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- 저자 : Mustafa Tahsin Yilmaz (검색결과 1 건)
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Fabrication of Curcumin-loaded Gliadin Electrospun Nanofibrous Structures and Bioactive Properties
Perihan Kubra Akman,Fatih Bozkurt,Mohammed Balubaid,Mustafa Tahsin Yilmaz 한국섬유공학회 2019 Fibers and polymers Vol.20 No.6
In this work, the feasibility and potential of food-grade gliadin nanofiber as a delivery vehicle for curcumin wereinvestigated. By optimizing the electrospinning parameters, homogeneous and fine gliadin nanofibers containing differentamounts of curcumin were fabricated. It was observed that gliadin micro-nanoparticles were gradually transformed to gliadinnanofibers and thicker nanofibers were obtained with the increment of the gliadin concentration. The electrospun nanofiberswere characterized in terms of morphological, molecular, thermal and crystallographic properties. Nanofibers were nearlyuniform with smooth surface characteristics and their average diameter ranged between 258 to 375 nm. Encapsulationefficiency of gliadin nanofibers increased with the increment of curcumin loading, which was also confirmed by X-raydiffraction patterns revealing that the most part of curcumin could be encapsulated in gliadin nanofibers. In vitro assessmentsof nanofibers indicated that the curcumin-loaded gliadin nanofibers showed a controlled release of curcumin and protected itsfree radical scavenging ability. In addition, these nanofibers showed important levels of antibacterial activities againstStaphylococcus aureus and Escherichia coli. Furthermore, the encapsulation of curcumin within nanofibers conspicuouslyenhanced the antioxidant and antibacterial activities of curcumin within these nanofibers. The results suggested that thegliadin nanofiber could be an available carrier for the delivery of curcumin and has the potential for applications in the foodindustry and other bioactive delivery systems.
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