http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Gene regulation by glucocorticoid in ENaC-mediated Na? transport by middle ear epithelial cells.
Kim, Bo G,Kim, Jin Y,Kim, Minbum,Kim, Chang-Hoon,Choi, Jae Y,Kim, Sung H Triological Foundation [etc.] 2014 The Laryngoscope Vol.124 No.2
<P>The epithelial sodium channel (ENaC) is a Na(+) transport channel located in the apical membrane of the human middle ear epithelium. Although ENaC-mediated sodium transport has been reported to be upregulated by dexamethasone in human middle ear epithelium, there has been no study of the downstream pathways for increased ENaC expression mediated by glucocorticoids in this tissue. We investigated the effect of dexamethasone on the expression of ENaC and glucocorticoid regulatory genes for ENaC expression in human middle ear epithelial cells (HMEECs).</P>
Vestibular Function Change in a Vasopressin-Induced Hydrops Model
Kim, Minbum,Kim, Kyu-Sung by Otology Neurotology, Inc. Image copyright © 2017 Otology & neurotology Vol.38 No.10
HYPOTHESIS:: A vasopressin-induced endoymphatic hydrops model can represent an acute vertiginous attack in Menière’s disease (MD). BACKGROUND:: Previous animal models are not appropriate to evaluate the efficacy of new treatments for hydrops because they cannot represent an acute attack of MD. Recently, a new dynamic model was introduced for acute hydrops exacerbation using the vasopressin type 2 receptor agonist, desmopressin (1-deamino-8-D-Arginine vasopressin, VP); however, resulting changes in vestibular function have not been investigated. METHODS:: A total of 37 guinea pigs were used. Two to 4 weeks after surgical ablation of endolymphatic sacs in 33 guinea pigs, acute exacerbation of hydrops was induced by a single VP injection in 18 animals (group A). Next, two VP injections at 1 hour interval were administered to investigate the effect of multiple VP doses on vestibular function in the other 15 animals (group B). In the remaining four animals, VP was injected without surgery for the control group (control). Bidirectional sinusoidal harmonic acceleration (SHA) tests of vestibular function were performed. “Type I response” was defined as when the maximum slow-phase velocity (SPV) during left rotation (toward the operated ear) was lower than that during right rotation (toward the normal ear). In contrast, “Type II response” was defined as when maximum SPV at the left rotation was higher than that at the right rotation. Vestibular symmetry scores were analyzed at baseline and after each of two VP injections given 1 hour apart. RESULTS:: Vestibular symmetry scores increased at 1 hour after VP injection in all 18 animals in group A (p < 0.001). Two hours after VP injection, symmetry score decreased to the initial score. Two different types of vestibular response were observed after VP. However, the symmetry scores between type I and II responses were not significantly different (p = 0.173). In all 15 animals of Group B, vestibular asymmetry was sustained over 3 hours when two VP injections were given 1 hour apart. In three of Group B, the type of vestibular response changed from type II response to type I response after the 2nd VP injection; however, no animal demonstrated a shift from type I to type II response. CONCLUSION:: VP can transiently induce an acute exacerbation of hydrops and asymmetric vestibular dysfunction in guinea pigs. This model could help in studying new treatments for acute hydrops and in explaining the mechanism of bidirectional nystagmus in MD.
자발 하향안진 및 보행장애를 동반한 아놀드-키아리 기형
Minbum Kim,Youn Jin Cho 대한평형의학회 2023 Research in Vestibular Science Vol.22 No.4
Arnold Chiari malformation is a disease which is characterized by herniation of a portion of the cerebellum through the foramen magnum. Symptoms vary depending on the extent of the affected area, including posterior neck pain, upper limb pain, paralysis, paresthesia, weakness, dizziness, and ataxia. Among the patients presenting with dizziness, nystagmus is frequently observed, which is primarily characterized by down-beating nystagmus. We experienced a 42- years-old female patient presented with vertigo and gait disturbance, who were diagnosed with type 1 Arnold-Chiari malformation and treated by surgical decompression.
Jong Sei Kim,Minbum Kim 대한평형의학회 2023 Research in Vestibular Science Vol.22 No.3
During the treatment process for benign paroxysmal positional vertigo (BPPV) using the canalith repositioning procedure, the otolith can inadvertently enter the semicircular canal instead of the utricle. Canal conversion refers to the situation where the otolith enters a different semicircular canal, while reentry occurs when the otolith returns to the same semicircular canal. The occurrence of a canal conversion can complicate the accurate diagnosis and treatment of BPPV, potentially leading to misdiagnosis and unsuccessful results in the canalith repositioning procedure. In this review, we aim to summarize the incidence, clinical features, and associated risk factors of canal conversion and reentries.
Bonebridge Implantation for Conductive Hearing Loss in a Patient with Oval Window Atresia
AVES Publishing Co. 2015 The journal of international advanced otology Vol.11 No.2
<P>The occurrence of oval window atresia is a rare anomaly with conductive hearing loss. Traditional atresia surgeries involve challenging surgical techniques with risks of irreversible inner ear damage. Recent reports on Bonebridge (Medel, Innsbruck, Austria), a novel implantable bone conduction hearing aid system, assert that the device is safe and effective for conductive hearing loss. We present a case of Bonebridge implantation in an eight-year-old girl with bilateral oval window atresia.</P>
Jeong, Junhui,Kim, Minbum,Heo, Ji Hye,Bang, Mi-Young,Bae, Mi Ran,Kim, Jungmin,Choi, Jae Young Lippincott Williams Wilkins 2015 Otology & Neurotology Vol.36 No.2
OBJECTIVE: Perimodiolar electrode arrays were developed to improve stimulation of specific neuronal populations and to decrease power consumption; however, they can damage the cochlear structure. We examined and compared psychophysical parameters of perimodiolar and lateral-type electrode arrays in patients who received a different type of bilateral cochlear implant (CI) in each ear. STUDY DESIGN: Retrospective analysis. SETTING: Tertiary referral center. PATIENTS: Eight child patients (three males, five females) received a different CI in each ear (perimodiolar array and lateral array). They received the CIs sequentially (n = 7) or simultaneously (n = 1). INTERVENTIONS: Diagnostic, therapeutic, and rehabilitative. MAIN OUTCOME MEASURES: Electrically evoked compound action potential, threshold level, comfort level, and dynamic range (DR) of the basal, mid, and apical electrodes were compared. We also surveyed battery consumption for each device. RESULTS: Electrically evoked compound action potential threshold, threshold level, and comfort level were lower for the perimodiolar-type electrode array than for the lateral-type electrode array in most patients. However, the DR for the perimodiolar array was narrower than for the lateral array. For most patients, there was little difference in battery life. CONCLUSION: Although the level of electrical energy required for auditory stimulation seems to be lower for the perimodiolar electrode array than for the laterally placed array, the DR was wider and the amount of battery consumption was similar. The electrode array should be chosen by considering various patient factors, such as residual hearing.
상보 필터를 이용한 사용자 상체 기울기 인식 전동 휠체어 설계 및 제작
전소율(Soyul Jeon),염혜경(Heykyung Yeom),최민범(Minbum Choi),김민구(Mingu Kim) 제어로봇시스템학회 2022 제어·로봇·시스템학회 논문지 Vol.28 No.1
Most power wheelchairs have been designed to be operated using a joystick. Power wheelchairs with joystick controls can assist elderly persons to improve their mobility. However, persons with hand disabilities cannot control a power wheelchair using a joystick. This paper proposes a power wheelchair operated by a user’s upper-body tilt information obtained from a gyro sensor and an accelerometer. In this study, a complementary filter is used to estimate a user’s upper-body tilt. Since the developed power wheelchair can be operated without a joystick, it is expected that elderly persons or persons with hand disabilities will find it simple to use. Experiments are performed to demonstrate the performance of the developed power wheelchair.
Cho, Jaehyun,Iftiquar, S. M.,Kim, Minbum,Park, JinJoo,Jung, Junhee,Kim, Jiwoong,Yi, Junsin American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.5
<P>Intrinsic hydrogenated amorphous silicon-germanium (a-SiGe: H) alloy is generally used in the bottom cell because of its low band gap. The a-SiGe: H has a higher photo conductivity in comparison to the a-Si: H; thus, it is expected that the a-SiGe: H can show better short circuit current density than that of the a-Si: H based solar cell. Therefore, we optimized a-SiGe: H active layer that can be a suitable choice for the front cell of a multi junction solar cell. Furthermore, we carried out a comparative study of the solar cells that have a-SiGe: H and a-Si: H as respective active layers. The a-SiGe: H based solar cells show higher short circuit current density, while the a-Si: H based cells show higher open circuit voltage. The current-voltage characteristics of these cells are as follows: (a) V-oc = 770 mV, J(sc) = 15.0 mA/cm(2), FF = 64.5%, and eta = 7.47% for a-SiGe:H based cell; and (b) V-oc = 826 mV, J(sc) = 13.63 mA/cm(2), FF = 72.0%, and eta = 8.1% for a-Si: H based cell.</P>