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RISS 인기검색어
- 검색키워드
- 저자 : Mohammad Zubair Alam (검색결과 2 건)
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Shatha Salem Hameed,M‑Zaki Mustafa ElAssouli,Ahmed M. Al-Hejin,Mohammad Zubair Alam,Sufian Mohamad ElAssouli,Faten Zubair Filimban 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.4
Traditional herbal medicines have been part of human healthcare systems since ancient times. The studies on herbal medicines have mainly focused on their beneficial aspects and hence their harmful effects have been usually overlooked. Throughout Middle East and South Asia, Rhazya stricta Decne. and Thymus vulgaris L. are used as traditional medicines for various diseases. We evaluated R. stricta and T. vulgaris aqueous extracts for their genotoxicity and mutagenicity through comet assay and Ames Salmonella mutagenicity test respectively. An overall treatment effect (p < 0.0001) showed higher genotoxicity of T. vulgaris extract indicated by increased tail moments in comet assay compared to the extract of R. stricta and the combined extract. Further, an overall dose effect (p < 0.0001) showed higher genotoxicity at 1 mg/ml which further increased at 5 mg/ml doses of the extracts compared to 0 mg/ml. The genotoxicity did not show any further increase at 10 mg/ml. The extracts were also tested for their mutagenicity through Ames Salmonella test. R. stricta and T. vulgaris were not mutagenic to TA100 and TA98 when extracts tested separately. However, combined extracts of R. stricta and T. vulgaris was weakly mutagenic to TA98 with number of revertants 92 ± 8 at the highest concentration tested. This study implies that the herbal medicines should be used cautiously as they may cause long term harmful effects along with the intended beneficial activity.
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Abdularahman B.O. Mohamed,Salwa Ibrahim Hindawi,Sameer Al-harthi,Qamre Alam,Mohammad Zubair Alam,Absarul Haque,Waseem Ahmad,Ghazi A Damanhouri 대한혈액학회 2016 Blood Research Vol.51 No.4
BackgroundCharacterization of the ABO blood group at the phenotype and genotype levels is clinically essential for transfusion, forensics, and population studies. This study elucidated ABO phenotypes and genotypes, and performed an evaluation of their distribution in in-dividuals from the western region of Saudi Arabia.MethodsOne-hundred and seven samples underwent standard serological techniques for ABO blood group phenotype analysis. ABO alleles and genotypes were identified using multi-plex polymerase chain reaction, and electrophoretic analysis was performed to evaluate the highly polymorphic ABO locus.ResultsA phenotype distribution of 37.4%, 30.8%, 24.3%, and 7.5% was found for blood groups O, A, B, and AB respectively in our study cohort. Genotype analysis identified 10 genotype combinations with the O01/O02 and A102/O02 genotypes being the most frequent with frequencies of 33.6% and 14.95%, respectively. Common genotypes such as A101/A101, A101/A102, A101/B101, B101/B101, and O01/O01 were not detected. Similarly, the rare genotypes, cis-AB01/O02, cis-AB01/O01, and cis-AB01/A102 were not found in our cohort. The most frequently observed allele was O02 (35.98%) followed by the A102 allele (17.76%). Furthermore, our findings are discussed in reference to ABO allele and geno-type frequencies found in other ethnic groups.ConclusionThe study has a significant implication on the management of blood bank and transfusion services in Saudi Arabian patients.
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