,Maikel Valle,Haydee Garcı´a,Dayisell Curveco,Nilda Mendoza,Edy Goicochea 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.12
D-004 is a lipid extract obtained from Cuban royal palm fruits, consisting of a mixture of free fatty acids, that prevents prostate hyperplasia induced with testosterone in rodents. This study investigated the possible alterations due to D-004 of androgen-dependent development after exposure in utero and compared them with those due to finasteride. Rats were randomized into five experimental groups: a control group, three groups treated with D-004 at 500, 750, or 1,000 mg/kg/day,respectively, and a group treated with finasteride (10 mg/kg/day). Male rats were treated 10 weeks before and during mating. Female rats were treated for 15 days prior mating, during mating, during pregnancy, and until lactation (day 21) except for those treated with finasteride, which were only administered the drug on gestational days 12–21. All male offspring were monitored individually until necropsy after postnatal day 90. The results of the present study indicate that D-004 induced no alterations in androgen-dependent development after the exposure in utero. Also, the current study demonstrated a permanent reduction in anogenital distance and retention of nipples in adult male rats exposed to finasteride during late gestation. Significant alterations induced by exposure to finasteride were mainly in tissues dependent on dihydrotestosterone during development.
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