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Gerstmann-SträusslerScheinker Disease: A Case Report
Minji Shin,Donghyun Kim,Young Jin Heo,Jin Wook Baek,Suyoung Yun,Hae Woong Jeong 대한영상의학회 2023 대한영상의학회지 Vol.84 No.3
Gerstmann-Sträussler-Scheinker (GSS) disease is a rare hereditary prion disease which is clinically characterized by a progressive cerebellar ataxia followed by cognitive impairment. We report a rare case of GSS disease in a 39-year-old male patient who complained of a progressive gait disturbance followed by dysarthria with cognitive impairment, after five months from the onset of initial symptom. His brain MRI scan revealed multifocal symmetric diffusion restricted lesions with T2/FLAIR hyperintensities in bilateral cerebral cortices, basal ganglia, and thalami. His family members also manifested similar symptoms in their 40–50s, suggesting the possibility of a genetic disease. Finally, he was genetically diagnosed with GSS disease by real-time quaking-induced conversion and prion protein (PRNP) gene sequencing test.
Isolated Intracranial Rosai–Dorfman Disease Mimicking Meningioma: A Case Report
Shin Minji,Heo Young Jin,Kim Donghyun,Jeong Hae Woong,Baek Jin Wook,Park Ha Young 대한영상의학회 2022 대한영상의학회지 Vol.83 No.3
Rosai–Dorfman Disease (RDD) is a rare lymphoproliferative disease, and the occurrence of isolated intracranial RDD is extremely rare. Most cases of intracranial RDDs present as dural masses showing homogenous enhancement on MRI, which makes it difficult to differentiate these masses from meningiomas before surgery unless massive cervical lymphadenopathy is observed. We herein report a rare case of isolated intracranial RDD in a 65-year-old male. Brain MRI revealed a well-defined enhancing mass-like lesion involving the right frontal convexity and subtle diffusion restriction. However, only a subtle blush was observed on the preoperative cerebral angiogram. Although instances of isolated intracranial RDD are rare, it should be considered as a potential differential diagnosis when a dural mass with hypovascularity is visualized on the cerebral angiogram.
Immunogenic cell death in cancer immunotherapy
( Minji Choi ),( Jisoo Shin ),( Chae-eun Lee ),( Joo-yoon Chung ),( Minji Kim ),( Xiuwen Yan ),( Wen-hao Yang ),( Jong-ho Cha ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.5
Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment, with notable therapeutic effects on certain cancer types. Despite their significant potential, clinical studies over the past decade have revealed that cancer immunotherapy has low response rates in the majority of solid tumors. One of the key causes for poor responses is known to be the relatively low immunogenicity of solid tumors. Because most solid tumors are immune desert ‘cold tumors’ with antitumor immunity blocked from the onset of innate immunity, combination therapies that combine validated T-based therapies with approaches that can increase tumor-immunogenicity are being considered as relevant therapeutic options. This review paper focuses on immunogenic cell death (ICD) as a way of enhancing immunogenicity in tumor tissues. We will thoroughly review how ICDs such as necroptosis, pyroptosis, and ferroptosis can improve anti-tumor immunity and outline clinical trials targeting ICD. Finally, we will discuss the potential of ICD inducers as an adjuvant for cancer immunotherapy. [BMB Reports 2023; 56(5): 275-286]
신 기후변화 시나리오 SSP에 근거한 남한의 여름배추 재배지 변동 예측
신민지(Minji Shin),이성은(Seong Eung Lee),문경환(Kyung Hwan Moon) 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
신 기후변화 시나리오 SSP5-8.5에 따르면 연평균기온은 현재 대비 미래 전반기에 +1.8°C(±0.1°C) 상승하며, 기온의 상승 추세가 강해지는 미래 후반기에는 +7.3°C(±0.4°C) 상승할 것으로 전망되고 있다. 남한은 이미 여름배추를 재배하기 적합한 지역이 급감할 것으로 예측되고 있으나, 온실가스 배출 정도의 영향이 포함된 SSP 시나리오를 적용하여 구체적인 재배지 변동과 면적을 예측할 필요성이 있다. 관측값 기반의 현재 평년과 미래전망 자료의 10년 단위 월별 기후 평균값 분포를 남한 전역에 대해 30~270m 해상도로 추정, 지리 좌표값이 내장된 전자기후지도에 적지 판별 기준 범위별로 가중치를 부여하여 중첩 분석하였다. 생육 기간은 6~8월로 설정하였고, 재배 적성 평가 기온은 3개월 동안의 평균 기온을 기준으로 하여 재배 적지(21°C 미만), 재배 가능지(21~23°C), 재배 부적지(23°C 이상)로 평가하였다. 배추 결구 적온 기준은 6월 평균 기온 15~17°C로 평가하였다. 이를 바탕으로 미래 재배지 변동 예측도를 작성하고 면적 변동을 분석하였다. 이 결과는 기후변화에 대응한 재배지 이동, 재배관리 등 영농의사결정 수단과 수급정책 수립 등에 활용될 수 있다.
Development of the Hybrid Conjugated Polymer Solar Cell Based on GaN Quantum Dots
Kim, Minji,Shin, Min Jeong,Gwon, Dongoh,Ahn, Hyung Soo,Yi, Sam Nyung,Kim, Pan Seok,Yoon, Sung Cheol,Lee, Changjin,Park, Jungsik,Shin, Keesam,Ha, Dong Han,Sawaki, Nobuhiko IOP Publishing 2013 Japanese journal of applied physics Vol.52 No.1