The extent of anglo-sanskrit parallelism in vocabulary and its bearings on the science of language

Nath, Narendra Chandra Banaras Hindu University 1967 해외박사

Nonlinear Control Techniques for Robot Manipulators : Nonlinear Control of Mechatronic Systems with Applications in Robotics

Nath, Nitendra VDM Verlag Dr. Mueller 2008 국내석사

Association Control based Load Balancing for Tactical Information Communication Networks

Nath, Kiran T. 서울대학교 대학원 2009 국내석사

Fabrication and Characterization of PLGA microspheres and incorporating them in the porous and incorporating them in the porous scaffold for drug delivery system and bone regeneration

Deb Nath, Subrata Graduate School, Soonchunhyang University 2013 국내석사

Enhancement and polarization manipulation of photonic spin hall effect with waveguided-SPR method

Monu Nath Baitha Graduate School, Yonsei University 2023 국내박사

광자 스핀 홀 효과(Photonic spin Hall effect, PSHE)는 plane-polarized wave가 광 표면에서 반사와 굴절 이후 right and left-handed circularly-polarized wave로 분리되는 현상이다. 광자 스핀 홀 효과는 전자의 홀 효과와 매우 유사하며, 다양한 모델과 구조내에서 연구되어 왔지만 아직까지 그 수치가 작고 편광에 의존적이어서 현실적으로 적용하기 어렵다. 플라즈모닉 시스템에서 스핀 홀 효과의 증폭은 가능했으나, 수평 편광이라는 조건에 한정되어 있었다. 광자 스핀 홀 효과를 더 증폭시키고 편광 의존성을 제어하기 위해 새로운 도파로-표면 플라즈몬 공명 (Waveguided surface plasmon resonance, WG-SPR) 방법을 채택하였다. 본 논문에서의 사용한 구조는 금속층 위의 얇은 유리층으로 구성되어 있으며, 수직 및 수평 편광 모두 적용이 가능하다. 입사광의 편광 상태는 광자 스핀 홀 효과에 상당한 영향을 미친다. 본 논문은 도파로-표면 플라즈몬 공명을 이용한 거대 광자 스핀 홀 효과를 이론적으로 분석하였으며, 그 수치를 밀리미터 수준까지 향상시켰다. 이 연구는 플라즈몬 공명 기반 모델을 사용하여 빛의 수직 및 수평 편광 모두에 대해 거대 광자 스핀 홀 효과를 관찰한 첫 번째 연구이다. 또한, 도파관의 층 두께를 조정함으로써 편광을 능동적으로 조작할 수 있으며, 이러한 효과는 광 스핀을 주로 이용하는 수직 및 수평 편광 기반의 양자 광학 장치 및 센서에 적용할 수 있다. 더 나아가, 편광의 전환이 가능한 스핀 광자 홀 효과를 얻기 위해 새로운 방법을 제안하였다. 결과적으로 구조의 물리적인 변화없이 광자 스핀 홀 효과를 관찰 할 수 있다. 이 연구는 광자 스핀 홀 효과를 향상시키는 입사 공명 각도만 변경하여 편광 모드를 능동적으로 제어하는 데 매우 적합하며, 이러한 효과는 스위치, 빔 스플리터, 필터 등의 광 편광 기반 장치에 적용할 수 있다. 또한, 모든 입사각에 대해 편광 독립적인 광자 스핀 홀 효과를 관찰 할 수 있는 연구를 진행하였다. 모든 입사각, 모든 평면 편광 입사파에 대해 수직 편광 광자 스핀 홀 효과와 수평 편광 광자 스핀 홀 효과가 같음을 보였다 (δ_±^H=δ_±^V). 이 연구는 모든 입사각에 대해 광자 스핀 홀 효과의 편광 의존성을 없애기 위해 빛의 스핀-궤도 결합을 조작한 첫 번째 연구이다. 이 연구의 결과는 편광 독립적인 양자 장치 및 센서에 적용할 수 있다. The photonic spin Hall effect (PSHE) explains the separation of right- and left-handed circularly-polarized waves after reflection and refraction of a plane-polarized wave from an optical interface. It is a direct analogy to the electronic Hall effect. To date, PSHE has been explored for many different models and structures, but still, its small value and polarization dependency limits the practical application. In plasmonic systems, the enhanced spin Hall effect (SHE) was previously possible but only for horizontal polarization. To further enhance the PSHE and control the polarization dependency, the novel waveguided surface plasmon resonance (WG-SPR) method has been adopted. The proposed structure comprises a thin glass layer over a metal layer that produces a hybrid mode of transverse magnetic and a regular waveguiding transverse electric mode. The polarization state of the incident light has a substantial impact on the photonic spin Hall effect (PSHE). This thesis reports a theoretical analysis of the giant photonic spin Hall effect (G-PSHE) using WG-SPR. An enhancement of millimeter-scale (more than 2 mm to submillimeter) is achieved. To the best of our knowledge, this is the first study to achieve G-PSHE for both vertical and horizontal polarization modes of light with the SPR-based model. Other findings also indicate the manipulation of active polarization mode by only tuning the wave-guiding layer thickness. This study enables the scope for potential applications of both H- and V-polarized based quantum optical devices and sensors, where light spin plays a pivotal role. Further, a novel method has been proposed to get the polarization-switchable PSHE. Outcomes offer the opportunity of eliminating any physical alteration of the given structure to govern the desired results. This research is highly suited to controlling the active polarization mode of enhanced PSHE by only altering the incident resonance angle. It will be a simple alternative for modern light polarization (spin) based devices such as switches, beam splitters, filters, etc. Furthermore, another study revealed an opportunity to polarization-independent photonic spin Hall effect (PSHE), for all incident angles. This work demonstrates that the horizontal (H) and vertical (V) polarized PSHE will remain the same; (�±ு = �±௏) for any plane-polarized incident wave at any incident angle. This is the first study where the Spin-Orbit coupling of light has been manipulated to vanish the polarization dependency of PSHE for all incident angles. The results of this study pave the way for feasible future applications of new polarization-independent quantum devices and sensors.

Anglo-Tibetan relations, 1899-1925

Addy, Premendra Nath British Library, Document supply centre 1975 국내박사

Toxicogenomics : an approach to identify the mechanistic insights of toxicity including gene based biomarkers with the exposure of volatile organic compounds(VOCs) to human leukemia cells

Sarma, Sailendra Nath University of Science and Technology 2011 국내박사

DYNAMICS OF HELMINTHIC INFECTIONS IN EPIDEMIC AND EPIZOOTIC SYSTEMS OF BANGLACESH

TILAK CHANDRA NATH 충북대학교 2022 국내박사

In view of a growing national and international commitment to control human helminths infection, there is an urgent need to intensify the cases detection from various reservoir hosts and the application of context-based diagnostic methods. The goal of this study was to deepen the understanding of helminthiases, perform a One Health based parasitological screening comprising humans, animals, and environmental samples from same ecological settings and assess feasibility of a diagnostic tool and control intervention in Bangladesh. The dissertation employed a combination of qualitative and quantitative methods including a series of parasitological techniques like copromicroscopy, scanning electron microscopy, experimental sedation, culture and molecular approach. Specimens (stools, soils, and adult helminths) were collected from humans, animals, and environment from the same communities (Dhaka, Chittagong and Chattogram) in Bangladesh. Structured questionnaires and an interventional study were used to collect data. Interviews were conducted among community people and related professionals. The examined host communities harbored diverse types of helminths that were heterogeneously distributed across the hosts. Out of 360 human stool samples, the prevalence of helminths infection was 31.7%. Interventional study showed that integration of new intervention with existing control programs was feasible in the local field settings of the country; however, several barriers like fragmented health delivery system, lack of interdisciplinary communication, and information gaps were dominantly existing. Additionally, this study presents the first human case of Rhabditis sp. infection in Bangladesh; emphasized for careful inspection to diagnose and differentiate the helminths species. Out of 550 fecal samples from animal, 59.6% was found positive for at-least one helminth. This study suggested a new, undescribed nematode, Agriostomum n. sp. (2021) from Black Bangal goat. In captive wild animals, 48.9% of examined fecal samples were found positive for parasitic infections. For the first time, zoonotically important Spirometra decipiens from lion was molecularly characterized in this study. Furthermore, geohelminth contamination was found in 52.5% of examined soil samples. This study also developed a context-based geohelminth diagnostic method and the method found feasible in terms of field applicability and egg recovery rate. And lastly, this study molecularly identified zoonotically important canine hookworms, Ancylstoma caninum from soil that represents a risk to public and animal health. This study assessed the prevalence of helminth infection in humen, animal, wild animal as well as geohelminth contamination, and provides a general overview of host-parasite interactions, diagnostic tools and control strategies of parasitic diseases in Bangladesh. Helminthiases remains dominant among the diverse host range, with a high rate of geohelminth contamination. The need of routine parasitological examination as part of current parasite control programs is highlighted in this study. Armed with this, the study propose One Health approach, integrating human, veterinary, and public health authorities in the development and implementation of parasitic diseases prevention and control strategies.

Investigating the role of elevated free fatty acids in epithelial-mesenchymal transition of hepatocellular carcinoma

Nath, Aritro Michigan State University 2015 해외박사(DDOD)

Hepatocellular carcinoma (HCC) is one of the deadliest forms of cancer world-wide with steadily increasing incidence and mortality rates in the United States. Advanced HCC are characterized by increased prevalence of intrahepatic and extrahepatic metastases, and are associated with very poor survival rates. Epidemiological studies indicate elevated free fatty acid (FFA) levels, the physiological manifestation of obesity, may be associated with higher mortality rates in HCC patients. Here, we investigated the effects of elevated FFA uptake on the induction of epithelial to mesenchymal transition (EMT) program -- a pathway involved in metastatic progression of human cancers. Our initial studies with saturated FFA palmitate (PA) revealed a significant loss of the obligate desmosomal protein desmoplakin (DSP) in HepG2 cells, indicating a loss of cell adhesion. We next observed enhanced migration and invasiveness in HepG2 and Hep3B cells in response to PA treatment and confirmed loss of cell adhesion in the two cell lines. PA treatment resulted in cytotoxicity and expression of EMT-markers in distinct populations within the treated cells. Additionally, we identified that the Wnt/beta-catenin and TGF-beta signaling pathways were activated, suggesting a possible mechanism of EMT induction by PA. We further assessed the association between CD36, a FFA uptake gene normally expressed at low levels in hepatocytes but found to be elevated in fatty liver, and the activation of EMT program in human HCC. Our analysis revealed a significant association between CD36 and expression of EMT markers in the cancer genome anatomy (TCGA) liver cancer mRNA expression dataset, which was confirmed with protein samples from human HCC tumor biopsies. Interestingly, both studies suggested that expression of EMT markers were not correlated with body mass index of the patients. Given the role of exogenous FFA uptake in promoting EMT and metastasis in HCC, we further analyzed somatic mutations, copy number variations, and gene expression profiles of fatty acid uptake and metabolism genes in context of metastatic progression in >8,000 samples from the TCGA database across 12-different cancer types. Our analysis revealed a significant and previously undocumented role of fatty acid uptake and fatty acid metabolism genes in the metastatic progression of multiple human cancers, and demonstrated the utility of genes involved in these pathways as strong prognostic biomarkers with significant influence on survival rates.

A Mystery of Muscle: Establishing Mechanisms of Toxicity in Polyglutamine Disease

Nath, Samir ProQuest Dissertations & Theses University of Mich 2022 해외박사(DDOD)

Polyglutamine disorders encompass nine uniformly fatal diseases for which there are no disease course altering therapies. This group of related diseases share a key source: expansion of a CAG microsatellite repeat in genes which code for widely different proteins. Downstream of expansion, protein misfolding and oligomerization lead to gain-of-function proteotoxicity. Ultimately, this toxicity leads to disruption of a multitude of signaling pathways, altered homeostasis, and selective cell death. The first discovered polyglutamine disease is caused by an expansion of a CAG microsatellite repeat in the gene coding for androgen receptor and is called Kennedy’s Disease or Spinobulbar Muscular Atrophy (SBMA). Patients with this repeat expansion develop progressive degeneration of the neuromuscular system and are ultimately wheelchair bound.While the cause of SBMA is well-defined, the downstream consequences of receptor expansion remain poorly understood. Recently, several studies have implicated skeletal muscle as playing an important role in the pathogenesis of disease. However, despite two decades of study, the cause of muscle atrophy in SBMA remains poorly defined.This thesis will first outline polyglutamine diseases with a focus on SBMA. In Chapter 2, I discuss the data characterizing protein quality control in polyglutamine disease with a focus on the ubiquitin-proteasome system (UPS), which is both an important therapeutic target and critical mediator of muscle atrophy downstream of other sources. In Chapter 3, this thesis provides primary data demonstrating the surprising finding of age-dependent proteasome impairment, suggesting the proteasome does not account for muscle atrophy in SBMA. In Chapter 4, this thesis will delve examine potential sources of muscle atrophy in SBMA, implicating a key regulator of muscle hypertrophy as a novel therapeutic target in disease. In Chapter 5, the question of whether SBMA is accurately characterized as a neurodegenerative disease will be discussed, with primary data provided comparing changes in SBMA skeletal muscle to those caused by models of myopathy and neuropathy. Together, this data identifies a novel source of muscle atrophy downstream of polyglutamine proteins and defines several key questions for future studies.