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Nguyen-Thach Tung,Man-Van Hung,Xuan-Minh Vo,Thanh-Hai Nguyen,Thi-Minh-Hue Pham 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.2
A novel dosage form integrating solid dispersion(SD) in orally disintegrating tablets (ODTs) wasdeveloped and optimized by the face-centered centralcomposite design to improve poorly soluble property andslow onset action time of felodipine (Fel). SD of Fel andhydroxypropyl methylcellulose E6 was prepared by solventevaporation method. Differential scanning calorimetry andfourier transforms infrared spectroscopy indicated that Feltransformed from crystalline to amorphous state by theformation of hydrogen bond between –N–H in Fel and O–Rin HPMC. The accelerated stability test in 45 C, 75 % RHdemonstrated that the optimized SD was stable in terms ofthe dissolution rate of Fel and thermodynamic property. The ODTs containing SD (Fel:HPMC E6 = 1:3) wereprepared by direct compression technique. The face-centeredcentral composite design with the ODT-SD wasemployed to investigate the effect of mannitol (X1),crospovidone XL (X2) on the ODT-SD disintegration time(Y1), % Fel released after 5 min (Y2) and the ODT-SDfriability (Y3). ANOVA test showed that X2 and X2 * X2had a significant effect on the ODT-SD disintegration time(p\0.05). Meanwhile, the dissolution rate of Fel after5 min did not remarkably depend on any independentvariables (p[0.05). The ODT-SD friability was substantiallyproportional to the amount of mannitol (X1)(p\0.05). The optimized ODT-SD disintegration time, %Fel released after 5 min, and friability were 27.67 s, 88.35and 0.48 %, respectively.
An Approach for Scheduling Problem in Port Container Terminals : Moving and Stacking
HA Phuoc Lan,LE Ba Toan,HUYNH Tuong Nguyen,NGUYEN An Khuong,NGUYEN Van Minh Man 한국인터넷방송통신학회 2015 International Journal of Internet, Broadcasting an Vol.7 No.1
In this study, we consider the transportation problem in port container terminals. It aims to determine positions in yards to place the containers at the adequate times. The containers on ship must be unloaded one by one from top to bottom, and placed in the main yard in order to reduce additional cost required for unnecessary unloading when getting out by customer with given timetable. The cost for transportation at container terminals could be reduced by a new approach in scheduling: move the containers from ship and stack them onto main yard that minimizes cost of yard crane operation when unloading for customer.