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Miran K. Rakha,Zohour I. Nabil,Aida A. Hussein 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
Induction of hyperadrenergic activity was experimentally achieved in urethane-anesthetized rats using epi-nephrine (adrenaline). Acute administration of epinephrine (100 .g/kg) for 2 hours induced several cardiac disorders and va-somotor dysfunction. Pretreatment with natural wild honey (5 g/kg) for 1 hour prior to the injection with epinephrine (100.g/kg) protected the anesthetized normal rats from the incidence of epinephrine-induced cardiac disorders and vasomotor dys-function. Moreover, posttreatment with natural wild honey (5 g/kg) following the injection with epinephrine (100 .g/kg) for1 hour showed several ameliorative outcomes to the electrocardiographic parameters and vasomotor dysfunction of anes-thetized stressed rats. Furthermore, natural wild honey preserved the positive inotropic effect of epinephrine in both cases.Also, the total antioxidant capacity (AOC) of natural wild honey was found to be very pronounced. Levels of both reducedglutathione and ascorbic acid (vitamin C) were considered relatively high in natural wild honey. Activity of superoxide dis-mutase (SOD) was also high, whereas catalase activity was relatively low, especially when compared to the value of SODactivity. It would appear from the results of the present study that natural wild honey may exert its cardioprotective and ther-apeutic effects against epinephrine-induced cardiac disorders and vasomotor dysfunction directly, via its very pronounced to-tal AOC and its great wealth of both enzymatic and nonenzymatic antioxidants involved in cardiovascular defense mecha-nisms, besides its substantial quantities of mineral elements such as magnesium, sodium, and chlorine, and/or indirectly, viathe enhancement of the endothelium-derived relaxing factor nitric oxide release through the influence of ascorbic acid (vita-min C).