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Chi K. Hoang,Cuong H. Le,Dat T. Nguyen,Hang T. N. Tran,Chinh V. Luu,Huong M. Le,Ha T. H. Tran 한국균학회 2023 Mycobiology Vol.51 No.4
Genus Penicillium comprising the most important and extensively studied fungi has beenwell-known as a rich source of secondary metabolites. Our study aimed to analyze andinvestigate biological activities, including in vitro anti-cancer, anti-inflammatory and anti-diabeticproperties, of metabolites from a marine-derived fungus belonging to P. levitum. Thechemical compounds in the culture broth of P. levitum strain N33.2 were extracted withethyl acetate. Followingly, chemical analysis of the extract leaded to the isolation of threeergostane-type steroid components, namely cerevisterol (1), ergosterol peroxide (2), and(3b,5a,22E)-ergosta-6,8(14),22-triene-3,5-diol (3). Among these, (3) was the most potent cytotoxicagainst human cancer cell lines Hep-G2, A549 and MCF-7 with IC50 values of 2.89,18.51, and 16.47 mg/mL, respectively, while the compound (1) showed no significant effectagainst tested cancer cells. Anti-inflammatory properties of purified compounds were evaluatedbased on NO-production in LPS-induced murine RAW264.7 macrophages. As a result,tested compounds performed diverse inhibitory effects on NO production by the macrophages,with the most significant inhibition rate of 81.37 ± 1.35% at 25 mg/mL by the compound(2). Interestingly, compounds (2) and (3) exhibited inhibitory activities againstpancreatic lipase and a-glucosidase enzymes in vitro assays. Our study brought out newdata concerning the chemical properties and biological activities of isolated steroids from aP. levitum fungus.
Tran, N.P.,Park, J.K.,Lee, C.G. IPC Science and Technology Press ; Elsevier Scienc 2009 Enzyme and microbial technology Vol.45 No.4
This study is aimed at identifying the proteins that are up-regulated during astaxanthin accumulation in Haematococcus lacustris. For this H. lacustris cells were cultivated in photobioreactors under normal light irradiance of 40μEm<SUP>-2</SUP>s<SUP>-1</SUP> for 6 days and then induced to accumulate astaxanthin for 3 days further by exposure to continuous high irradiance of 200μEm<SUP>-2</SUP>s<SUP>-1</SUP> with fluorescent lamps as light source after the cells reached the stationary phase in a nitrogen-depleted condition. Under this condition, the average astaxanthin content per cell increased from 91mg/l up to 406mg/l after 3 days of induction. The proteomics data from a two-dimensional electrophoretic comparison demonstrated that a combination of nitrogen source depletion and 1h high light have significantly changed the pattern of protein expression in H. lacustris. A total of 49 protein spots were picked after 1h of stress induction. They consisted of 13 down-regulated proteins and 36 up-regulated proteins. Fifteen proteins which had highly up-regulated expression were further analyzed by matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The results will point toward interesting proteins that can be pursued for further analysis of astaxanthin biosynthesis pathway.
Electronic structure and magnetic properties of BaTi1-xMnxO3
N.V. Dang,N.T. Dang,T.A. Ho,N. Tran,T. L. Phan 한국물리학회 2018 Current Applied Physics Vol.18 No.2
The electronic structure and magnetic properties of polycrystalline BaTi1-xMnxO3 (x ¼ 0e0.1) compounds prepared by solid-state reactions were studied. The results revealed that the increase in Mn content (x) did not change the oxidation numbers of Ba (þ2) and Ti (þ4) in BaTi1-xMnxO3. However, there is the change in Mn valence that Mn3þ,4þ ions coexist in the samples with x ¼ 0.01e0.04 while Mn4þ ions are almost dominant in the samples with x ¼ 0.06e0.1. We also point out that Mn3þ and Mn4þ ions substitute for Ti4þ and prefer locating in the tetragonal and hexagonal BaTiO3 structures, respectively, in which the hexagonal phase constitutes soon as x ¼ 0.01. Particularly, all the samples exhibit roomtemperature ferromagnetism. Ferromagnetic order increases with increasing x from 0 to 0.02, but decreases as x 0.04. We think that ferromagnetism in BaTi1-xMnxO3 is related to lattice defects and/or exchange interactions between Mn3þ and Mn4þ ions.
Evaluation of horizontal and moment bearing capacities of tripod bucket foundations in sand
Tran, N.X.,Hung, L.C.,Kim, S.R. Pergamon Press 2017 Ocean engineering Vol.140 No.-
Bearing capacities of tripod bucket foundations differ from those of single bucket foundations because of the interaction among individual buckets of the tripod. This study analyzed the bearing capacities of tripod bucket foundations in medium and dense sands by performing a series of 3D finite element analyses. The sandy soil was modeled by using an elasto-plastic model following the Mohr-Coulomb failure criterion. The Young's modulus of the sands increased with depth because of the stress-dependency of the modulus. Parametric studies were performed, in which the spacing between each bucket, the embedded depth of the bucket, the bucket diameter, and the magnitude of vertical loading were varied. Results showed that the horizontal bearing capacities of tripod bucket foundations reached the maximum values at a spacing ratio of S/D=1.5 to 3.5 for the foundation with an embedment ratio of L/D=0.5 to 1 (where S is the bucket spacing, D is the bucket diameter, and L is the skirt length of the tripod bucket). However, the moment bearing capacities increased linearly as the S/D ratios increased. Finally, bearing capacity equations were proposed in consideration of bucket spacing, embedment depth, effect of foundation diameter and vertical load, and soil density.
Tran, Bao Ngoc N.,Chen, Austin D.,Kamali, Parisa,Singhal, Dhruv,Lee, Bernard T.,Fukudome, Eugene Y. Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.5
Background Complication rates after flap coverage for pressure ulcers have been high historically. These patients have multiple risk factors associated with poor wound healing and complications including marginal nutritional status, prolonged immobilization, and a high comorbidities index. This study utilizes the National Surgical Quality Improvement Program (NSQIP) to examine perioperative outcomes of flap coverage for pressure ulcers. Methods Data from the NSQIP database (2005-2015) for patient undergoing flap coverage for pressure ulcers was identified. Demographic, perioperative information, and complications were reviewed. One-way analysis of variance and Pearson chi-square were used to assess differences for continuous variables and nominal variables, respectively. Multivariate logistic regression was performed to identify independent risk factors for complications. Results There were 755 cases identified: 365 (48.3%) sacral ulcers, 321 (42.5%) ischial ulcers, and 69 (9.1%) trochanteric ulcers. Most patients were older male, with some degree of dependency, neurosensory impairment, high functional comorbidities score, and American Society of Anesthesiologists class 3 or above. The sacral ulcer group had the highest incidence of septic shock and bleeding, while the trochanteric ulcer group had the highest incidence of superficial surgical site infection. There was an overall complication rate of 25% at 30-day follow-up. There was no statistical difference in overall complication among groups. Total operating time, diabetes, and non-elective case were independent risk factors for overall complications. Conclusions Despite patients with poor baseline functional status, flap coverage for pressure ulcer patients is safe with acceptable postoperative complications. This type of treatment should be considered for properly selected patients.
Tran, Bao Ngoc N.,Chen, Austin D.,Granoff, Melisa D.,Johnson, Anna Rose,Kamali, Parisa,Singhal, Dhruv,Lee, Bernard T.,Fukudome, Eugene Y. Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.4
Background Sternal rigid plate fixation (RPF) has been adopted in recent years in high-risk cases to reduce complications associated with steel wire cerclage, the traditional approach to sternal closure. While sternal RPF has been associated with lower complication rates than wire cerclage, it has its own complication profile that requires evaluation, necessitating a critical examination from a national perspective. This study will report the outcomes and associated risk factors of sternal RPF using a national database. Methods Patients undergoing sternal RPF from 2005 to 2016 in the American College of Surgeons-National Surgical Quality Improvement Program were identified. Demographics, perioperative information, and complication rates were reviewed. Logistic regression analysis was performed to identify risk factors for postoperative complications. Results There were 381 patient cases of RPF identified. The most common complications included bleeding (28.9%), mechanical ventilation >48 hours (16.5%), and reoperation/readmission (15.2%). Top risk factors for complications included dyspnea (odds ratio [OR], 2.672; P<0.001), nonelective procedure (OR, 2.164; P=0.010), congestive heart failure (OR, 2.152; P=0.048), open wound (OR, 1.977; P=0.024), and operating time (OR, 1.005; P<0.001). Conclusions Sternal RPF is associated with increased rates of three primary complications: blood loss requiring transfusion, ventilation >48 hours, and reoperation/readmission, each of which affected over 15% of the study population. Smokers remain at an increased risk for surgical site infection and sternal dehiscence despite RPF's purported benefit to minimize these outcomes. Complications of primary versus delayed sternal RPF are roughly equivalent, but individual patients may perform better with one versus the other based on identified risk factors.
Tran, D. H.,Putri, W. B. K.,Kang, B.,Lee, N. H.,Kang, W. N. American Institute of Physics 2014 Journal of Applied Physics Vol.115 No.16
<P>A close correlation between the nanostructure formations and the thickness dependence of the infield critical current density (J(c)) in GdBa2Cu3O7-delta (GdBCO) films is reported. Pure and 2 wt. % BaSnO3 (BSO)-added GdBCO films with film thicknesses (d) ranging from 0.2 mu m to 1.5 mu m were deposited on SrTiO3 single-crystalline substrates by using a pulsed laser deposition technique. Magnetization data measured at 77K with the magnetic field applied parallel to the c-axis of the films showed the general trend of decreasing in-field J(c) with increasing residual film thickness. The two special inversions, however, were observed at d similar to 0.6 mu m, for which the J(c)'s of both the pure and BSO-added GdBCO films were larger than those of the films with d similar to 0.4 mu m. A sequential ion-milling process and scanning electron microscopy studies were employed to examine the microstructural evolution in the 1.5- mu m-thick GdBCO films. For the pure GdBCO films, nanosized dislocations were observed to start growing at intersections of perpendicularly connected a-axis-oriented grains in a residual film thickness (t) of similar to 0.6 mu m and the growth persisted to the top surface of the 1.5-mu m-thick GdBCO film. For the BSO-added GdBCO films, the density of BSO nanorods was estimated to be decreased versus t with an increase found at t of similar to 0.6 mu m A reason for this inversions of J(c) might be the nanostructure formations at t similar to 0.6 mu m, which were proved to serve as effective pinning centers. (C) 2014 AIP Publishing LLC.</P>