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Vibration-Isolation Characteristics in a Damped Vibration system with Thixotropic Materials
Sato, Taichi,Fujikawa, Naoki,Masuda, Hiromitsu,Tanaka, Kihachiro 대한기계학회 1996 International Sessions in Celebration of the 50th Vol.1 No.1
The dynamic behavior of a damped vibration system containing thixotropic materials is experimentally investigated. Thixotropic materials are substances that liquefy when they are stirred or shaken and return to the hardened state upon standing. We construct a vibration system containing thixotropic material and performed vibration tests using the vibration system with two rotating unbalances turning in opposite directions. The amplitudes of the transmitted force to the foundation and the displacement of the mass are measured. The tests indicate that the damped system containing thixotropic materials shows good vibration characteristics. As the consistency ol thixotropic materials increases, the transmitted force at resonance decreases, and even the degree of increase of the transmitted force at the higher values of the forcing frequency is smaller than in the experimental results of the viscous damper. These dynamic characteristics enable vibration to be significantly isolated in this system when the excitation frequency is changed.
Piras, Vincent,Selvarajoo, Kumar,Fujikawa, Naoki,Choi, Sang-Dun,Tomita, Masaru,Giuliani, Alessandro,Tsuchiya, Masa Korea Genome Organization 2007 Genomics & informatics Vol.5 No.3
MicroRNAs (miRNAs) are known to negatively control protein-coding genes by binding to messenger RNA (mRNA) in the cytoplasm. In innate immunity, the role of miRNA gene silencing is largely unknown. In this study, we performed microarray-based experiments using lipopolysaccharide (LPS)-stimulated macrophages derived from wild-type, MyD88 knockout (KO), TRIF KO, and MyD88/TRIF double KO mice. We employed a statistical approach to determine the importance of the commonality and specificity of miRNA binding sites among groups of temporally co-regulated genes. We demonstrate that both commonality and specificity are irrelevant to define a priori groups of co-down regulated genes. In addition, analyzing the various experimental conditions, we suggest that miRNA regulation may not only be a late-phase process (after transcription) but can also occur even early (1h) after stimulation in knockout conditions. This further indicates the existence of dynamic interactions between miRNA and signaling molecules/transcription factor regulation; this is another proof for the need of shifting from a 'hard-wired' paradigm of gene regulation to a dynamical one in which the gene co-regulation is established on a case-by-case basis.