http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Musarat Amina (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Shang, Ke,Amna, Touseef,Amina, Musarat,Al-Musayeib, Nawal M.,Al-Deyab, Salem S.,Hwang, Inho Medknow PublicationsMedia Pvt Ltd 2017 Pharmacognosy magazine Vol.13 No.49
<P><B>Background:</B></P><P>ellular damage initiated by reactive oxygen species (ROS) is the main cause of numerous severe diseases and therefore for this reason, the natural antioxidants have note worthy significance in human health. Capsaicin possesses noteworthy analgesic and anti-inflammatory properties. It also possesses healing effects for treatment of arthritis, diabetic neuropathy, gastric lesions, and cardiac excitability that is why it is incorporated in creams and gels.</P><P><B>Objective:</B></P><P>The present study was carried out to estimate the <I>in vitro</I> antioxidant and ROS scavenging activities of capsaicin against muscle precursor cells. Till date, no investigation has been carried out to study the effect of capsaicin on myoblasts.</P><P><B>Materials and methods:</B></P><P>Herein, the cytotoxicity was induced by endotoxin lipopolysaccharide (LPS) to analyze the effect of capsaicin on LPS induced inflammation and apoptosis on muscle cells. To find out the toxicity of endotoxin, myoblasts were exposed to different concentrations of LPS, viability and morphology was checkedby the means of CCK-8 test and microscopy, respectively. Apoptotic cell death was examined by fluorescence staining. Additionally, LPS-induced apoptosis was determined by mRNAexpression of calpain, caspase-3 and tumor necrosisfactor alpha (TNF-α), and were quantified by qRT-PCR.</P><P><B>Results:</B></P><P>The outcome of the presentstudy demonstrated that LPS stimulation generatestoxicity in dose-dependent manner. Pre-treatmentof myoblasts with capsaicin can considerably alleviate LPS-induced inflammation.</P><P><B>Conclusion:</B></P><P>In conclusion, this study indicates that dietetic supplementation of capsicum may help to alleviate/reduce the inflammatory effects and is therefore potent source of natural antioxidant agent which can be utilized to control muscle related diseases, such as myotube atrophy.</P><P><B>SUMMARY</B></P><P><P>In the present study cytotoxicity was induced by LPS to analyze the effect of capsaicin on LPS induced inflammation and apoptosis on muscle cells.</P><P>The results of this investigation demonstrated that LPS stimulation generates toxicity in dose dependent manner. Pre-treatment of myoblasts with capsaicin can considerably reduce LPS induced inflammation.</P><P>It has been concluded on the basis of results that the dietetic supplementation of capsicum may help to minimize inflammatory effects and are potent sources of natural antioxidants which can be utilized to control muscle related diseases such as atrophy.</P></P> >[FIG OMISSION]</BR><P><B>Abbreviation used:</B> AMP: Adenosine monophosphate, AO/EB: Acridine orange / Ethidium bromide, ATL: T-cell leukemi, CAP: Capsaicin, CCK-8: Cell counting Kit-8, CLSM: Laser Scanning Microscopy, DCF-DA: 2’, 7’-dichlorofluorescein diacetate, DMEM: Dulbecco’s modified Eagle’s medium, DPPH: α, α-diphenyl-β-picrylhydrazyl, FBS: Fetal bovine serum, KA: Kainic acid, LPS: Lipopolysaccharide, MDA: Malondialdehyde, NF-κB: Nuclear factor kgene binding, PBS: Phosphate buffer saline, pNA: p-nitroanilide, RNW: RNase free water, ROS: Reactive oxygen species, TNF-α: Tumor necrosis factor alpha, TRPV1: Transient receptor potential vanilloid 1</P>
-
Hanan M. Al-Youssef,Musarat Amina,Shamshi Hassan,TOUSEEFAMNA,정진원,남기택,김학용 한국고분자학회 2013 Macromolecular Research Vol.21 No.6
This study investigated for the first time the antimicrobial effect of methanolic extract of Grewia mollis Juss (mGM) against Staphylococcus aureus KCCM 11256 (Gram positive) and Escherichia coli KCCM 11234(Gram negative). The minimum inhibitory concentration (MIC) values for each bacterial strain were recorded in a liquid medium. In addition, ultrafine poly(D,L-lactide-co-glycolide) (PLGA) fiber mats containing a methanolic crude extract (7.5 wt%) of Grewia mollis (mGM) were fabricated from the neat PLGA solution by electrospinning. The PLGA ultrafine fiber mat containing mGM were characterized by SEM, FE-SEM, Bio-TEM, TGA, and EDX analyses. Our findings indicate that the incorporation of mGM in the polymer media affected both the morphology and size of the mGM-loaded PLGA ultrafine fibers (UFs). SEM-EDX results confirmed well oriented ultrafine fibers with good incorporation of mGM. Results of the structure characterization indicated that the incorporated mGM interacted strongly with the PLGA matrix and the mechanical properties were effectively improved. Moreover,mGM loaded PLGA ultrafine fiber mats were able to inhibit the growth of the bacterial strains, which indicate that mGM blended PLGA fibers could be used as a potential effective antimicrobial agent for many biomedical applications including wound dressing.
-
Myung Seob Khil,Touseef Amna,Musarat Amina,Mallick Shamshi Hassan,Nawal Musayeib Al Musayeib,Salem Slayyem Salem Al-Deyab 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.11
Pure water is the fundamental requisite for human life. The water has been recycled naturally but not in an adequate amount for consumption. Nanotechnology with extraordinary applications provides competent ways for the decontamination of contaminated water. In the present study MnWO4 nanoflowers endorsed with inherent antibacterial activity were successfully synthesized by facile hydrothermal approach. XRD, SEM, EDX spectroscopy and UVDRS were used to characterize the as-synthesized nanoflowers. Gram negative Escherichia coli ATCC 52922 bacterium was used as model organism to test antibacterial activity of as-synthesized MnWO4 nanoflowers. This study was conducted to optimize minimum concentration of MnWO4 nanoflowers and maximum contact time required to achieve complete inactivation of bacteria present in contaminated water. Minimum inhibitory concentration (MIC) of MnWO4 nanoflowers was found to be 10 μg/ml. The assessment and interpretation of bacterial viability was done using dual fluorescent staining. The synthesized 3D-nanoflowers were found as potent bactericides. Thus, MnWO4 nanoflowers emerged to be very good future material for disinfection of biological pollutants present in the contaminated water reservoirs and as an anti-biofouling agent.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
