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A bioinformatic approach to identify pathogenic variants for Stevens-Johnson syndrome
Muhammad Ma'ruf,Justitia Cahyani Fadli,Muhammad Reza Mahendra,Lalu Muhammad Irham,Nanik Sulistyani,Wirawan Adikusuma,Rockie Chong,Abdi Wira Septama Korea Genome Organization 2023 Genomics & informatics Vol.21 No.2
Stevens-Johnson syndrome (SJS) produces a severe hypersensitivity reaction caused by Herpes simplex virus or mycoplasma infection, vaccination, systemic disease, or other agents. Several studies have investigated the genetic susceptibility involved in SJS. To provide further genetic insights into the pathogenesis of SJS, this study prioritized high-impact, SJS-associated pathogenic variants through integrating bioinformatic and population genetic data. First, we identified SJS-associated single nucleotide polymorphisms from the genome-wide association studies catalog, followed by genome annotation with HaploReg and variant validation with Ensembl. Subsequently, expression quantitative trait locus (eQTL) from GTEx identified human genetic variants with differential gene expression across human tissues. Our results indicate that two variants, namely rs2074494 and rs5010528, which are encoded by the HLA-C (human leukocyte antigen C) gene, were found to be differentially expressed in skin. The allele frequencies for rs2074494 and rs5010528 also appear to significantly differ across continents. We highlight the utility of these population-specific HLA-C genetic variants for genetic association studies, and aid in early prognosis and disease treatment of SJS.
The central tendency of the seaport-fulcrum supply chain risk in Indonesia using a rough set
Do. Bagus Muhammad Reza,Hanaoka Shinya 한국해운물류학회 2022 The Asian journal of shipping and Logistics Vol.38 No.4
Seaports are crucial in modern global supply chain networks and systems, exerting a significant impact on the ecological area's economy. Supply chain entities play a substantial integration role, and potential threats at seaports harm chain continuity. This study proposes a rough set-based genetic algorithm, to investigate the central tendency in seaport risk implied by supply chain threats through a questionnaire evaluation. We also employ the risk score to observe the level of clarity in terms of risk probability, showing that the lower the score an attribute obtains, the more likely it is that seaport risk implies supply chain disruption. We deploy 24 risk attributes, which threaten the proposed ten-dimensional factors, based on their risk scores. The results show that the lack of storage risk planning, low punctuality of delivery goods, shortage of port capacity, congestion in waterways, and the lack of distribution risk planning, are the "best five" of the seaport-fulcrum supply chain risk, in the context of Indonesian seaport firms. These identified risk attributes not only assist seaport managers to identify potential risk-associated deficiencies of supply chain disruption but also enhance their ability to determine resilience to manage supply chain problems. © 2022 The Authors. Production and hosting by Elsevier B.V. on behalf of The Korean Association of Shipping and Logistics, Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Salvatrione : A Diterpene-monoterpene Conjugate from Salvia bucharica
Viqar Uddin Ahmad,Muhammad Zahid,Muhammad Shaiq Ali,Amir Reza Jassbi,Shakeel Ahmad,Zulfiqar Ali,Muhammad Zafar Iqbal 한국생약학회 2000 Natural Product Sciences Vol.6 No.2
Salvia bucharica belonging to the family Lamiaceae (Labiatae), afforded a novel terpenoid (1) named as salvatrione. The structure of 1 was elucidated through extensive 2-D NMR experiments and the biogenetic pathway of 1 has also been proposed. On biogenetic grounds, 1 may be considered to be a pseudo-triterpenoid as it is derived from the coupling of mono/diterpenic units and not from squalene.
Shima Shahyad(Shima Shahyad ),Gholam Reza Kheirabadi(Gholam Reza Kheirabadi ),Gila Pirzad Jahromi(Gila Pirzad Jahromi ),Muhammad Massaly(Muhammad Massaly ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Brain-derived neurotrophic factor (BDNF) and high sensitive C-reactive protein (hs-CRP) have been reported to play roles in depression and bipolar disorder (BD). However, the probable discriminatory properties of these biologic markers are less investigated. We aimed to assess the serum BDNF and hs-CRP levels among Iranian patients with major depressive disorder (MDD) and BD during a depressive episode and investigate the optimum cut-off point for differential diagnosis of BD and MDD. Methods: We recruited 30 patients with MDD, 30 with BD in depressive mood and 30 healthy comparators. Blood sample was taken from each participant to measure BDNF and hs-CRP levels. We also used receiver operating characteristic (ROC) curve analysis to find an optimal cut-off point for differentiating MDD from BD according to pre-defined variables. Results: The mean age of total study population was 37.3 ± 5.0 years (males: 49%). BDNF was significantly lower in patients with BD, followed by MDD subjects and healthy controls 541.0 ± 601.0 pg/ml vs. 809.5 ± 433.3 pg/ml vs. 1,482.1 ± 519.8, respectively, p < 0.001). The area under curve of ROC curve analysis for BD versus MDD was 0.704 (95% confidence interval: 0.564−0.844, p = 0.007). We also found that the BDNF cut-off value of 504 could appropriately distinguished BD from MDD (sensitivity: 73%, specificity: 70%). No significant association were identified in terms of hs-CRP levels. Conclusion: Patients suffering from BD had lowest BDNF levels compared to MDD or healthy adults and this biomarker could play a practical role differentiating MDD from BD. Several studies are required confirming our outcomes.
Polyurethane/Polyvinylidene Fluoride Blend Electrospun Nanofiber Web Based Hybrid Tactile Sensor
Reza Mohammad Shamim,Mir Muhammad Fahad,Gajula Prasad,Sellamuthu N. Jaisankar,김갑진,김홍두 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Electrospun polyurethane (PU) nanofiber webs (NFw) having very high amount of nano-sized open cell can be used as a piezo-capacitive sensor due to excellent electrospinnability and very good elastic properties that has been reported in our previous study. In contrast, electrospun PVDF exhibits high β-crystalline phase content and superior piezoelectricity. Consequently, in this study, PU/PVDF blends under controlled compositions were electrospun to obtain PU/PVDF hybrid NFw. These hybrid sensors are capable of measuring piezocapacitive properties as well as simultaneously piezoelectric properties. Moreover, AgNO₃ was added into PVDF e-spun solution which acts as Ag-NPs in PVDF NFw to get enhanced piezoelectric performance of the hybrid sensor. Around 25% addition of PVDF into PU solution in the presence of Ag-NPs greatly enhance the peak-to-peak piezoelectric output voltage (Vp-p) along with 4.2% hysteresis and pressure-capacitance change of over 55 pF.
Coordination of Active Front Steering and Direct Yaw Control Systems Using MIMO Sliding Mode Control
Ebrahim Muhammad,Ahmad Reza Vali,Abdorreza Kashaninia,Vahid Behnamgol 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.1
This paper investigates an integrated multi-input multi-output (MIMO) sliding mode control strategy to coordinate the active front steering (AFS) and direct yaw control (DYC) system of a vehicle. The proposed control method aims to enhance the lateral dynamics of the vehicle, especially in the presence of tire-road friction coefficient variations as parameter uncertainties. The proposed integrated control strategy consists of two control layers. The upper layer coordinates the AFS and DYC systems and produces the corrective yaw moment and additive front steering angle. At the lower layer, the slip controller based on sliding mode control (SMC) converts the yaw moment into the desired longitudinal slip and generates the final distributed braking torques. Simulations of two scenarios in various road conditions were conducted to ensure that the proposed control is robust against road condition changes in the proposed method. Results from the simulation during the J-turn maneuver on the slippery road compared the performance of the suggested sliding mode integrated controller with an adaptive integrated controller. The simulation results showed that the proposed control system improved the stability and handling of the system’s tracking performance in various maneuvers.
Mir Muhammad Fahad,Mohammad Shamim Reza,Gajula Prasad,Sellamuthu N. Jaisankar,Kap-Jin Kim,HongDooKim 한국섬유공학회 2022 Fibers and polymers Vol.23 No.6
In this research, the triboelectric sensors are fabricated using a facile stacking of nonwoven thermoplasticpolyurethane (TPUnw) and as-spun thermoplastic polyurethane nanofiber web (TPUnf) with nonwoven polypropylene (PP),and as-cast silicone elastomer. The triboelectric output voltage of the sensor is examined by applying a periodic dynamicmechanical load ranging from 0.1 to1 kgf at a constant frequency of 1 Hz. Among the combinations, the TPUnw (3.3 V)gives almost 4 times higher peak-to-peak voltage (Vp-p) than TPUnf (0.9 V) with a given nonwoven PP fabric. Similarly, withas-cast rough silicone elastomer, the TPUnw (10.1 V) gives 20 % increase of Vp-p compared with TPUnf (7.9 V). From theabove results, we can conclude that the nonwoven TPU generates larger triboelectric voltages than the electrospun TPUnanoweb and it may be due to the higher roughness of the former than the latter. Compared to nonwoven PP, the roughsurface silicone elastomer (Si) gives almost 3 times larger Vp-p with TPUnw. The combinative effect of triboelectric polarityand surface roughness plays a significant role in the enhancement of Vp-p in Si combination rather than PP. In addition to this,the potential applications of physiological vital signs (respiration and heartbeat rate) and movements of a human areexamined during polysomnographic (PSG) measurement with TPUnw-PP senor using a BIOPAC MP150 data acquisitionsystem in conjunction with a signal conditioner. During PSG measurement, the heartbeat and respiration at four differentpositions are successfully measured. Apneic events and disruptive body movements were also easily observed.
Mir Muhammad Fahad,Reza Mohammad Shamim,Gajula Prasad,Sellamuthu N. Jaisankar,김갑진,김홍두 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Nonwoven flexible textile materials thermoplastic polyurethane (TPU) and polypropylene (PP) were used to fabricate a self-powered triboelectric pressure sensor which effectively determined the heartbeat and respiration rate of a human subject. TPU and PP intrinsically owns opposite triboelectric polarity and nonwoven construction of the material accelerated the efficiency of the sensor. The sensor exhibited significant amount of output voltage. Peak to peak voltage (Vp-p) of around 3.3 V was obtained from prototype sensor using custom-made dynamic tester under periodic external load of 0.1~1.0 kgf. Physiological sensor successfully converted human body generated low frequency physio-mechanical vibrations into electrical signal which was received through Piezo Film Lab Amplifier equipped with BIOPAC MP150. From recorded signal, convoluted respiration and heartbeat frequencies were isolated and evaluated.
EFFECT OF ALR ON THE ATOMIZATION CHARACTERISTICS OF A PRE-FILMING AIRBLAST ATOMIZER
Mir Muhammad Tareq,Reza Alidoost Dafsari,Seungchae Jung,Jeekeun Lee 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11
Various atomizing devices have been developed for application to gas turbine combustors in order to improve combustion stability and to meet enforced environmental regulations. In this study, atomization characteristics of a prefilming airblast nozzle were experimentally evaluated with ALR (ratio of air to liquid), air pressure difference (ΔP (%)) and liquid properties. The initial sheet thickness formed on a pre-filmer of the nozzle was 550 ㎛, and swirling air flow generated from two swirlers having opposite rotational directions acts inside and outside the liquid sheet. Experiment was carried out at room temperature (20℃) and ambient pressure and Jet A-1 aviation fuel was used as the working fluids. PDPA system was applied to measure drop size and velocity simultaneously. CCD Imaging was used for investigating secondary atomization characteristics of the spray. Spray characteristics such as spray cone angle, mean droplet size, flow behavior for both fluids were measured and compared with ALR and air pressure difference ΔP (%).