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Bukke, Ravindra Naik,Avis, Christophe,Naik, Mude Narendra,Jang, Jin IEEE 2018 IEEE electron device letters Vol.39 No.3
<P>We report the effect of purification of ZrO<SUB>x</SUB> precursor on the performance of solution processed amorphous indium–zinc–tin oxide thin-film transistors with a ZrO<SUB>x</SUB> gate insulator, which is processed at the maximum temperature of 300 °C in air. By purification, the saturation mobility ( <TEX>$\mu _{\textit {sat}}$</TEX>) increases from 2.45 ± 0.83 to 15.42 ± 4.01 cm<SUP>2</SUP>V<SUP>−1</SUP>s<SUP>−1</SUP>, subthreshold swing decreases from 141.44 ± 14.08 to 87.90 ± 11.05 mV/decade and drain current ON/OFF ratio increases from ~10<SUP>7</SUP> to ~10<SUP>9</SUP>. The leakage currents are remarkably reduced by using purified ZrO<SUB>x</SUB> as a gate insulator. The improvement is mainly due to the reduced impurities and less oxygen vacancies in ZrO<SUB>x</SUB>.</P>
Naik, M.u.d.,Rather, S.u.,So, C.S.,Hwang, S.W.,Kim, A.R.,Nahm, K.S. Pergamon Press ; Elsevier Science Ltd 2009 International journal of hydrogen energy Vol.34 No.21
Thermogravimetric analysis of LiAlH<SUB>4</SUB> chemically mixed with different additives is reported for the application of hydrogen storage. Here, we illustrated the dehydrogenation properties of combined LiAlH<SUB>4</SUB>/LiNH<SUB>2</SUB> (2:1) mixture and LiAlH<SUB>4</SUB> wet-doped with different transition metals (Sc, Ti, and V) in their chloride forms. Thermal gravimetric analysis of LiAlH<SUB>4</SUB>/LiNH<SUB>2</SUB> system released ∼7.9wt.% of hydrogen in three decomposition steps at temperatures between 75 and 280<SUP>o</SUP>C under a heating ramp of 5<SUP>o</SUP>Cmin<SUP>-1</SUP>. The LiAlH<SUB>4</SUB> doped with transition metals showed the decrease of decomposition temperature down to 30-40<SUP>o</SUP>C for both 1st and 2nd dehydrogenation steps as compared to as-received LiAlH<SUB>4</SUB>. The catalytic activity in lowering the dehydrogenation temperature of LiAlH<SUB>4</SUB> doped with transition metals increases in the order of pure LiAlH<SUB>4</SUB><V<Ti<Sc. The X-ray diffraction analysis, field emission scanning electron microscopy, and Fourier transformation infra-red spectroscopy techniques were carried out in support of the thermogravimetric results.
Naik Parrikar Vishwaraj,Chandrika Thondagere Nataraj,Ravi Prasad Kogravalli Jagannath,Prashanth Gurusiddappa,Srinivas Talabattula 한국광학회 2020 Current Optics and Photonics Vol.4 No.4
In this paper we propose and theoretically analyze a monolithic multiparametric sensor consisting of a superstructure of surface-relief waveguide Bragg gratings (WBGs), a micro-machined diaphragm, and a cantilever beam. Diaphragms of two different configurations, namely circular and square, are designed and analyzed separately for pressure measurement. The square diaphragm is then selected for further study, since it shows relatively higher sensitivity compared to the circular one, as it incurs more induced stress when any pressure is applied. The cantilever beam with a proof mass is designed to enhance the sensitivity for acceleration measurement. A unique mathematical method using coupled-mode theory and the transfermatrix method is developed to design and analyze the shift in the Bragg wavelength of the superstructure configuration of the gratings, due to simultaneously applied pressure and acceleration. The effect of temperature on the wavelength shift is compensated by introducing another Bragg grating in the superstructure configuration. The measured sensitivities for pressure and acceleration are found to be 0.21 pm/Pa and 6.49 nm/g respectively.
Naik Aditi Venkatesh,Sellappan Krishnan 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
The use of plants as a source of palliative or treatment for cancer is quite widespread worldwide. Annona muricata L. (Graviola) exhibits a wide array of ethno-medicinal and curative properties, accredited to different plant organs. The bio-activity of this plant is characterized by the production of secondary metabolites like alkaloids, phenols and most importantly annonaceous acetogenins found uniquely in this plant group. While A. muricata is gaining recognition as anti-cancer treating plant, the present study was undertaken to affirm probable genotoxic effect of pulp and leaf hydro-methanolic extracts in comparison with potent acetogenin, Annonacin on DNA of breast cancer (MCF-7) cells using alkaline comet assay. Genotoxic effects were evaluated using single cell gel electrophoresis (SCGE) method and the tail parameters from pooled comets were scored using TriTek CometScore Pro ver. 1.01.44 software. The average tail length (TL), percentage of tail DNA (TD), tail moment (TM) and Olive tail moment (OTM) were calculated which indicates the extent of DNA damage in cells followed by Statistical analysis. Study revealed the highest DNA damage toward MCF-7 cells in the form of comet streak or tails in 0.01 mg/mL Annonacin treatment. While the leaf extracts of A. muricata showed significantly higher tail parameters than the pulp extract in relation to untreated control. Our findings indicated that among the two extracts from A. muricata tested, the leaf exhibited better genotoxic potential compared to pulp extract, however, the plant extracts showed lesser efficacy in comparison with standard annonacin compound. Thus, this study further calls for more methodical safety evaluation and other end-points of genotoxicity apart from DNA damage.
Naik, H.,Kim, G. N.,Schwengner, R.,Kim, K.,Zaman, M.,Yang, S. C.,Shin, S. G.,Kye, Y. -U.,Massarczyk, R.,John, R.,Junghans, A.,Wagner, A.,Goswami, A.,Cho, M. -H. Springer-Verlag 2016 European Physical Journal A Vol.52 No.3
<P>The independent isomeric yield ratios of Zr-89g,Zr-m from the Zr-nat(,xn) reactions and those of Mo-91g,Mo- m and Nb-97g,Nb-m from the Mo-nat(,x) reactions with the bremsstrahlung end-point energy of 45-70 MeV were determined by an off-line -ray spectrometric technique using the 100 MeV electron linac at the Pohang Accelerator Laboratory, Korea. The isomeric yield ratios of Zr-89g,Zr-m and Nb-97g,Nb-m from the Zr-nat(, xn) and Mo-nat(,x) reactions at the bremsstrahlung end-point energy of 16MeV were also determined by the same technique using the 20MeV electron linac at Helmholtz-Zentrum Dresden-Rossendorf, Germany. The measured isomeric yield ratios of Zr-89g,Zr-m, Mo-91g,Mo-m, and Nb-97g,Nb-m were compared with literature data to examine the role of the Giant Dipole Resonance (GDR). The isomeric yield ratios of the Zr-89g,Zr-m, Mo-91g,Mo-m, and Nb-97g,Nb-m from the above reactions were also calculated by using the computer code TALYS 1.6 and compared with the experimental data to examine the validity of the theoretical model for independent isomeric yield ratio calculations.</P>
Naik, Gautam Kumar,Majhi, Sanjit Manohar,Jeong, Kwang-Un,Lee, In-Hwan,Yu, Yeon Tae Elsevier 2019 JOURNAL OF ALLOYS AND COMPOUNDS Vol.771 No.-
<P><B>Abstract</B></P> <P>The current study concerns about the large band gap of TiO<SUB>2</SUB> for its use as photocatalysts. The photocatalytic activity of core-shell structured Au@TiO<SUB>2</SUB> nanoparticles were enhanced by the doping of nitrogen. The nitrogen doping has been done by simple hydrothermal method taking ethylenediamine as the precursor for nitrogen. The crystals structure of TiO<SUB>2</SUB> shell remained unaltered even with the introduction of nitrogen. The photocatalytic activity of the prepared samples were evaluated towards the hydrogen evolution from photocatalytic water splitting under solar light irradiation. It was found that nitrogen doped core-shell structured Au@TiO<SUB>2</SUB> nanoparticles (Au@N-TiO<SUB>2</SUB>) showed higher photocatalytic activity with an average H<SUB>2</SUB> evolution rate of 4880 μmol h<SUP>−1</SUP>g<SUP>−1</SUP>, which is 3.79 times more than that of bare TiO<SUB>2</SUB> in 4 h under xenon light irradiation. The relationship among the other samples was in order of Au@N-TiO<SUB>2</SUB> > Au@TiO<SUB>2</SUB> > N-TiO<SUB>2</SUB> > TiO<SUB>2</SUB>. This enhanced photocatalytic activity of Au@N-TiO<SUB>2</SUB> can be responsible for the formation of an plasmonic photocatalyst and the formation of an impurity band between the conduction band (CB) and the valence band (VB) of TiO<SUB>2</SUB>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nitrogen (N) was doped on the core-shell structured Au@TiO<SUB>2</SUB> nanoparticles. </LI> <LI> N was doped via a low temperature microwave assisted hydrothermal process. </LI> <LI> N doped Au@TiO<SUB>2</SUB> core-shell are highly absorbed in whole of the solar spectrum. </LI> <LI> There was no morphological distortion during N doping. </LI> <LI> Synthesized catalysts are highly efficient for photocatalytic hydrogen evolution. </LI> </UL> </P>
Naik, Ravi,Ban, Hyun Seung,Jang, Kyusic,Kim, Inhyub,Xu, Xuezhen,Harmalkar, Dipesh,Shin, Seong-Ah,Kim, Minkyoung,Kim, Bo-Kyung,Park, Jaehyung,Ku, Bonsu,Oh, Sujin,Won, Misun,Lee, Kyeong American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.20
<P>Previously, we reported a hypoxia-inducible factor (HIF)-1 inhibitor LW6 containing an (aryloxyacetylamino)benzoic acid moiety inhibits malate dehydrogenase 2 (MDH2) using a chemical biology approach. Structure–activity relationship studies on a series of (aryloxyacetylamino)benzoic acids identified selective MDH1, MDH2, and dual inhibitors, which were used to study the relationship between MDH enzyme activity and HIF-1 inhibition. We hypothesized that dual inhibition of MDH1 and MDH2 might be a powerful approach to target cancer metabolism and selected methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)-benzoate (<B>16c</B>) as the most potent dual inhibitor. Kinetic studies revealed that compound <B>16c</B> competitively inhibited MDH1 and MDH2. Compound <B>16c</B> inhibited mitochondrial respiration and hypoxia-induced HIF-1α accumulation. In xenograft assays using HCT116 cells, compound <B>16c</B> demonstrated significant in vivo antitumor efficacy. This finding provides concrete evidence that inhibition of both MDH1 and MDH2 may provide a valuable platform for developing novel therapeutics that target cancer metabolism and tumor growth.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2017/jmcmar.2017.60.issue-20/acs.jmedchem.7b01231/production/images/medium/jm-2017-01231h_0018.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm7b01231'>ACS Electronic Supporting Info</A></P>