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- 저자 : Nadiar Mussin (검색결과 9 건)
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Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo
Nadiar Mussin,오승철,이광웅,박민영,서수인,이남준,김혜영,윤경철,안성우,김효신,홍석균,오동규,서경석 대한의학회 2017 Journal of Korean medical science Vol.32 No.9
We estimated the effect of various immunosuppressants (ISs) and metformin (M) to provide theoretical background of optimal therapeutic strategy for de novo colon cancer after liver transplantation (LT). Three colon cancer cell lines (HT29, SW620, and HCT116) were used in in vitro studies. HT29 was also used in BALB/c-nude mice animal models. Following groups were used in both in vitro and in vivo studies: sirolimus (S), tacrolimus (T), cyclosporin A (CsA), M, metformin/sirolimus (Met/S), metformin/tacrolimus (Met/T), and metformin/cyclosporin A (Met/CsA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed and western blot analyses were performed for mTOR pathway proteins, apoptosis proteins, and epithelial-mesenchymal-transition (EMT) proteins. Tumor volume was measured for 4 weeks after inoculation. MTT-assay revealed significant cell viability inhibition in all 3 colon cancer cell lines in groups of S, M, and Met/S. Of note, group Met/S showed synergistic effect compare to M or S group. Western blot analysis showed significant low levels of all investigated proteins in groups of S and Met/S in both in vitro and in vivo experiment. Tumor growth was significantly inhibited only in the Met/S group. Combination of Met and S showed the most potent inhibition in all colon cancer cell lines. This finding might have application for de novo colon cancer.
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The correlation between preoperative volumetry and real graft weight
Nadiar Mussin,Marco Sumo,Kwang-Woong Lee,YoungRok Choi,Jin Yong Choi,Sung-Woo Ahn,Kyung Chul Yoon,Hyo-Sin Kim,Suk Kyun Hong,Nam-Joon Yi,Kyung-Suk Suh 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.4
Purpose: Liver volumetry is a vital component in living donor liver transplantation to determine an adequate graft volume that meets the metabolic demands of the recipient and at the same time ensures donor safety. Most institutions use preoperative contrast-enhanced CT image-based software programs to estimate graft volume. The objective of this study was to evaluate the accuracy of 2 liver volumetry programs (Rapidia vs. Dr. Liver) in preoperative right liver graft estimation compared with real graft weight. Methods: Data from 215 consecutive right lobe living donors between October 2013 and August 2015 were retrospectively reviewed. One hundred seven patients were enrolled in Rapidia group and 108 patients were included in the Dr. Liver group. Estimated graft volumes generated by both software programs were compared with real graft weight measured during surgery, and further classified into minimal difference (≤15%) and big difference (>15%). Correlation coefficients and degree of difference were determined. Linear regressions were calculated and results depicted as scatterplots. Results: Minimal difference was observed in 69.4% of cases from Dr. Liver group and big difference was seen in 44.9% of cases from Rapidia group (P = 0.035). Linear regression analysis showed positive correlation in both groups (P < 0.01). However, the correlation coefficient was better for the Dr. Liver group (R2 = 0.719), than for the Rapidia group (R2 = 0.688). Conclusion: Dr. Liver can accurately predict right liver graft size better and faster than Rapidia, and can facilitate preoperative planning in living donor liver transplantation.
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( Nadiar Mussin ),( Kwang-woong Lee ),( Hyeyoung Kim ),( Hyoshin Kim ),( Nam-joon Yi ),( Kyung-suk Suh ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Introduction: Accurate pre-operative assessment of graft volume important for donor safety and recipient outcome. Nowadays, there are several clinically available volumetry programs. There has been not so much report to the accuracy of each programs. In this study, we aimed to evaluate the accuracy of two volumetry programs preoperative graft estimation compared with real graft weight. Methods: From October of 2013 to August of 2015, there were performed 274 cases of right living donor liver transplantation SNUH, Seoul, Korea. Among them, 215 patients in whom both preoperative volumetry data and real graft weight information were available were included in this study. We had used ‘Rapidia®’ until April of 2014, and then ‘Dr.Liver®’ has been exclusively used. 107 patients belonged to Rapidia®’ group and another 108 patients belonged to Dr. liver group. Real graft weight was measured during bench surgery. The difference between volumetry and real weight was graded into minimal difference (≤10%) and big difference (>10%). compared the correlation coefficient and degree of difference between two different programs. Results: The correlation coefficients of ‘Rapidia®’ (0.836) was lower than that of ‘Dr.Liver®’(0.868). The cases measured by ‘Rapidia showed minimal difference in 39 cases (38.6%) and big difference in 62 cases (61.4%). However, the cases measured by ‘Dr.Liver showed minimal difference in 59 (54.6%) cases and big difference in 49 (45.4%). ‘Dr.Liver®’ showed significantly more minimal difference than ‘Rapidia®’ (p=0.026). Conclusion: Comparing the results of both programs, ‘Dr.Liver showed better correlation with real graft weight than ‘Rapidia® may be related with the difference of measurement methods between two programs. More precise method to predict real graft weight should be investigated.
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( Nadiar Mussin ),( Seung Cheol Oh ),( Kwang-woong Lee ),( Min Young Park ),( Soo In Seo ),( Nam-joon Yi ),( Hyeyoung Kim ),( Kyung Chul Yoon ),( Sung-woo Ahn ),( Hyo-sin Kim ),( Suk Kyun Hong ),( Don 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Post-transplant de novo malignancy is one of the leading causes of late mortality after liver transplantation (LT). Colon cancer has been reported as one of the frequent de novo cancer in Asia. However, there is no optimal treatment strategy for de novo colon cancer after LT. The objective of this study was to provide theoretical background of optimal immunosuppressant (IS) strategy for de novo colon cancer. Methods: Three colon cancer cell lines (HT29, SW620 and HCT116) were used in in vitro studies. HT29 was also used in BALB/c-nude mice animal models. Following groups were used in both in vitro and in vivo studies: sirolimus (S), tacrolimus (T), cyclosporin A (CsA), metformin (M), metformin/sirolimus (MetS), metformin/tacrolimus (MetT), and metformin/cyclosporin A (Met CsA). 3-(4 5-Dimethylthiazol- 2-yl)-2 5-diphenyltetrazolium bromide (MTT) assay was performed and Western blot analyses were performed for mTOR pathway proteins, apoptosis proteins, and EMT proteins. Tumor volume was measured for 4 weeks after inoculation. Results: MTT-assay revealed significant cell viability inhibition in all three colon cancer cell lines in groups of S, M, and Met/S. Of note, group Met/S showed synergistic effect compare to M or S group. Western blot analysis showed significant low levels of all investigated proteins in groups of S and Met/S in both in vitro and in vivo experiment. Tumor growth was significantly inhibited only in the Met/S group. Conclusions: Combination of Met and S showed the most potent inhibition in all colon cancer cell lines. This finding might have application for de novo colon cancer.
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Myltykbay Rysmakhanov,Asset Yelemessov,Nadiar Mussin,Daulet Yessenbayev,Samat Saparbayev,Bazylbek Zhakiyev,Yerlan Sultangereyev 대한이식학회 2022 Korean Journal of Transplantation Vol.36 No.2
Background: This is the first report on three-dimensional (3D) laparoscopic donor nephrectomy performed in the Central Asian region and Commonwealth of Indepen- dent States countries. This study presents the results of our initial experiences of 3D hand-assisted laparoscopic donor nephrectomy (3D-HALDN) in comparison with the outcomes of two-dimensional hand-assisted laparoscopic donor nephrectomy (2D-HALDN) at a single center. Methods: From 2015 to 2019, 19 3D-HALDN and 19 2D-HALDN procedures were per- formed at the same center by two surgeons. All 38 procedures used identical tech- niques. Between-group differences were considered statistically significant at P<0.05. Results: The baseline characteristics in both groups were statistically comparable (P>0.05). All donors underwent left nephrectomy. Donors who underwent 3D-HALDN had better outcomes than those who underwent 2D-HALDN, as shown by a shorter warm ischemic time (P<0.05), a shorter operative time (P<0.05), and less blood loss (P<0.05). There were no conversions or major complications (according to the Clavien-Dindo classification) in either group. The average drainage duration and postoperative hospital- ization were significantly shorter in the 3D-HALDN group (P<0.05). The between-group differences in the mean postoperative creatinine level and glomerular filtration rate were not significant. Conclusions: The 3D-HALDN approach is more beneficial than traditional 2D-HALDN by providing a shorter warm ischemic time, less blood loss, and shorter durations of drain- age and postoperative hospitalization. Postoperative complications and the functional condition of the kidney in donors in the early and late postoperative periods did not de- pend on the type of laparoscopic donor nephrectomy.
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Undifferentiated embryonal sarcoma of the liver in an adult patient
( Kyu Ho Lee ),( Mussin Nadiar Maratovich ),( Kyoung Bun Lee ) 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.2
Undifferentiated embryonal sarcoma of the liver (UESL) is rare primary hepatic sarcoma and is known to occur in pediatric patients. This case is the UESL occurred in a 51-year old male patient. Multilocular cystic lesion was composed of primitive spindle cells without specific differentiation. This rare case would help to review differential diagnosis of primary sarcoma in liver and cystic neoplasm of the liver. (Clin Mol Hepatol 2016;22:292-295)
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Retrograde reperfusion of renal grafts to reduce ischemic-reperfusion injury
Myltykbay Rysmakhanov,Aibolat Smagulov,Nadiar Mussin,Asset Kaliyev,Bazylbek Zhakiyev,Yerlan Sultangereyev,Gani Kuttymuratov 대한이식학회 2022 Korean Journal of Transplantation Vol.36 No.4
Background: During transplantation, a kidney graft undergoes a cascade of pathological changes, referred to as ischemia-reperfusion injury (IRI), as it is incorporated into the bloodstream. Various studies have reported that retrograde reperfusion (RRP) leads to improved myocardial recovery and could reduce IRI in liver transplantation. This study investigated the effect of RRP in renal transplantation with a focus on reduction of kidney IRI. Methods: Between December 2019 and July 2022, 15 consecutive kidney transplants were performed with retrograde venous reperfusion. To conduct a comparative study and to recruit a control group, 15 kidney transplants that had been performed in the same center by the same two surgeons were retrospectively analyzed. Differences between the two groups were considered statistically significant at P<0.05. Results: The baseline characteristics of the two groups were statistically comparable (P>0.05). The surgical technique for kidney transplantation was the same in both groups. On the first postoperative day, polyuria was less pronounced in the RRP group (P<0.01). Serum creatinine and urea levels and estimated glomerular filtration rates on postoperative days 1, 4, 7, and 30 were lower in the RRP group (P<0.05). Conclusions: Retrograde venous reperfusion of a kidney transplant, preceding antegrade arterial reperfusion, reduced the effects of renal parenchyma IRI. To validate the results of this study, it is necessary to conduct further studies on a larger cohort of patients with a longer follow-up period.
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