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- 저자 : Nicole Bon Campomayor (검색결과 2 건)
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Comparative triple-color FISH mapping in eleven Senna species using rDNA and telomeric repeat probes
Thi Hong Nguyen,Nomar Espinosa Waminal,이도신,Remnyl Joyce Pellerin,Thanh Dat Ta,Nicole Bon Campomayor,Byung Yong Kang,김현희 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.6
Senna is a diverse and paraphyletic genus in the subfamily Caesalpinioideae (Fabaceae Lindl.) comprising various speciesof industrial and medicinal value. To date, the genome-based taxonomic relationship among several Senna species remainsenigmatic. Cytogenetic information is invaluable in deciphering phylogenetic relationships and evolutionary history. However,insuffi cient chromosomal research for many Senna species impedes comparative cytotaxonomic analyses aimed at understandingtheir genomic evolution. To provide additional Senna -related molecular cytogenetic information, we karyotyped11 Senna species by employing triple-color fl uorescence in situ hybridization using 5S rDNA, 45S rDNA, and Arabidopsisthaliana -type telomeric pre-labeled oligonucleotide probes. Chromosome numbers were predominantly 2 n = 28, but 2 n = 22( S. marilandica ) and 2 n = 24 ( S. unifl ora ) were also observed. While most species revealed only one interstitial 5S rDNAlocus, except for S. unifl ora which has two loci, a range of one to three 45S rDNA loci were detected at distal chromosomalregions. Additionally, we observed a hemizygous 45S rDNA locus in S. auriculata . In addition to chromosome termini,weak signals for telomeric repeats were found in interstitial regions in S. hirsuta, S. corymbosa , and S. alexandrina . Thesecytogenetic data can be integrated with molecular phylogenetic data for more comprehensive Senna cytotaxonomic analyses.
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( Darlene Mae D. Ortiz ),( Mikyung Kim ),( Hyun Jun Lee ),( Chrislean Jun Botanas ),( Raly James Perez Custodio ),( Leandro Val Sayson ),( Nicole Bon Campomayor ),( Chaeyeon Lee ),( Yong Sup Lee ),( J 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.2
Major depressive disorder is a leading cause of disability in more than 280 million people worldwide. Monoamine-based antidepressants are currently used to treat depression, but delays in treatment effects and lack of responses are major reasons for the need to develop faster and more efficient antidepressants. Studies show that ketamine (KET), a PCP analog, produces antidepressant effects within a few hours of administration that lasts up to a week. However, the use of KET has raised concerns about side effects, as well as the risk of abuse. 4 -F-PCP analog is a novel PCP analog that is also an NMDA receptor antagonist, structurally similar to KET, and might potentially elicit similar antidepressant effects, however, there has been no study on this subject yet. Herein, we investigate whether 4-F-PCP displays antidepressant effects and explored their potential therapeutic mechanisms. 4-F-PCP at 3 and 10 mg/kg doses showed antidepressant-like effects and repeated treatments maintained its effects. Furthermore, treatment with 4-F-PCP rescued the decreased expression of proteins most likely involved in depression and synaptic plasticity. Changes in the excitatory amino acid transporters (EAAT2, EAAT3, EAAT4) were also seen following drug treatment. Lastly, we assessed the possible side effects of 4-F-PCP after long-term treatment (up to 21 days). Results show that 4-F-PCP at 3 mg/kg dose did not alter the cognitive function of mice. Overall, current findings provide significant implications for future research not only with PCP analogs but also on the next generation of different types of antidepressants.
ScienceON
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