관상동맥 스텐트 내 재협착의 발생에 미치는 임상적 관동맥 조영술적 요인들

윤혁준,김기식,박형섭,이영수,현대우,한성욱,허승호,김윤년,김권배,박남희,원경숙 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

한약수치에 관한 연구(제 9보) : 炒甘草 제법의 표준화 및 규격화(1) Preparing Standardization and Regulation of Stir-Frying Glycyrrhzia root(1)

최혁재,이우정,박성환,송보완,김동현,김남재 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

In this study, We carried out the preparing standardization and regulation of processed Glycyrrhizae Radix(PGR) which have been widely used in oriental medicines. Glycyrrhizae Radix(GR) have been generally prepared by the stir-frying, or mix-frying with honey for purpose of decreasing sweetness and augmenting vitality. Firstly, we tried to standardize PGR prepared by the stir-frying. We purchased 14 kinds of PGR and non-processed GR(NPGR) at oriental physician's offices and oriental pharmacies on a nation scale, respectively. The amounts of dry on loss, water extract, diluted ethanol extract, ether extract, total ash, acid insoluble ash, glycyrrhizin(GL), glycyrrhetic acid(GA) and liquiritin(LQ) of them were examined. The amounts of dray on loss, GL and LQ in commercial PGRs showed remarkable decrease, while GA showed increase as compared with NPGR. In order to standardize preparing method of PGR, the effect of heating time on physico-chemical parameters and biological activities were examined. Physico-chemical parameters such as dry on loss, extract amount, GL and LQ contents in PGRs showed decrease, however, GA was increased with heating time as compared with NPGR. Also, GA obtained form heat-treated GR, was found as an artifact in PGRs. PGR was more effective than NPGR in vitro test of DPPH scavenging effect and TBA-Rs reducing effect. PGR and NPGR showed potent hepatoprotective effect on CCl_(1)-intoxicated rats. Especially, PGR prepared by 80 min of heating was the most effective. Considering these results, the optimal condition for PGR preparation was 150℃ for 80min.

거대 관동맥류에 병발한 급성 심근 경색증 1예

윤혁준,김기식,허승호,박남희,조용원 대한순환기학회 2002 Korean Circulation Journal Vol.32 No.8

석이중 오르시놀 정량 및 급성독

최혁재,김남재,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-

In previous study, Gyrophora esculenta showed significant inhibitory effect on α-glucosidases in vitro and blood glucose elevation in vivo In the isolating process of active substance, orcinol was separated from Gyrophora esculenta. Orcinol is known to be toxic, therefore, in this study, it was analyzed by the TLC densitometry method for quantitative determination from Gyrophora esculenta. The average amount of orcinol of Gyrophora esculenta was 0.2%. For the purpose of removing orcinol, the water extract of Gyrophora esculenta was sequentially fractionated by organic solvents, and the acute toxicity of each fraction was assessed in mice. Among them, the LD50 of butanol fraction was 1.19 g/kg(p.o.) and the weight increase of mice in that group was somewhat retarded.

만성 화농성 중이염의 세균학적 고찰

조남순,이영훈,강기훈,최제환,송태현,이병돈,장혁순,강주원,김연준 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background and Objectives : Chronic suppurative otitis media is one of the frequent diseases in otolaryngologic field. It is important to choose of antibiotics in the management of infectious disease. But the organisms in infections have been changed and resistance to antibiotics has been grown as the development of antibiotics has been achieved. And so it has been necessary to recognize the changes of organisms and resistance in antibiotics. Our study was performed to identify the pathogens isolated from discharges in chronic otitis media and evaluate the antibiotic agents, to recognize the change of to resistance to·antibiotic agents and to use the appropriate anitiotics. Materials and Methods : Retrospectively, authors reviewed the backeriologic study of 114 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Soonchunhyang University in Seoul from Nov. 1996 to Oct. 1999 and analyzed 101 strains and its sensitivity test to various antibiotics. Result : In 93 cases in which pathogenic organism was isolated, single infection was 85 cases(91.4%) and mixed infection was 8 cases(8.6%). The most frequent pathogenic organism was Staphylococcus aureus(59.4%), Pseudomonas aeruginosa(13.9%), Providencia(4.8%), Alcaligenes(3.0%) and Streptococcus pneumoniae(2.9%) were the next. Methicilline-Resistance Staphylococcus aureus was 34 cases(57.6%) of Staphylococcus aureus. Staphylococcus aureus was sensitive to Vancomycin(96.7%), Trimethoprim-Sulfamethoxazole (57.6%), Cefuroxime(42.4%) and Ciprofloxacin(40.7%) but resistant to Penicillin(94.9%). Pseudomonas aeruginosa was sentitive Amikacin(100%), Ciprofloxacin(100%) and Gentamicin(67%). Conclusion : As MRSA recently was wide spread in community accquired infection as well as nosocomial infection, we must consider strict control of MRSA.

Jazz Dance 참여를 통한 여가만족도 효과 측정

배남은,김종혁,김도진 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This study is to evaluate effect's difference of Leisure Satisfaction Scale for Jazz Dance Attendance. It researched effectively for Jazz Dance Attendance and motive, It also offer a fundamental information of study related with Jazz Dance, This study processed a subject of middle aged woman who attended Jazz dance at Life Education Organization and Society Education Organization in Kyunggi-do S and A city during periodic time, The measurement implement is used the Ragheb & Beard's Leisure Satisfaction Scale. It used a demographic factors and attended feature factors 4 questionnaire, a psychological satisfaction factor 4 questionnaire, a physical satisfaction factors 4 questionnaire, an environmental satisfaction factors 3 questionnaire, an educational satisfaction factors 4 questionnaire, The confidence level is showed .79 ~.83. Data information analyze using SPSS version 11.0, It produced the M, SD for acquiring feature of responsor and fundamental data of study object, It used reliability analysis for acquiring Cronbach' a of research questionnaire, Also it is used one-way ANOVA and independent T-Test for difference verification between the group according to each variables. Suppose it has a significant difference, for using I Multiple comparison method, according to this step is the following results; First of all. It was showed a significant difference of a psychological and educational satisfaction factors by age 50. Second, It was showed a significant difference or a psychological and environmental satisfaction factors at an effect's difference of Leisure Satisfaction Scale by academic education lower high school. Third, it was showed a significant difference of a psychological, environmental, and educational satisfaction factors at an effect's difference of Leisure Satisfaction Scale by salary. Forth, it was not showed a significant difference of each factors at an effect's difference of Leisure Satisfaction Scale by attended time.

리튬 2차전지용 양극물질 Li_(x)Co_(⅓)Mn_(⅓)Ni_(⅓)O₂의 제조 및 특성

김남혁,장인영,강안수 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

Various activated cathode materials for lithium secondary battery were synthesized using metal precursors by co-precipitation, and final activated material was prepared by solid-state method. We prepared Li_(x)Co_(⅓)Ni_(⅓)Mn_(⅓)O₂ by changing lithium quantity. Three-electrode type cell was used with the cathode in which activated materials, and TAB(teflonized acetylene black) were mixed in the ratio of 80:20. The tested cell with Li_(x)Co_(⅓)Ni_(⅓)Mn_(⅓)O₂ exhibited excellent characteristics with x=1.06 lithium, showing efficiency of 89.24 %, charge capacity of 187.13 mAh/g and discharge capacity of 162.37 mAh/g at constant current 0.1 C in the range of 3.0 - 4.3 V, but showed capacity decrease of 3.08% at 20 cycles. The structures of the layered materials of the synthesized samples Li_(x)Co_(⅓)Ni_(⅓)Mn_(⅓)O₂, were characterized by XRD and SEM, and this sample was applicable to activated cathode materials of lithium secondary battery. The study indicated that the samples prepared by co-precipitation and successive solid-state method could help design and develop the composite cathode with high capacity and good cyclability.

석이에서 분리한 GE974의 α-Glucosidase 저해효과

최혁재,김남재,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

This study was conducted to search for the α-glucosidase inhibitor from the natural products. In the previous study, the water extract of Gyrophora esculenta exhibited a potent inhibitory effect on α-glucosidase activities. Then, by bioassay-guided fractionation followed by chromatographic seperation of the water extract of Gyrophora esculenta, α-glucosidase inhibitor was isolated as GE974. GE974 showed significant inhibitory activities on some kinds of α-glucosidases in vitro. Its inhibitory mechanism seemed to be competitive for disaccharides. Also, it markedly inhibited α-glucosidases of intestine separated from both nondiabetics and diabetics.

석이에서 분리한GE974의 혈당상승억제효과

최혁재,김남재,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

GE974, isolated from Gyrophora esculenta, showed significant inhibitory effect on several α-glucosidases in vitro in previous study. In the present study, GE974 showed significant inhibitory effect on blood glucose elevation in mice loaded with maltose, sucrose, starch and lactose. Also, it exhibited similar effect in alloxan and streptozotocin induced diabetic mice, and genetic diabetic mice(db/db mice) loaded with maltose in dose dependent manner. These results suggest that GE974 may possess hypoglycemic effect that inhibit competitively α-glucosidase activities.

동기 회전축상에 전류제어기를 구성한 유도전동기의 벡터제어계 특성에 관한 연구

權炳徽,任楠赫 홍익대학교 산업기술연구소 1994 産業技術 Vol.3 No.-

In this study, it was proposed Current Controller with componect represented in synchronous rotating coordinate which can be solve the fault of two level Hysteresis Current Controller for Vector Control System of Induction Motor. As a result of investigation for characteristics of dynamic and static operation throuth simulation, proposed Current Controller could make the current follow without phase error. And compared with Hysteresis Current Controller. Switching frequency decrease by 25 percent and it was convinced to have a merit that the amplitude of error current is limited within band.