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Neely Ivgy-May,Qing Chang,Annpey Pong,Andrew Winokur 대한수면연구학회 2020 Journal of sleep medicine Vol.17 No.1
Objectives: This 52-week, double-blind, randomized, Phase 3 study evaluated the long-term safety of esmirtazapine 1.5 mg and 3.0 mg in elderly outpatients (aged ≥65 years) with insomnia. Methods: Participants were randomized to receive esmirtazapine 1.5 mg or 3.0 mg administered once nightly. Safety and tolerability (primary objectives) were assessed via adverse event (AE) reporting, routine clinical measurements [vital signs; electrocardiogram (ECG); laboratory parameters], and residual-effects assessments. Total sleep time (TST), wake time after sleep onset (WASO), and sleep latency (SL) were assessed (secondary objectives). Results: Of 259 randomized participants, 153 completed treatment. AEs and serious AEs were reported by 89.8% and 7.0%, respectively, of 1.5 mg recipients, and 88.5% and 3.8%, respectively, of 3.0 mg recipients. Discontinuations due to AEs were reported in 16.4% and 18.3% of participants receiving esmirtazapine 1.5 mg and 3.0 mg, respectively. The most frequent AEs (>10%) were nasopharyngitis, somnolence, dizziness, headache, dry mouth, weight increase, and fatigue. One participant died; the death was judged unrelated to treatment. Elevated eosinophil counts were noted, but not considered clinically significant. No remarkable or clinically relevant changes in laboratory parameters, vital signs, or ECG were observed. There was no evidence of residual effects; alertness at awakening increased by a median of 17 (1.5 mg) and 15 (3.0 mg) points from baseline, respectively, and ability to work/function by 12 points (both groups; all p<0.0001). Improvements from baseline in TST, WASO, and SL were observed. Conclusions: Esmirtazapine was reasonably tolerated in elderly outpatients with insomnia. No significant safety signals were observed.
Sensor Fusion-Based Middleware for Smart Homes
Lorcan Coyle,Steve Neely,Graeme Stevenson,Mark Sullivan,Simon Dobson,Paddy Nixon 한국과학기술원 인간친화 복지 로봇 시스템 연구센터 2007 International Journal of Assistive Robotics and Me Vol.8 No.2
Smart homes are sensor-rich environments that contain dynamic sets of interacting components. These components often use competing and closed standards and form a message-based architecture. This complicates the development of applications that require information from disparate sources. It becomes difficult to add new components or to allow components from different applications to interact with each another. In this paper we describe Construct, a pervasive computing middleware that is ideally suited for deployment in the smart home. Construct acts as a sensor fusion layer that takes output from each smart home component and makes it available to all applications. This makes it easy to develop applications that require access to heterogeneous sources of sensor data, and to add sensors to existing systems to improve their performance. This paper demonstrates two Construct-enabled smart home applications and shows how access to new sensors leads to improvements in their performance.
이종수,Jose-Miguel Yamal,Lu Wang,E. Neely Atkinson,Roderick Price,Andrés F. Zuluaga,Pierre Lane,Calum MacAulay,Dennis D. Cox,Michele Follen 계명대학교 자연과학연구소 2014 Quantitative Bio-Science Vol.33 No.2
Fluorescence spectroscopy has been investigated as a means of detecting oral, lung and cervical neoplasia. However, there are many issues in developing a clinical protocol for routinely making such measurements. We conducted an experiment with a simulated gynecological patient to study the effect of room light and speculum type. The speculum is needed for the medical provider to access the cervix. We investigated whether: (1) room lights present or absent had an effect and (2) the type of speculum (no speculum, coated speculum, or metal speculum) made a difference. In recent years, simulation-based medicine has gained prominence in clinical science. A simulated gynecological model was employed as a surrogate for a human cervix, which provides a physical environment similar to the clinical setting and mitigates ethical considerations. Measurements on fluorescence standards placed inside the simulated patient were made at all combinations of lighting and speculum type. Both light and the type of speculum were significant factors, and there was a statistically significant interaction between the two factors. When the room light was absent, the measurements made with either the metal speculum and the coated speculum did not exhibit significant differences, so either type of speculum may be used when the lights are absent. When the lights are present, the coated speculum shows less room light contamination in the measurements. Because the room light can contaminate the fluorescence spectroscopic measurements, making the measurement with room lights absent is highly recommended.
열처리로 제조된 물결모양 와이어 철망 층 구조의 압축강도
최정호(J. H. Choi),이정환(J. H. Lee),Krishna Shankar,Murat Tahtali,Andrew Neely 한국소성가공학회 2012 한국소성가공학회 학술대회 논문집 Vol.2012 No.5
The objective in this paper presents an attempt to understand and characterize the behavior of corrugated wire mesh laminates (CWML) under transverse compression loading. Specimens of the CWML are made of stainless steel type 316 woven metal and crossed points in the mesh are bonded with eutectic at low temperature. Experimental testing is conducted on several samples of single layer, two layer, and four layer wire mesh laminates under transverse compression The load deflection behaviors of the single and multi layer laminates observed in the tests are analyzed. Therefore, it does provide significant insight into aspects that influence the deformation behavior of CWML.
Vincent Dennis,Melissa Craft,Dale Bratzler,Melody Yozzo,Denise Bender,Christi Barbee,Stephen Neely,Margaret Robinson 한국보건의료인국가시험원 2019 보건의료교육평가 Vol.16 No.-
Purpose: This study investigated changes in students’ attitudes using 2 validated interprofessional survey instruments—the Collaborative Healthcare Interdisciplinary Relationship Planning (CHIRP) instrument and the Interprofessional Attitudes Scale (IPAS)—before and after didactic and clinical cohorts. Methods: Students from 7 colleges/schools participated in didactic and clinical cohorts during the 2017–2018 year. Didactic cohorts experienced 2 interactive sessions 6 months apart, while clinical cohorts experienced 4 outpatient clinical sessions once monthly. For the baseline and post-cohort assessments, 865 students were randomly assigned to complete either the 14-item CHIRP or the 27-item IPAS. The Pittman test using permutations of linear ranks was used to determine differences in the score distribution between the baseline and post-cohort assessments. Pooled results were compared for the CHIRP total score and the IPAS total and subdomain scores. For each score, 3 comparisons were made simultaneously: overall baseline versus post-didactic cohort, overall baseline versus post-clinical cohort, and post-didactic cohort versus post-clinical cohort. Alpha was adjusted to 0.0167 to account for simultaneous comparisons. Results: The baseline and post-cohort survey response rates were 62.4% and 65.9% for CHIRP and 58.7% and 58.1% for IPAS, respectively. The post-clinical cohort scores for the IPAS subdomain of teamwork, roles, and responsibilities were significantly higher than the baseline and post-didactic cohort scores. No differences were seen for the remaining IPAS subdomain scores or the CHIRP instrument total score. Conclusion: The IPAS instrument may discern changes in student attitudes in the subdomain of teamwork, roles, and responsibilities following short-term clinical experiences involving diverse interprofessional team members.
Wang, Nai-Yu,Patras, Kathryn A.,Seo, Ho Seong,Cavaco, Courtney K.,Rö,sler, Berenice,Neely, Melody N.,Sullam, Paul M.,Doran, Kelly S. Oxford University Press 2014 The Journal of Infectious Diseases Vol.210 No.6
<P>Group B streptococcus (GBS) can cause severe disease in susceptible hosts, including newborns, pregnant women, and the elderly. GBS serine-rich repeat (Srr) surface glycoproteins are important adhesins/invasins in multiple host tissues, including the vagina. However, exact molecular mechanisms contributing to their importance in colonization are unknown. We have recently determined that Srr proteins contain a fibrinogen-binding region (BR) and hypothesize that Srr-mediated fibrinogen binding may contribute to GBS cervicovaginal colonization. In this study, we observed that fibrinogen enhanced wild-type GBS attachment to cervical and vaginal epithelium, and that this was dependent on Srr1. Moreover, purified Srr1-BR peptide bound directly to host cells, and peptide administration in vivo reduced GBS recovery from the vaginal tract. Furthermore, a GBS mutant strain lacking only the Srr1 “latching” domain exhibited decreased adherence in vitro and decreased persistence in a mouse model of GBS vaginal colonization, suggesting the importance of Srr–fibrinogen interactions in the female reproductive tract.</P>
Advanced pathophysiology mimicking lung models for accelerated drug discovery
Thanh Huyen Phan,Huaikai Shi,Christopher E. Denes,Alexander J. Cole,Yiwei Wang,Yuen Yee Cheng,Daniel Hesselson,Susan H. Roelofs,Graham Gregory Neely,Jun‑Hyeog Jang,Wojciech Chrzanowski 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Respiratory diseases are the 2nd leading cause of death globally. The current treatments for chronic lung diseases are only supportive. Very few new classes of therapeutics have been introduced for lung diseases in the last 40 years, due to the lack of reliable lung models that enable rapid, cost-effective, and high-throughput testing. To accelerate the development of new therapeutics for lung diseases, we established two classes of lung-mimicking models: (i) healthy, and (ii) diseased lungs – COPD. Methods To establish models that mimic the lung complexity to different extents, we used five design components: (i) cell type, (ii) membrane structure/constitution, (iii) environmental conditions, (iv) cellular arrangement, (v) substrate, matrix structure and composition. To determine whether the lung models are reproducible and reliable, we developed a quality control (QC) strategy, which integrated the real-time and end-point quantitative and qualitative measurements of cellular barrier function, permeability, tight junctions, tissue structure, tissue composition, and cytokine secretion. Results The healthy model is characterised by (i) continuous tight junctions, (ii) physiological cellular barrier function, (iii) a full thickness epithelium composed of multiple cell layers, and (iv) the presence of ciliated cells and goblet cells. Meanwhile, the disease model emulates human COPD disease: (i) dysfunctional cellular barrier function, (ii) depletion of ciliated cells, and (ii) overproduction of goblet cells. The models developed here have multiple competitive advantages when compared with existing in vitro lung models: (i) the macroscale enables multimodal and correlative characterisation of the same model system, (ii) the use of cells derived from patients that enables the creation of individual models for each patient for personalised medicine, (iii) the use of an extracellular matrix proteins interface, which promotes physiological cell adhesion and differentiation, (iv) media microcirculation that mimics the dynamic conditions in human lungs. Conclusion Our model can be utilised to test safety, efficacy, and superiority of new therapeutics as well as to test toxicity and injury induced by inhaled pollution or pathogens. It is envisaged that these models can also be used to test the protective function of new therapeutics for high-risk patients or workers exposed to occupational hazards.