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Effect of Oxygen Electrode Response on KL a Measurement
CHANG, HO NAM,Kim, Dong Jin,Young, Murray Moo 한국화학공학회 1990 NICE Vol.8 No.1
A study on the effect of oxygen electrode response on K_La measurement was carried out by simulation. As oxygen electrode response time increases, the estimated K_La decreases when we did not consider the electrode response time. And K_La estimation by slope method is closer to real one than curve fitting method.
Chen Li-Jie,Xu Ya-Li,Bai Feng-Wu,Anderson William A.,Murray Moo-Young The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.2
Using a general Saccharomyces cerevisiae as a model strain, continuous ethanol fermentation was carried out in a stirred tank bioreactor with a working volume of 1,500 mL. Three different gravity media containing glucose of 120, 200 and 280 g/L, respectively, supplemented with 5 g/L yeast extract and 3 g/L peptone, were fed into the fermentor at different dilution rates. Although complete steady states developed for low gravity medium containing 120 g/L glucose, quasi-steady states and oscillations of the fermented parameters, including residual glucose, ethanol and biomass were observed when high gravity medium containing 200 g/L glucose and very high gravity medium containing 280 g/L glucose were fed at the designated dilution rate of $0.027\;h^{-1}$. The observed quasi-steady states that incorporated these steady states, quasi-steady states and oscillations were proposed as these oscillations were of relatively short periods of time and their averages fluctuated up and down almost symmetrically. The continuous kinetic models that combined both the substrate and product inhibitions were developed and correlated for these observed quasi-steady states.
Wanwisa Skolpap,Somboon Nuchprayoon,Jeno M. Scharer,Nurak Grisdanurak,Peter L. Douglas,Murray Moo-Young 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.4
A modified Markov Chain Monte Carlo (MCMC) searching procedure was developed to search for an optimal set of decision variables and optimal feed rate trajectories for recombinant α-amylase expression by Bacillus subtilis ATCC 6051a. The bacterium also synthesizes proteases as undesirable products in fed-batch culture that need to be minimized. To maximize α-amylase productivity, a 14th-order fed-batch model was optimized by integrating Pontryagin’s maximum principle with the Luedeking-Piret equation. The number of iterations and simulations of the proposed searching procedure were statistically examined for accuracy and acceptability of the results. It can be concluded that the proposed searching procedure increased the parameter selection opportunity near the tail ends of redefined triangular distribution. By applying a modified MCMC searching procedure with 1,500 iterations, the predicted α- amylase productivity was improved by 18% in comparison with near-optimum experimental results. This productivity was 3.5% higher than predicted by conventional MCMC optimization.