Esophageal Cancer, Gastric Cancer and the use of Pesticides in the Southwestern of Turkey

Yildirim, Mustafa,Kaya, Vildan,Yildiz, Mustafa,Demirpence, Ozlem,Gunduz, Seyda,Dilli, Utku Donem Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: Esophageal and gastric cancer generally have a poor prognosis and may share common risk factors. It has been demonstrated that the pesticide usage may contribute to development of many cancer types. In this study, the relation between amount of pesticides used in agriculture and esophageal and gastric cancer incidence was researched. Materials and Methods: Findings from the data bank of the Ministry of Health Provincial Health Directorate Cancer Records Center between the years of 1998-2010 were used. All patients who were diagnosed with gastric and esophageal cancer histopathologically were included. Data for annual pesticide usage were obtained from Provincial Agriculture Directorate for the same time period. Statistical analysis was performed using the Spearman test. Results: One thousand eight hundred and ninety-six patients were involved in the study, 1,233 males (65%) and 663 females (35%), 230 with esophageal cancer (12.1%) and 1,666 with gastric cancer (87.9%). No statistically significant relation was apparent between pesticide amount used and esophageal cancer (p: 0.87). Conclusions: In our study, there was no relationship between pesticide usage and esophageal or gastric cancer. However, the time between pesticide usage and cancer development was not known, qualifying the comparison.

Prognostic Significance of p53 in Gastric Cancer: a Meta-Analysis

Yildirim, Mustafa,Kaya, Vildan,Demirpence, Ozlem,Gunduz, Seyda,Bozcuk, Hakan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Background: Gastric cancer is one of the frequently seen cancers in the world and it is the second most common reason for death due to cancer. The prognostic role of expression of p53 detected by immunohistochemistry in gastric cancer remains controversial. This meta-analysis aimed to explore any association between overexpression and survival outcomes. Materials and Methods: We systematically searched for studies investigating the relationships between expression of p53 detected by immunohistochemistry and prognosis of gastric cancer patients. Study quality was assessed using the Newcastle-Ottawa Scale. After careful review, survival data were extracted from eligible studies. A meta-analysis was performed to generate combined hazard ratios for overall survival and disease-free survival. Results: A total of 4.330 patients from 21 studies were included in the analysis. Our results showed tissue p53 overexpression in patients with gastric cancer to be associated with poor prognosis in terms of overall survival (HR, 1.610; 95% CI, 1.394 -5.235; p:<0.001). Pooled hazard ratio for disease free survival showed that p53 positivity or negativity were not statitistically significant (HR, 1.219; 95%CI, 0.782-1.899; p:0.382). Conclusions: The present meta-analysis indicated overexpression of p53 detected by immunohistochemistry to be associated with a poor prognosis in patients with gastric cancer.

Tumour Markers in Peritoneal Washing Fluid - Contribution to Cytology

Yildirim, Mustafa,Suren, Dinc,Yildiz, Mustafa,Alikanoglu, Arsenal Sezgin,Kaya, Vildan,Doluoglu, Suleyman Gunhan,Aydin, Ozgur,Yilmaz, Necat,Sezer, Cem,Karaca, Mehmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Background: Peritoneal washing cytology (PWC) that shows the microscopic intra-peritoneal spread of gynaecologic cancers is not used in staging but is known as prognostic factor and effective in planning the intensity of the therapy. False negative or false positive results clearly affect the ability to make the best decision for therapy. In this study we assessed levels of tumour markers, carcinoembryonic antigen (CEA), cancer antigen 125 (CA-125) and carbohydrate antigen (CA19-9), in peritoneal washing fluid to establish any possible contribution to the peritoneal washing cytology in patients operated for gynaecologic cancer. Materials and Methods: Preoperative tumour markers were studied in serum of blood samples obtained from the patients for preoperative evaluation of a gynaecologic operation. In the same group peritoneal tumour markers were studied in the washing fluid obtained for intraoperative cytological evaluation. Results: This study included a total of 94 patients, 62 with malignant and 32 with benign histopathology. The sensitivity of the cytological examination was found to be 21% with a specificity of 100%. When evaluated with CEA the sensitivity of the cytological examination has increased to 37%. Conclusions: In addition to examination of PWC, the level of CEA, a tumour marker, in peritoneal washing fluid can make a diagnostic contribution. Determining the level of CEA in peritoneal washing fluid will be useful in the management of gynaecologic cancers.

Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

Yildirim, Mustafa,Demirpence, Ozlem,Kaya, Vildan,Suren, Dinc,Karaca, Mehmet,Evliyaoglu, Osman,Yilmaz, Necat,Gunduz, Seyda Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Background: Intraperitoneal spread of gynecologic cancers is a major cause of mortality and morbidity and often presents with malignant ascites. Microscopic tumor spread can be demonstrated by a peritoneal wash cytology and help assess the prognosis of the disease. In our study, the roles of paraoxonase and ceruloplasmin, measured in peritoneal washing fluid of patients operated for gynecologic pathologies in differential diagnosis was investigated. Materials and Methods: Patients operated for malign or benign gynecologic pathologies in Antalya Education and Research Hospital Gynecology Clinic between 2010-2012 were included in the study. Samples were obtained during surgery. Results: A statistically significant difference was detected between patients with benign and malign diseases with regards to PON1 levels measured in peritoneal washing fluid (p:0.044), the average values being $64.2{\pm}30.8$ (Range 10.8-187.2) and $41.4{\pm}21.4$ (Range 10.4-95.5), respectively. No significant variation was evident for ceruloplasmin. Conclusions: Paraoxonase levels measured in peritoneal washing fluid may contribute to the differentiation of malign-benign diseases in gynecologic pathologies.

Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey

Yildirim, Mustafa,Karakilinc, Hulya,Yildiz, Mustafa,Kurtoglu, Erdal,Dilli, Utku Donem,Goktas, Sevil,Demirpence, Ozlem,Kaya, Vildan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Background: Non-Hodgkin lymphoma (NHL) is a solid tumour of lymphocytes, important elements in the immune system. According to 2006 data, in Turkey the incidence was 6.5 per 100,000 in males, and 4.4 in females. The relationship between the use of pesticides and development of NHL has been extensively investigated in many studies, and it has been demonstrated that the risk of NHL is increased by exposure to such compounds. Antalya is a region of intensive agricultural activity. In this study, the relationship between the incidence of lymphoma in Antalya and the amount of pesticides employed was investigated. Materials and Methods: The study used data from 1995 to 2010 on the patients from the databank of TR Ministry of Health, Antalya Provincial Health Directorate, Cancer Registration Center and the patients who were histopathologically diagnosed with NHL during these years. Results: The relationship between the amount of pesticide used and the incidence was studied with the Spearman correlation analysis and the p value was found as 0.05. The correlation coefficient was 0.497. An increase in the NHL incidence over the years was identified, with a 2.42-fold increment found from 1995 to 2005 and a 2.77 fold elevation from 1995 to 2010. The use of pesticides increased 1.89 fold over the same period. Conclusions: Our study investigated the relationship of the pesticides used with NHL patients diagnosed during the same year. Since the time elapsing after exposure to pesticides until the development of cancer is not clear, no comparison can be made at present. We believe that the increase in use of pesticides since 1995 may be associated with the increase in the incidence of NHLand therefore that further studies on the issue including measurements of serum pesticide levels, are required.

SOME NOTES ON NEARLY COSYMPLECTIC MANIFOLDS

( MUSTAFA YILDIRIM ),( Selahattin Beyendi ) 호남수학회 2021 호남수학학술지 Vol.43 No.3

In this paper, we study some symmetric and recurrent conditions of nearly cosymplectic manifolds. We prove that Ricci-semisymmetric and Ricci-recurrent nearly cosymplectic manifolds are Einstein and conformal flat nearly cosymplectic manifold is locally isometric to Riemannian product R × N, where N is a nearly Kähler manifold.

Direction-Based Modified Particle Filter for Vehicle Tracking

Mustafa Eren Yildirim,Ibrahim Furkan Ince,Yucel Batu Salman,송종관,박장식,윤병우 한국전자통신연구원 2016 ETRI Journal Vol.38 No.2

This research proposes a modified particle filter to increase the accuracy of vehicle tracking in a noisy and occluded medium. In our proposed method for vehicle tracking, the direction angle of a target vehicle is calculated. The angular difference between the motion direction of the target vehicle and each particle of the particle filter is observed. Particles are filtered and weighted depending on their angular distance to the motion direction. Those particles moving in a direction similar to that of the target vehicle are assigned larger weights; this, in turn, increases their probability in a given likelihood function (part of the process of estimation of a target’s state parameters). The proposed method is compared against a condensation algorithm. Our results show that the proposed method improves the stability of a particle filter tracker and decreases the particle consumption.

A Case Study: Unsupervised Approach for Tourist Profile Analysis by K-means Clustering in Turkey

Mustafa Eren Yildirim,Murat Kaya,Ibrahim Furkan Ince 한국인터넷정보학회 2022 인터넷정보학회논문지 Vol.23 No.1

Data mining is the task of accessing useful information from a large capacity of data. It can also be referred to as searching for correlations that can provide clues about the future in large data warehouses by using computer algorithms. It has been used in the tourism field for marketing, analysis, and business improvement purposes. This study aims to analyze the tourist profile in Turkey through data mining methods. The reason relies behind the selection of Turkey is the fact that Turkey welcomes millions of tourist every year which can be a role model for other touristic countries. In this study, an anonymous and large-scale data set was used under the law on the protection of personal data. The dataset was taken from a leading tourism company that is still active in Turkey. By using the k-means clustering algorithm on this data, key parameters of profiles were obtained and people were clustered into groups according to their characteristics. According to the outcomes, distinguishing characteristics are gathered under three main titles. These are the age of the tourists, the frequency of their vacations and the period between the reservation and the vacation itself. The results obtained show that the frequency of tourist vacations, the time between bookings and vacations, and age are the most important and characteristic parameters for a tourist's profile. Finally, planning future investments, events and campaign packages can make tourism companies more competitive and improve quality of service. For both businesses and tourists, it is advantageous to prepare individual events and offers for the three major groups of tourists.

ON THE SPECTRUM OF THE RHALY OPERATORS ON bv

Yildirim, Mustafa The Youngnam Mathematical Society Korea 2002 East Asian mathematical journal Vol.18 No.1

In this paper, we determine the spectrum of the Rhaly matrix $R_a$ as an operator on the space by, when $lim_n(n+1)a_n{\neq}0$ and exists.

ON THE SPECTRUM OF THE RHALY OPERATORS ON bv₀

Yildirim, Mustafa Korean Mathematical Society 2003 대한수학회논문집 Vol.18 No.4

In 1989, Rhaly [4] determined the spectrum of Rhaly operator $R_{a}$ on the Hilbert space ${\ell}_2$. In this paper Authors determine the spectrum of the Rhaly matrix $R_{a}$ as an operator on the space bvo with assumption $0\;<\;L\;=\;lim_n(n\;+\;1)a_n\;<\;\infty$.