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- 저자 : Mohammad Shamim Gazi (검색결과 1 건)
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Antidiarrheal Efficacy of Probiotic Bacteria in Castor Oil Induced Diarrheal Mice
Pallob Barai,Khondoker Moazzem Hossain,Sana Mohammad Mahbubur Rahman,Mohammad Faysal Al Mazid,Mohammad Shamim Gazi 한국식품영양과학회 2018 Preventive Nutrition and Food Science Vol.23 No.4
Probiotics may offer a safe intervention for diarrheal diseases. The aim of the present study was the assessment of the antidiarrheal property of probiotic bacteria. For their antidiarrheal efficacy assessment, yogurt was prepared using the isolated bacteria from selective regional yogurt of Bangladesh, and mice model trails were conducted using castor oil induced diarrheal mice. The probiotic treatment was applied on three mice groups, each having 6 mice and their respective doses were 50 mL/kg body weight in treatment group (TG) 1, 100 mL/kg body weight in TG2, and 150 mL/kg body weight in TG3. A four week treatment of probiotic significantly (P<0.001) reduced the percentage (67.37%) of diarrhea in TG3 (150 mL yogurt/kg body weight). All the treatment groups showed a significant (P<0.001) increase in the latent periods, reduced the total fecal output, and frequency and fecal water content compared to the negative control group. Serum electrolytes (Na<SUP>+</SUP> and K<SUP>+</SUP>) and total protein levels were higher in the TG3 compared to the negative control group. Further research regarding molecular characterization and identification of specific genes and proteins of interest may help to develop the next generation bacteriocins and antidiarrheal drugs.
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