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- 저자 : Nehal (검색결과 24 건)
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Nehal Salahuddin,Ebtisam Mohamed Ibrahim,Maged El Kemary 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
The development of a facile method for preparing electrospun artesunate-loaded inorganic/organic compositenanofiber drug delivery systems will significantly enhance the therapeutic applications of artesunate as a novel anticancermedication. Herein, artesunate- loaded citrate-functionalized hydroxyapatite nanorods (ART@Cit-HAp NRs) were prepared,and then encapsulated into PLA nanofibers (ART@Cit-HAp NRs/PLA composite nanofibers) via the electrospinningmethod. The produced Cit-HAp NRs, ART@Cit-HAp NRs and ART@Cit-HAp NRs/PLA composite nanofibers werecharacterized using a variety of comprehensive techniques. Electrospun PLA nanofibers have a smooth surface and ahomogeneous diameter without any grains on the surface. The as-prepared citrate functionalized hydroxyapatite nanorodsshowed the high drug-loading efficiency of ~92 %. The mechanism of pseudo-second-order adsorption is the most prominentmodel for ART adsorption on Cit-HAp NRs. The in vitro ART release from the composite nanofibers (ART@Cit-HAp NRs/PLA composite nanofibers) was investigated and compared to ART@Cit-HAp NRs under different pH conditions. The ARTreleased from the ART@Cit-HAp NRs/PLA composite nanofibers in a sustained, slow rate was in contrast to Cit-HAp NRsand dependent on the pH of the medium. The in vitro antitumor activity of nanoformulations were evaluated on two coloncancer (CaCo-2 and HCT 116) cell lines. The findings revealed that ART@Cit-HAp NRs/PLA composite nanofibersdemonstrated higher anti-proliferating activity compared to free ART, and the pH-triggered release of ART@Cit-HAp NRs/PLA composite nanofibers are interesting prospects for colon cancer treatment.
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Nehal Mohamed El Koofy,Hanaa Ibrahim Rady,Shrouk Moataz Abdallah,Hafez Mahmoud Bazaraa,Walaa Ahmed Rabie,Ahmed Ali El-Ayadi 대한소아청소년과학회 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.9
Background: Ventilator dependency constitutes a major problem in the intensive care setting. Malnutrition is considered a major determinant of extubation failure, however, attention has been attracted to modulating carbon dioxide production through decreasing carbohydrate loading and increasing the percent of fat in enteral feeds. The detected interrelation between substrate oxidation and ventilation outcome became the base of several research to determine the appropriate composition of the nonprotein calories of diet in ventilated patients. Purpose: We aimed to assess the effect of high-fat dietary modification and nutritional status on ventilatory and final outcomes of pediatric intensive care. Methods: Fifty-one ventilated children (1 month to 12 years of age) with pulmonary disease who could be enterally fed, in the Cairo University Pediatric intensive care unit, were divided into 2 groups: group A included 25 patients who received isocaloric high-fat, low-carbohydrate diet; group B included 26 patients who received standard isocaloric diet. Comprehensive nutritional assessment was done for all patients. Results: Group A had a significant reduction in carbon dioxide tension, but no similar reduction in the duration or level of ventilatory support. Assisted minute ventilation was predicted by weight-for-age and caloric intake rather than the type of diet. Poor nutritional status was associated with higher mortality and lower extubation rates. Mild hypertriglyceridemia and some gastrointestinal intolerance were significant in group A, with no impact on the adequacy of energy or protein delivery. Conclusion: The high-fat enteral feeding protocol may contribute to reducing carbon dioxide tension, with mild hypertriglyceridemia and negligible gastrointestinal intolerance as potential adverse effects. Optimization of nutritional status rather than dietary modification may improve ventilatory and survival outcomes in critically ill-ventilated children.
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Parameter Selection Procedure for an Amplitude- and Rate-saturated Controller
Nehal Baiomy,Ryo Kikuuwe 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.4
This paper presents a selection procedure to obtain parameter values of the authors’ previously proposedamplitude- and rate-saturated controller. This controller employs a state-dependent parameter that enlarges theregion of attraction when the state is far from the origin and shrinks the finite-time attractor when the state is close tothe origin. The proposed selection procedure involves a set of linear matrix inequalities and also includes iterativecomputation. Two numerical examples for stable and unstable systems show the effectiveness of the proposedselection procedure.
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Nehal Salahuddin,Ahmed A. Elbarbary,Hend A. Alkabes 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.1
Polypyrrole/chitosan (PPC) spherical dark nanoparticles surrounded by shadow spheres were fabricated through in situ oxidative polymerization of pyrrole in presence of chitosan (CS) using ferric chloride (FeCl3) as oxidant and evaluated as a carrier for some amino-quinazolinone derivatives (I–IV). The loading of amino-quinazolinone derivatives (I–IV) into the core–shell nanoparticles were investigated by thermal gravimetric analysis (TGA). Quinazolinone derivatives (I–IV) loaded nanoparticles showed inter-connected sphere in necklace-like morphology, rods or filaments depending on the functional groups in quinazolinone derivatives. The release of quinazolinone derivatives from PPC nanoparticles was pH sensitive. The antimicrobial activity of loaded PPC nanoparticles against gram positive and gram negative bacteria was higher than CS and PPC nanoparticles. The results revealed that new generation of nanoparticles loaded with quinazolinone represent a potential platform to target breast cancer cell line (MCF7), Ehrlich ascites carcinoma (EAC) cells and liver cancer cells (HEPG2) in comparison with PPC and quinazolinone derivatives.
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Mohamed Nehal,Aziz Moustafa,Bashter Ibrahim 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.2
Monte Carlo N‐Particle eXtended (MCNPX) computer code was used to design heterogeneous and homogeneous models for the inner and the outer assemblies of a 3600 MWth fast breeder reactor cooled by sodium which is used for next-generation IV reactors. The purpose of the models is to test the adequacy of the lattice homogenization methods for calculations of the neutronic parameters of the assemblies. The multiplication factor, power distributions, and isotopic transmutation were studied and compared using both heterogeneous and homogeneous models. The results indicate that the two models are in good agreement in all cases.
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Predictive Value of Serum Insulin-like Growth Factor-1 in Hepatocellular Carcinoma
Elmashad, Nehal,Ibrahim, Wesam Salah,Mayah, Wael Wahid,Farouk, Mohamed,AboAli, Lobna,Taha, Atef,Elmashad, Wael Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Insulin-like growth factor-1 (IGF-1) levels reflect hepatic function and are inversely correlated with the severity of background chronic liver disease. Objective: This study evaluated whether basal serum IGF-1 levels can predict prognosis of HCC patients according to different risks of disease progression. Materials and Methods: A total of 89 patients with hepatocellular carcinoma (HCC) were recruited in 3 groups: Group I, 30 HCC patients receiving sorafinib; Group II, 30 HCC patients with best supportive care; and Group III include 29 patients undergoing transcatheter arterial chemoembolization (TACE). All patients were investigated for serum levels of AST, ALP, Bb, Cr, BUN, AFP and IGF-I. Results: Patients with disease control had significantly higher baseline IGF-1 levels 210 (185-232.5) ng/mL (p value<0.01) than did patients without disease control. Low basal IGF-1 levels were associated with advanced HCC, such as multiple tumors and advanced stage, and low IGF-1 levels predicted shorter TTP and overall survival in patients treated with TACE. Conclusions: The levels of serum IGF-1, expressed as continuous values, may be helpful for accurately assessing hepatic function and the prognostic stratification of patients with HCC.
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El Koofy, Nehal,Eldin, Hadeer Mohamed Nasr,Mohamed, Wesam,Gad, Mostafa,Tarek, Sara,El Tagy, Gamal The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.9
Background: Malnutrition has a high incidence among pediatric surgical patients and contributes to increased risks of postoperative complications and extended hospital stays. Purpose: The present study aimed to determine the influence of preoperative nutritional status on the postoperative outcomes of pediatric patients who underwent elective gastrointestinal (GI) surgery. Methods: This prospective observational study was conducted at Cairo University Specialized Pediatric Hospital. According to the designated inclusion criteria, 75 surgical cases of both sexes were included. A structured questionnaire was developed and administered. This questionnaire included 3 main sections: demographic data and nutritional status parameters at admission and discharge. Pre- and postoperative nutritional statuses were compared. Results: According to both the subjective global nutritional assessment and STRONGKIDS score Questioner, more than 60% of patients in the upper GI patient group were at risk of malnutrition. Wasting status was most common in the upper GI patient group (67%; vs. 39.1% in the lower GI group). Underweight status was more common in the hepatobiliary and upper GI patient groups (nearly 50% for each group) than in the lower GI group (30.4%). On the other hand, stunted patients had a higher incidence of complications and a prolonged hospital stay (P=0.003 and P=0.037, respectively), while underweight lower GI patients experienced a prolonged hospital stay (P=0.02). A higher proportion of patients with preoperative anemia than those without preoperative anemia required a blood transfusion (P=0.003). Conclusion: Nutritional assessment is a crucial component of pediatric surgical patient management. Both underweight and wasting statuses were more common among hepatobiliary and upper GI patients. Postoperative complications and a long hospital stay were more common among stunted patients.
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El-koofy Nehal M.,Fattouh Aya M.,Ramadan Areef,Elmonem Mohamed A.,Hamed Dina H. 대한소아청소년과학회 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.8
Background: Dyslipidemia is a major health problem among children and adolescents worldwide due to its significant association with cardiovascular disease. Primary dyslipidemias are commonly familial syndromes that can be completely asymptomatic.Purpose: Apart from the risk of coronary artery disease (CAD), limited data are currently available on the direct effects of dyslipidemia on myocardial function in children.Methods: We recruited 25 children with primary dyslipidemia (14 with isolated hypercholesterolemia, 4 with isolated hypertriglyceridemia, and 7 with combined dyslipidemia). Relevant clinical manifestations and laboratory and radiological investigations were evaluated. Pulsed-wave Doppler and tissue Doppler imaging echocardiography were performed for all recruited patients and the results were compared with those of 15 age- and sex-matched healthy children.Results: The median age of the dyslipidemic children was 8 years (range, 1.5–16 years). A family history was documented in 13 cases (52%), while 18 (72%) had consanguineous parents. None of the dyslipidemic children had a personal history or clinical manifestations of CAD. In contrast, echocardiographic findings differed in several diastolic function parameters of both right and left ventricles in dyslipidemic children compared to controls. Based on normalized z scores, aortic valve narrowing was detected in 7 patients (28%), while narrowing of the aortic sinus (sinus of Valsalva) was detected in 15 patients (60%).Conclusion: Different types of primary dyslipidemia produce functional myocardial abnormalities early in childhood. Biochemical and echocardiographic screening of high-risk children is advised to minimize the incidence of serious cardiovascular complications.
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El Koofy, Nehal Mohamed,Rady, Hanaa Ibrahim,Abdallah, Shrouk Moataz,Bazaraa, Hafez Mahmoud,Rabie, Walaa Ahmed,El-Ayadi, Ahmed Ali The Korean Pediatric Society 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.9
Background: Ventilator dependency constitutes a major problem in the intensive care setting. Malnutrition is considered a major determinant of extubation failure, however, attention has been attracted to modulating carbon dioxide production through decreasing carbohydrate loading and increasing the percent of fat in enteral feeds. The detected interrelation between substrate oxidation and ventilation outcome became the base of several research to determine the appropriate composition of the nonprotein calories of diet in ventilated patients. Purpose: We aimed to assess the effect of high-fat dietary modification and nutritional status on ventilatory and final outcomes of pediatric intensive care. Methods: Fifty-one ventilated children (1 month to 12 years of age) with pulmonary disease who could be enterally fed, in the Cairo University Pediatric intensive care unit, were divided into 2 groups: group A included 25 patients who received isocaloric high-fat, low-carbohydrate diet; group B included 26 patients who received standard isocaloric diet. Comprehensive nutritional assessment was done for all patients. Results: Group A had a significant reduction in carbon dioxide tension, but no similar reduction in the duration or level of ventilatory support. Assisted minute ventilation was predicted by weight-for-age and caloric intake rather than the type of diet. Poor nutritional status was associated with higher mortality and lower extubation rates. Mild hypertriglyceridemia and some gastrointestinal intolerance were significant in group A, with no impact on the adequacy of energy or protein delivery. Conclusion: The high-fat enteral feeding protocol may contribute to reducing carbon dioxide tension, with mild hypertriglyceridemia and negligible gastrointestinal intolerance as potential adverse effects. Optimization of nutritional status rather than dietary modification may improve ventilatory and survival outcomes in critically ill-ventilated children.
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