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Mohammad Reza Nasri Nasrabadi,Seyed Hadi Razavi 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.4
In an attempt to accumulate lycopene in the bacterium Dietzia natronolimnaea HS-1 cultured in beet molasses, the influence of lycopene cyclase inhibitors on carotenogenesis (within the range 0-60 ppm) were evaluated. All inhibitors blocked the biosynthesis of canthaxanthin and resulted in accumulation of lycopene as the predominant carotenoid. As the final step of a study aiming at the optimization of culture conditions, a central composite design to a fed-batch process was applied to optimize the concentrations of lycopene cyclase inhibitors (within the range 0-50 ppm) in order to achieve high level accumulation of lycopene from D. natronolimnaea HS-1cultured in beet molasses. On the basis of this approach,the optimum concentrations of lycopene cyclase inhibitors required to achieve the highest level of lycopene accumulation (8.26±0.17 mg/L) were determined as follows: imidazole,24.74 ppm; nicotinic acid, 28 ppm; piperidine, 24.05 ppm;pyridine, 27.6 ppm; and triethylamine, 23.22 ppm.
Mohammad Reza Nasri Nasrabadi,Seyed Hadi Razavi 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.2
The present work investigated on carotenogenesis with high β-carotene content by a new isolated highactivity strain-producer Rhodotorula acheniorum mutant MRN in cheese whey ultrafiltrate. After a serial of UV,ethymethanesurfonate (EMS), and nitrosoguanidine (NTG)mutagenesis, a mutant named MRN of the red lactosepositive yeast strain R. acheniorum was obtained. Then, the effects of different growth medium factors on carotenoid production by this mutant at batch-scale level were identified and optimized by means of response surface methodology (RSM) in order to achieve high-level production of β-carotene. The optimum conditions required to achieve the highest level of β-carotene (262.12±1.01mg/L) were determined as follows: whey ultrafiltrate (WU)lactose concentration 55 g/L, pH 5.85, ammonium sulfate concentration 3.5 g/L, temperature 23^oC, and aeration rate 1.56 vvm. The medium optimization resulted in a 6.45-fold increase in volumetric production (262.12±1.01 mg/L) and a 4.62-fold increase in the cellular accumulation (10.69±0.19 mg/g) of β-carotene.
Omid Fakheran,Reza Birang,Patrick R. Schmidlin,Sayed Mohammad Razavi,Parichehr Behfarnia 한국생체재료학회 2019 생체재료학회지 Vol.23 No.3
Objectives: Retro MTA is a fast setting Calcium silicate cement used in endodontic regeneration procedures in recent years. Beta-tricalcium phosphate (β-TCP) is another common biomaterial used for bone augmentation procedures. The present pilot study was undertaken to evaluate and compare the efficacy of Retro MTA and a mixture of Retro MTA / β-TCP for periodontal tissue regeneration. Materials and methods: In 4 beagle dogs, periodontal dehiscence type defects were created. In each side, one dehiscence defect was left empty as a control site and three treatment modalities were randomly applied for the others: Retro MTA covered with a collagen membrane, Retro MTA + β-TCP covered with a membrane and covering the defect with a membrane without any bone augmentation. After 8 weeks Animals were sacrificed and Histomorphometric and histologic analysis were conducted. Results: Histologic analysis showed more cementum formation for both Retro MTA+ β-TCP (3.74 ± 0.34 mm) and Retro MTA group (3.24 ± 0.56 mm) compared to control group 1 (1. 15 ± 0.45 mm) and control group 2 (0.78 ± 0.65 mm). Formation of newly formed bone and cementum in the experimental groups were significantly higher as compared to the control groups (P < 0.0001). Conclusions: Retro MTA or Retro MTA+ β-TCP covered with a collagen membrane resulted in regeneration of periodontal tissues. However, Retro MTA+ β-TCP showed tendency towards better results than the use of Retro MTA alone.
Synthesize of V4AlC3 Based MAX Phase Composites by Reactive Spark Plasma Sintering of V2O5:Al:C
Leila Sadeghi,Mansour Razavi,Mohammad Mahdi Kalantarian,Mohammad Reza Rahimipour,Mohsen Hossein‑Zadeh 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.12
In this research V4AlC3based composites were synthesized by reactive spark plasma sintering (RSPS) method. V2O5:Al:Cstarting materials with molar ratios of 1:6:1.5 and 1:7:1.5 were heat treated at 1400 °C. Final composition, microstructural,physical, mechanical and tribological properties of the prepared composites were compared. The X-ray diffraction analysisresults showed that the formation of V4AlC3as main phase alongside Al2O3and V2AlCby-products. Increasing the Al contentfrom 6 moles to 7 moles led to formation of VC0.845and Al2O3main phases as well as V4AlC3and V2AlCminor phases in thissample due to extraction of Al from die during RSPS operation. Microstructural studies revealed that the uniform distributionof the phases with low amount of porosities. The layered microstructure of the composites confirmed the formation ofMAX phases. Higher bending strength and is achieved for the synthesized composite prepared by 7 moles Al (490 ± 5 MPa)than the composite prepared with 6 moles Al (375 ± 11 MPa). The composite prepared with 7 moles Al also exhibited lowerwear rate (3.7 × 10− 5 mm3/Nm) than that of prepared with 6 moles Al (2.4 × 10− 4 mm3/Nm). Microstructural studies of theworn surfaces indicated that tribo oxidation is dominant mechanism for both fabricated composites.